Human epidermal Langerhans' cells are targets for the immunosuppressive macrolide tacrolimus (FK506)

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

1989 • 1,043 citations

A Short-Term Trial of Tacrolimus Ointment for Atopic Dermatitis

1997 • 529 citations

Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).

1992 • 490 citations

Immunomorphological and Ultrastructural Characterization of Langerhans Cells and a Novel, Inflammatory Dendritic Epidermal Cell (IDEC) Population in Lesional Skin of Atopic Eczema

1996 • 404 citations

Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI.

1992 • 388 citations

The skin immune system: progress in cutaneous biology

1993 • 387 citations

Peptidylproline cis‐trans‐isomerases: immunophilins

1993 • 349 citations

South Africa

1985 • 333 citations

A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children☆☆☆★★★♢

1998 • 312 citations

Induction of Fc epsilon R2/CD23 on human epidermal Langerhans cells by human recombinant interleukin 4 and gamma interferon.

1989 • 209 citations

Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction.

1988 • 160 citations

Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus

1991 • 159 citations

Anti-Inflammatory Effect of FK-506 on Human Skin Mast Cells

1992 • 146 citations

Immunosuppressive Macrolides of the Type FK 506: A Novel Class of Topical Agents for Treatment of Skin Diseases?

1992 • 140 citations

Increased expression of epidermal IL-8 receptor in psoriasis. Down-regulation by FK-506 in vitro.

1993 • 123 citations

Comparative analysis of B7‐1 and B7‐2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines

1995 • 111 citations

FK 506: historical perspectives.

1991 • 111 citations

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp)

1996 • 104 citations

Systemic Tacrolimus (FK 506) Is Effective for the Treatment of Psoriasis in a Double-blind, Placebo-Controlled Study

1996 • 101 citations

FcεRI-expressing antigen-presenting cells: new players in the atopic game

1997 • 89 citations

Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.

1987 • 89 citations

The effect of cyclosporine on epidermal cells. I. Cyclosporine inhibits accessory cell functions of epidermal Langerhans cells in vitro.

1988 • 87 citations

Topical FK506 Suppresses Cytokine and Costimulatory Molecule Expression in Epidermal and Local Draining Lymph Node Cells During Primary Skin Immune Responses

1998 • 85 citations

Characterization of the anti-inflammatory effect of FK-506 on human mast cells.

1991 • 78 citations

Effect of FK-506 on human mixed lymphocyte reaction in vitro.

1987 • 72 citations

Cyclosporin A Inhibits the Antigen-Presenting Functions of Freshly Isolated Human Langerhans Cells In Vitro

1991 • 69 citations

Systemic tacrolimus (FK506) is effective for the treatment of psoriasis in a double-blind, placebo-controlled study

1995 • 62 citations

Regulation of lnterleukin-5 Production by Peripheral Blood Mononuclear Cells from Atopic Patients with FK506, Cyclosporin A and Glucocorticoid

1994 • 61 citations

FK506 in the treatment of inflammatory skin disease: promises and perspectives

1996 • 57 citations

EFFECTS OF COMBINATION TREATMENT WITH FK506 AND CYCLOSPORINE ON SURVIVAL TIME AND VASCULAR CHANGES IN RENAL-ALLOGRAFT-RECIPIENT DOGS

1989 • 57 citations

Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells

1997 • 55 citations

Topical FK506: suppression of allergic and irritant contact dermatitis in the guinea pig

1994 • 53 citations

Direct Effects of Glucocorticosteroids on Epidermal Langerhans Cells

1989 • 53 citations

Topical FK506 – Clinical Potential or Laboratory Curiosity?

1994 • 46 citations

Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs

1997 • 42 citations

Immunosuppressive effect of FK506 on experimental allergic encephalomyelitis in rats

1988 • 36 citations

FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0G1 phases of the cell cycle

1996 • 33 citations

An assay for the detection of interleukin-1 synthesis inhibitors: effects of antirheumatic drugs.

1989 • 29 citations

Studies on FK506 in experimental organ transplantation.

1988 • 22 citations

Combination of cyclosporine A and topical corticosteroid in the treatment of psoriasis.

1988 • 19 citations

The Inducible Transcription Factor NF-AT Plays an Important Role in the Activation of the Murine lnterleukin-4 Promoter

1995 • 15 citations

Effects of Chloroquine on Antigen-Presenting Functions of Epidermal Cells from Normal and Psoriatic Skin

1992 • 11 citations