A mouse model of lung injury induced by microbial products: implication of tumor necrosis factor.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

1989 • 709 citations

Clinical predictors of the adult respiratory distress syndrome

1982 • 684 citations

STRUCTURAL ALTERATIONS OF LUNG PARENCHYMA IN THE ADULT RESPIRATORY DISTRESS SYNDROME

1982 • 584 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

The Risk Factors, Incidence, and Prognosis of ARDS following Septicemia

1983 • 254 citations

Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation.

1991 • 244 citations

Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model

1993 • 208 citations

Respiratory failure after endotoxin infusion in sheep: lung mechanics and lung fluid balance

1982 • 197 citations

Cachetin/TNF-α in Septic Shock and Septic Adult Respiratory Distress Syndrome

1988 • 183 citations

The role of cytokine mediators in septic shock.

1990 • 172 citations

Elevated lnterleukin-1 Release by Human Alveolar Macrophages during the Adult Respiratory Distress Syndrome

1989 • 162 citations

Granulocyte Depletion Prevents Tumor Necrosis Factor-mediated Acute Lung Injury in Guinea Pigs

1988 • 141 citations

Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury

1989 • 139 citations

Tumor necrosis factor-independent IL-6 production during murine listeriosis.

1991 • 117 citations

Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

1993 • 114 citations

Production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) in patients with AIDS. Enhanced level of TNF-alpha is related to a higher cytotoxic activity.

1989 • 112 citations

Occurrence of the adult respiratory distress syndrome in neutropenic patients.

1986 • 94 citations

Limited involvement of interleukin‐6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin‐6 or its receptor in various murine models

1992 • 83 citations

Studies on the Role of Tumor Necrosis Factor in Adult Respiratory Distress Syndrome

1992 • 82 citations

Role of tumour necrosis factor and reactive oxygen intermediates in lipopolysaccharide-induced pulmonary oedema and lethality

1993 • 75 citations

Endotoxin-mediated pulmonary endothelial cell injury.

1986 • 75 citations

Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms.

1990 • 61 citations

Adult respiratory distress syndrome—a review

1983 • 61 citations

Interleukin-6 in mouse hypersensitivity pneumonitis: changes in lung free cells following depletion of endogenous IL-6 or direct administration of IL-6

1992 • 61 citations

Neutrophil depletion does not prevent lung edema after endotoxin infusion in goats

1987 • 58 citations

Characteristics of alveolar macrophages in experimental septic lung

1992 • 38 citations

Tumor Necrosis Factor-Induced Downregulation of Its Receptors in HeLa Cells

1987 • 38 citations

Pulmonary effects of continuous endotoxin infusion in the rat.

1991 • 37 citations

Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury

1991 • 33 citations

Enzyme activities of lung lavage in silicosis

1990 • 27 citations

Effects of ibuprofen on a pig Pseudomonas ARDS model

1986 • 26 citations

Potential Treatment of Sepsis Syndrome with Cytokine-Specific Agents

1992 • 25 citations

Prostacyclin in experimental septic acute respiratory failure

1983 • 22 citations