Tacrolimus and pimecrolimus: From clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

A Short-Term Trial of Tacrolimus Ointment for Atopic Dermatitis

1997 • 529 citations

Pyoderma gangrenosum: Classification and management

1996 • 528 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

1999 • 521 citations

Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents

2002 • 362 citations

Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand

1990 • 353 citations

Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children

2001 • 336 citations

A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric patients

2001 • 320 citations

Molecular cloning and overexpression of the human FK506-binding protein FKBP

1990 • 316 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: Part I, efficacy

2001 • 284 citations

Tacrolimus Ointment does not Affect Collagen Synthesis: Results of a Single-Center Randomized Trial

1998 • 275 citations

Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.

1993 • 274 citations

SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis

2001 • 243 citations

Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: Part II, safety

2001 • 237 citations

The new topical ascomycin derivative SDZ ASM 981 does not induce skin atrophy when applied to normal skin for 4 weeks: a randomized, double-blind controlled study

2001 • 219 citations

Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome.

2001 • 207 citations

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast

1992 • 195 citations

A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology

1997 • 183 citations

Erosive mucosal lichen planus: response to topical treatment with tacrolimus

1999 • 179 citations

Topical Tacrolimus Is Not Effective in Chronic Plaque Psoriasis

1998 • 170 citations

Tacrolimus (FK 506)—A New Therapeutic Agent for Severe Recalcitrant Psoriasis

1992 • 161 citations

The impact of tacrolimus ointment on health-related quality of life of adult and pediatric patients with atopic dermatitis

2001 • 151 citations

Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin.

1990 • 145 citations

Human epidermal Langerhans' cells are targets for the immunosuppressive macrolide tacrolimus (FK506)

2001 • 144 citations

Tacrolimus ointment for the treatment of steroid-induced rosacea: A preliminary report

2001 • 140 citations

Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription.

1991 • 123 citations

Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids)

2001 • 119 citations

The novel ascomycin derivative SDZ ASM 981 is effective for psoriasis when used topically under occlusion

1998 • 114 citations

Parastomal pyoderma gangrenosum: Clinical features and management

2000 • 109 citations

Systemic Tacrolimus (FK 506) Is Effective for the Treatment of Psoriasis in a Double-blind, Placebo-Controlled Study

1996 • 101 citations

Tacrolimus Ointment in the Treatment of Chronic Cutaneous Graft-vs-Host Disease

2001 • 100 citations

Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia.

1997 • 87 citations

Topical FK506 Suppresses Cytokine and Costimulatory Molecule Expression in Epidermal and Local Draining Lymph Node Cells During Primary Skin Immune Responses

1998 • 85 citations

Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis

2001 • 75 citations

Efficacy of FK 506 in the treatment of recalcitrant pyoderma gangrenosum.

1991 • 68 citations

Systemic tacrolimus (FK506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study

1995 • 62 citations

Absorption of Topical Tacrolimus (FK506) in vitro through Human Skin: Comparison with Cyclosporin A

1997 • 58 citations

FK506 in the treatment of inflammatory skin disease: promises and perspectives

1996 • 57 citations

Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants

1994 • 55 citations

A case of ichthyosis linearis circumflexa successfully treated with topical tacrolimus

2000 • 46 citations

Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans

1999 • 35 citations

Efficacy of tacrolimus (FK 506) in idiopathic treatment-resistant pyoderma gangrenosum

1998 • 21 citations