Mammalian cells share a common pathway for the relief of DNA replication arrest by O6-alkyl guanine, incorporated 6-thioguanine and UV photoproducts

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.

1984 • 437 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography

1980 • 301 citations

Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations

1981 • 289 citations

DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

1979 • 247 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards

1986 • 233 citations

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

1984 • 223 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

Mutagenesis in Saccharomyces Cerevisiae

1982 • 181 citations

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards

1987 • 178 citations

Human tumor cell strains defective in the repair of alkylation damage

1980 • 169 citations

Sequence specificity of guanine alkylation and repair

1988 • 100 citations

BASIC BIOCHEMICAL EFFECTS AND MECHANISM OF ACTION OF 6-THIOGUANINE.

1963 • 88 citations

Mechanisms of chemical mutagenesis and carcinogenesis: effects on DNA replication of methylation at the O⁶-guanine position of dGTP

1983 • 86 citations

The Role of O6-Methylguanine in Human Cell Killing, Sister Chromatid Exchange Induction and Mutagenesis: A Review

1987 • 78 citations

6-Thioguanine-induced DNA damage as a determinant of cytotoxicity in cultured Chinese hamster ovary cells.

1984 • 74 citations

Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine

1986 • 67 citations

Unilateral chromatid damage: a new basis for 6-thioguanine cytotoxicity.

1983 • 60 citations

Properties of mammalian O6-alkylguanine-DNA transferases

1990 • 50 citations

Transfection of murine multi-potent haemopoietic stem cells with an E.coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents

1988 • 47 citations

DNA sequence has an effect on the extent and kinds of alkylation of DNA by a potent carcinogen

1985 • 39 citations

Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells

1989 • 35 citations

The effects of inhibitors of DNA biosynthesis on the cytotoxicity of 6-thioguanine.

1981 • 34 citations

DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells

1987 • 34 citations

Role of the uvrE gene product and of inducible O-methylguanine removal in the induction of mutations by N-methyl-N′-nitro-N-nitrosoguanidine in Escherichia coli

1980 • 34 citations

Defective Post-replication Recovery and u.v. Sensitivity in a Simian Virus 40-transformed Indian Muntjac Cell Line

1986 • 32 citations

Chinese hamster cells harbouring the Escherichia coli O⁶-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents

1986 • 30 citations

The effects of beta-2'-deoxythioguanosine on survival and progression in mammalian cells.

1971 • 29 citations

Properties of N-methyl-N-nitrosourea-resistant, Mex- derivatives of an SV40-immortalized human fibroblast cell line

1989 • 28 citations

Preferential alkylation by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) of guanines with guanines as neighboring bases in DNA

1988 • 25 citations

N-Methyl-N′-nitro-N-nitrosoguanidine-resistant HeLa S3 cells still have little O⁶-methylguanine-DNA methyltransferase activity and are hypermutable by alkylating agents

1987 • 23 citations

DNA sequence specificity of guanine N⁷-alkylations for a series of structurally related triazenes

1988 • 23 citations

Termination of DNA synthesis in vitro at apurinic sites but not at ethyl adducts on the template

1982 • 20 citations

Characterization of a CHO variant in respect to alkylating agent-induced biological effects and DNA repair

1987 • 19 citations

A comparison of cell survival, mutation and persistence of putative promutagenic lesions in Chinese hamster cells exposed to BNU or MNU

1986 • 14 citations

Molecular mechanisms of alkylation sensitivity in Indian muntjac cell lines

1989 • 12 citations

Excessive chromosome fragility and abundance of sister-chromatid exchanges induced by UV in an Indian muntjac cell line defective in postreplication (daughter strand) repair

1986 • 11 citations

Differences in induction of sister chromatid exchanges in MNNG-resistant Hela S3 Mer⁻cell lines

1990 • 10 citations

Properties of mer− HeLa cells sensitive or resistant to the cytotoxic effects of MNU; effects on DNA synthesis and of post treatment with caffeine

1990 • 9 citations

Molecular cloning of a mammalian gene involved in the fixation of UV-induced mutations

1990 • 2 citations