Characterization of Cytochrome P4502E1 Turnover in Transfected HepG2 Cells Expressing Human CYP2E1

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1991 • 1,173 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

1987 • 542 citations

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1989 • 527 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

Cytochrome P450IIe1: Roles in Nitrosamine Metabolism and Mechanisms of Regulation

1990 • 361 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction.

1984 • 324 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

1989 • 277 citations

Ethanol Induces CYP2E1 by Protein Stabilization

1995 • 264 citations

Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates

1993 • 244 citations

Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P450IIE1

1990 • 199 citations

Stabilization of Cytochrome P450j Messenger Ribonucleic Acid in the Diabetic Rat

1987 • 199 citations

Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1

1993 • 198 citations

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

1988 • 170 citations

Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells.

1995 • 165 citations

Degradation of cytochrome P450 2E1: Selective loss after labilization of the enzyme

1992 • 151 citations

Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control.

1993 • 122 citations

Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes.

1992 • 119 citations

Substrate-, hormone-, and cAMP-regulated cytochrome P450 degradation.

1990 • 112 citations

Ethanol Oxidation and Toxicity: Role of Alcohol P‐450 Oxygenase

1986 • 90 citations

Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation

1990 • 84 citations

Acetone‐regulated synthesis and degradation of cytochrome P4502E2 and cytochrome P4502B1 in rat liver

1991 • 79 citations

[24] Multicatalytic endopeptidase complex: Proteasome

1994 • 79 citations

Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells

1992 • 73 citations

Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.

1995 • 60 citations

Organization and differential expression of two highly similar genes in the rabbit alcohol-inducible cytochrome P-450 subfamily.

1988 • 59 citations

Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes

1991 • 59 citations

Purification and properties of a shortened form of cytochrome P-450 2E1: deletion of the NH2-terminal membrane-insertion signal peptide does not alter the catalytic activities.

1991 • 56 citations

[11] Expression of mammalian P450s in Escherichia coli

1991 • 47 citations

Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450.

1990 • 47 citations

Purification and Characterization of Two Membrane-Bound Serine Proteinases from Rat Liver Microsomes Active in Degradation of Cytochrome P450

1993 • 40 citations

Evidence against a role for serine 129 in determining murine cytochrome P450 Cyp2e-1 protein levels

1994 • 29 citations

Rabbit P450 2E1 Expressed in CHO-K1 Cells Has a Short Half-Life

1995 • 25 citations

Role of the Proteasome Complex in Degradation of Human CYP2E1 in Transfected HepG2 Cells

1996 • 24 citations