Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Detecting alcoholism. The CAGE questionnaire

1984 • 4,045 citations

Assay of proteins in the presence of interfering materials

1976 • 3,217 citations

Separation of leukocytes from blood and bone marrow

1968 • 2,787 citations

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

1968 • 2,659 citations

The CAGE Questionnaire: Validation of a New Alcoholism Screening Instrument

1974 • 2,274 citations

Role of CYP2E1 in the Hepatotoxicity of Acetaminophen

1996 • 641 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1989 • 527 citations

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

1989 • 488 citations

Biochemical and Molecular Basis of Alcohol-Induced Injury to Liver and Other Tissues

1988 • 452 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

1989 • 320 citations

Hepatic, Metabolic and Toxic Effects of Ethanol: 1991 Update

1991 • 282 citations

Bioactivation of Halogenated Hydrocarbons by Cytochrome P4502E1

1993 • 270 citations

Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates

1993 • 244 citations

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride— and iron-dependent microsomal lipid peroxidation

1992 • 212 citations

Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity

1994 • 207 citations

Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P450IIE1

1990 • 199 citations

Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

1986 • 173 citations

Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics

1994 • 167 citations

HumanP₁-450gene sequence and correlation of mRNA with genetic differences in benzo(a]pyrene metabolism

1985 • 141 citations

Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P450 2E1

1993 • 125 citations

Cytochrome P450IIE1 Is Elevated in Lymphocytes from Poorly Controlled Insulin-Dependent Diabetics^*

1990 • 116 citations

Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1

1995 • 111 citations

Ethanol and Isopentanol Increase CYP3A and CYP2E in Primary Cultures of Human Hepatocytes

1995 • 104 citations

Expression, induction, and catalytic activity of the ethanol-inducible cytochrome P450 (CYP2E1) in human fetal liver and hepatocytes.

1996 • 95 citations

[56] Isolation of P450 enzymes from human liver

1991 • 90 citations

Immunochemical identification of cytochrome P-450 isozyme 3a (P-450ALC) in rabbit nasal and kidney microsomes and evidence for differential induction by alcohol.

1986 • 81 citations

Decrease in Cytochrome P4502E1 as Assessed by the Rate of Chlorzoxazone Hydroxylation in Alcoholics during the Withdrawal Phase

1995 • 80 citations

Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone

1997 • 67 citations

Characterization of Cytochrome P4502E1 Turnover in Transfected HepG2 Cells Expressing Human CYP2E1

1997 • 66 citations

High-performance liquid chromatographic determination of chlorzoxazone and 6-hydroxychlorzoxazone in serum: a tool for indirect evaluation of cytochrome P4502E1 activity in humans

1993 • 64 citations

The isolation and purification of human peripheral blood monocytes in cell suspension

1980 • 63 citations

Identification and induction of cytochromes P450, P450IIE1 and P450IA1 in rabbit bone marrow.

1989 • 54 citations

Selective expression of CYP3A5 and not CYP3A4 in human blood

1996 • 50 citations

Induction of cytochrome P-450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone.

1990 • 36 citations

Immunological Detection of CYP2E1 in Fresh Rat Lymphocytes and Its Pretranslational Induction by Fasting

1996 • 34 citations

Chlorzoxazone as a Single Sample Probe of Hepatic CYP2E1 Activity in Humans

1996 • 29 citations

Use of Lymphocytes for Assessing Ethanol‐Mediated Alterations in the Expression of Hepatic Cytochrome P4502E1

1995 • 27 citations

Urinary excretion of 6-hydroxychlorzoxazone as an index of CYP2E1 activity*

1995 • 26 citations