The Laminin α2-Chain Short Arm Mediates Cell Adhesion through Both the α1β1 and α2β1 Integrins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin

1993 • 1,352 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Supramolecular assembly of basement membranes

1996 • 693 citations

Laminin receptor on platelets is the integrin VLA-6

1988 • 679 citations

Macromolecular organization of basement membranes

1996 • 661 citations

Mutations in the laminin α2–chain gene (LAMA2) cause merosin–deficient congenital muscular dystrophy

1995 • 615 citations

Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.

1990 • 398 citations

The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin.

1990 • 375 citations

Merosin, a protein specific for basement membranes of Schwann cells, striated muscle, and trophoblast, is expressed late in nerve and muscle development.

1988 • 371 citations

Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.

1989 • 363 citations

Murine muscular dystrophy caused by a mutation in the laminin α2 (Lama2) gene

1994 • 346 citations

Protease Resistance and Conformation of Laminin

1982 • 313 citations

The integrin alpha 6 beta 4 is a laminin receptor.

1992 • 299 citations

Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus.

1994 • 299 citations

Laminin-binding protein 120 from brain is closely related to the dystrophin-associated glycoprotein, dystroglycan, and binds with high affinity to the major heparin binding domain of laminin

1993 • 282 citations

Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton

1996 • 264 citations

Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity.

1985 • 264 citations

Deletion of Integrin α1 by Homologous Recombination Permits Normal Murine Development but Gives Rise to a Specific Deficit in Cell Adhesion

1996 • 263 citations

Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues

1994 • 262 citations

Defective muscle basement membrane and lack of M-laminin in the dystrophic dy/dy mouse.

1994 • 254 citations

Comparative analysis of structurally defined heparin binding sequences reveals a distinct spatial distribution of basic residues.

1993 • 242 citations

Self-assembly and calcium-binding sites in laminin. A three-arm interaction model

1993 • 239 citations

Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.

1995 • 235 citations

Laminin receptors: achieving specificity through cooperation

1995 • 225 citations

Distinct and overlapping ligand specificities of the alpha 3A beta 1 and alpha 6A beta 1 integrins: recognition of laminin isoforms.

1994 • 204 citations

Relationship between neuronal migration and cell-substratum adhesion: laminin and merosin promote olfactory neuronal migration but are anti-adhesive.

1991 • 204 citations

A neuronal cell line (PC12) expresses two β1-class integrins—α1β1, and α3β1—that recognize different neurite outgrowth-promoting domains in laminin

1990 • 174 citations

Subunit structure of a laminin-binding integrin and localization of its binding site on laminin

1989 • 172 citations

Expression of laminin isoforms in mouse myogenic cells in vitro and in vivo

1995 • 172 citations

Distribution of laminin and collagens during avian neural crest development

1987 • 171 citations

Identification of a novel mutant transcript of laminin α2 chain gene responsible for muscular dystrophy and dysmyelination in dy^2J mice

1995 • 170 citations

A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins.

1995 • 164 citations

Antibody to integrin α6 subunit specifically inhibits cell-binding to laminin fragment 8

1990 • 161 citations

Domains of laminin

1996 • 158 citations

Expression of beta 1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms

1993 • 155 citations

Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes.

1991 • 135 citations

Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor

1996 • 124 citations

Expression of α1 integrin, a laminin-collagen receptor, during myogenesis and neurogenesis in the avian embryo

1992 • 124 citations

Mild Congenital Muscular Dystrophy in Two Patients with an Internally Deleted Laminin 2-Chain

1997 • 122 citations

Expression and function of the cytoplasmic variants of the integrin alpha 6 subunit in transfected K562 cells. Activation-dependent adhesion and interaction with isoforms of laminin.

1993 • 117 citations

Laminin Variants and Integrin Laminin Receptors in Developing and Adult Human Smooth Muscle

1993 • 115 citations

Mapping of Network-forming, Heparin-binding, and α1β1 Integrin-recognition Sites within the α-Chain Short Arm of Laminin-1

1995 • 115 citations

Epithelial integrins

1996 • 113 citations

Cell and heparin binding in the distal long arm of laminin: identification of active and cryptic sites with recombinant and hybrid glycoprotein [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 1):1623]

1993 • 110 citations

Protein binding and cell adhesion properties of two laminin isoforms (amb1eb2e, amb1sb2e) from human placenta

1994 • 94 citations

Binding of Purified Collagen Receptors (α1β1, α2β1) and RGD‐Dependent Integrins to Laminins and Laminin Fragments

1994 • 94 citations

Genetically determined defect of Schwann cell basement membrane in dystrophic mouse

1975 • 92 citations

Merosin promotes cell attachment and neurite outgrowth and ls a component of the neurite-promoting factor of RN22 schwannoma cells

1992 • 90 citations

Laminin-binding integrin α7β1 : functional characterization and expression in normal and malignant melanocytes

1991 • 86 citations

Substitution of a conserved cysteine-996 in a cysteine-rich motif of the laminin alpha2-chain in congenital muscular dystrophy with partial deficiency of the protein.

1996 • 80 citations

Recombinant laminin G domain mediates myoblast adhesion and heparin binding.

1993 • 80 citations

Multiple cell surface receptors for the short arms of laminin: alpha 1 beta 1 integrin and RGD-dependent proteins mediate cell attachment only to domains III in murine tumor laminin.

1991 • 76 citations

Alpha 1 beta 1 integrin on neural crest cells recognizes some laminin substrata in a Ca(2+)-independent manner.

1992 • 59 citations

Neural Crest Cell Interactions with Laminin: Structural Requirements and Localization of the Binding Site for α1β1 Integrin

1994 • 59 citations

Ionophore A23187 raises cyclic AMP levels in macrophages by stimulating prostaglandin E formation

1979 • 51 citations

Differential expression of integrin α subunits supports distinct roles during lung branching morphogenesis

1996 • 47 citations

Plasticity of integrin expression by nerve-derived connective tissue cells. Human Schwann cells, perineurial cells, and fibroblasts express markedly different patterns of beta 1 integrins during nerve development, neoplasia, and in vitro.

1991 • 33 citations

Ongoing block of Schwann cell differentiation and deployment in dystrophic mouse spinal roots

1981 • 20 citations

A quantitative immunohistochemical study of the expression of integrins by nerves in psoriatic and normal skin

1992 • 14 citations

Differential expression of beta 1, beta 3, and beta 4 integrin subunits in nonneoplastic neural cells of the peripheral and autonomic nervous system and in tumors derived from these cells.

1994 • 12 citations