Interleukin-17 Orchestrates the Granulocyte Influx into Airways after Allergen Inhalation in a Mouse Model of Allergic Asthma

Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense

2001 • 1,505 citations

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

1996 • 1,496 citations

Human IL-17: a novel cytokine derived from T cells.

1995 • 1,014 citations

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

1995 • 991 citations

IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

1998 • 954 citations

IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines

2001 • 928 citations

Neutrophil Recruitment by Human IL-17 Via C-X-C Chemokine Release in the Airways

1999 • 881 citations

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

1998 • 810 citations

CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene.

1993 • 751 citations

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1999 • 723 citations

Microbial Lipopeptides Induce the Production of IL-17 in Th Cells

2000 • 589 citations

High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism

2000 • 588 citations

Sudden-Onset Fatal Asthma: A Distinct Entity with Few Eosinophils and Relatively More Neutrophils in the Airway Submucosa?

1993 • 588 citations

QUANTIFICATION OF MURINE CYTOKINE mRNAs USING REAL TIME QUANTITATIVE REVERSE TRANSCRIPTASE PCR

1999 • 567 citations

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes

1998 • 565 citations

Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines

1998 • 451 citations

Increased Neutrophil Numbers and IL-8 Levels in Airway Secretions in Acute Severe Asthma

2000 • 422 citations

IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells

1999 • 415 citations

IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha.

1999 • 361 citations

Requirement of Tumor Necrosis Factor Receptor–Associated Factor (Traf)6 in Interleukin 17 Signal Transduction

2000 • 342 citations

IL-17 Stimulates Granulopoiesis in Mice: Use of an Alternate, Novel Gene Therapy-Derived Method for In Vivo Evaluation of Cytokines

1998 • 320 citations

Tumour necrosis factor‐α: The role of this multifunctional cytokine in asthma

2001 • 314 citations

The regulation of AP-1 activity by mitogen-activated protein kinases

1996 • 312 citations

IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GROα Chemokine from Mesothelial Cells

2000 • 304 citations

Bronchial Neutrophilia in Patients with Noninfectious Status Asthmaticus

1998 • 302 citations

Evidence for a Role of IL-17 in Organ Allograft Rejection: IL-17 Promotes the Functional Differentiation of Dendritic Cell Progenitors

1999 • 297 citations

Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice.

1999 • 291 citations

Interleukin-17 is Produced by Both Th1 and Th2 Lymphocytes, and Modulates Interferon-γ- and Interleukin-4-Induced Activation of Human Keratinocytes

2000 • 289 citations

NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells.

1999 • 288 citations

NF-κB-Inducing Kinase Is a Common Mediator of IL-17-, TNF-α-, and IL-1β-Induced Chemokine Promoter Activation in Intestinal Epithelial Cells

1999 • 252 citations

ROLE OF PLASMA EXUDATION IN ASTHMATIC AIRWAYS

1986 • 227 citations

Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways.

1994 • 227 citations

Airway structure and inflammatory cells in fatal attacks of asthma

1996 • 214 citations

Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia.

1998 • 142 citations

Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo

2000 • 139 citations

Mouse IL-17: A Cytokine Preferentially Expressed by αβTCR+CD4—CD8— T Cells

1996 • 138 citations

Rapid Increase in Bone-marrow Eosinophil Production and Responses to Eosinopoietic Interleukins Triggered by Intranasal Allergen Challenge

1997 • 135 citations

Identification of mouse granulocyte chemotactic protein-2 from fibroblasts and epithelial cells. Functional comparison with natural KC and macrophage inflammatory protein-2.

1996 • 110 citations

Role of Neutrophil Elastase in Hypersecretion During COPD Exacerbations, and Proposed Therapies

2000 • 108 citations

Peripheral blood and airway tissue expression of transforming growth factor β by neutrophils in asthmatic subjects and normal control subjects

2000 • 105 citations

Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17

1998 • 103 citations

The Effect of Endotoxin Inhalation on Airway Responsiveness and Cellular Influx in Rats

1990 • 96 citations

CD4+ T Cells Regulate Surgical and Postinfectious Adhesion Formation

2002 • 94 citations

Blockade of CTLA-4 enhances allergic sensitization and eosinophilic airway inflammation in genetically predisposed mice

2002 • 86 citations

Eosinophilic rhinitis accompanies the development of lower airway inflammation and hyper‐reactivity in sensitized mice exposed to aerosolized allergen

2001 • 78 citations

Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro

1999 • 69 citations

Mechanisms of Airway Goblet Cell Mucin Release: Studies with Cultured Tracheal Surface Epithelial Cells

1989 • 58 citations

NH2- and COOH-Terminal Truncations of Murine Granulocyte Chemotactic Protein-2 Augment the In Vitro and In Vivo Neutrophil Chemotactic Potency

1999 • 56 citations

A mouse model of lung injury induced by microbial products: implication of tumor necrosis factor.

1994 • 52 citations

Enhancement of Acute Phase and Inhibition of Chronic Phase of Experimental Autoimmune Neuritis in Lewis Rats by Intranasal Administration of Recombinant Mouse Interleukin 17: Potential Immunoregulatory Role

2000 • 41 citations

Purification and identification of human and mouse granulocyte chemotactic protein-2 isoforms

1997 • 21 citations

Effects of depletion of cells bearing the interleukin-2 receptor on immunoglobulin production and allergic airway responses in the rat.

1996 • 18 citations

Interleukin-17 is released by nickel-specific T cells and regulates ICAM-1 expression and chemokine production in human keratinocytes

1998 • 9 citations

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