The single-stranded DNA end binding site of p53 coincides with the C- terminal regulatory region

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1993 • 239 citations

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.

1992 • 230 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Mutations in p53 as potential molecular markers for human breast cancer.

1991 • 222 citations

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1993 • 206 citations

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 • 203 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

1995 • 160 citations

p53 oligomerization and DNA looping are linked with transcriptional activation.

1994 • 127 citations

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

1984 • 126 citations

p53: A Cell Cycle Regulator Activated by DNA Damage

1995 • 121 citations

A DNA binding domain is contained in the C-terminus ofwild typep53 protein

1991 • 113 citations

Identification of a Minimal Transforming Domain of p53: Negative Dominance through Abrogation of Sequence-Specific DNA Binding

1992 • 113 citations

Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.

1994 • 60 citations

[Leu5]enkephalin-encoding sequences are targets for a specific DNA-binding factor.

1995 • 17 citations