Regulation of podocyte structure during the development of nephrotic syndrome

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

Organogenesis of the kidney

1987 • 904 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis

1996 • 708 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans (heparan sulfate) by enzyme digestion.

1980 • 650 citations

Modulation of Cellular Thermoresistance and Actin Filament Stability Accompanies Phosphorylation-Induced Changes in the Oligomeric Structure of Heat Shock Protein 27

1995 • 631 citations

POROUS SUBSTRUCTURE OF THE GLOMERULAR SLIT DIAPHRAGM IN THE RAT AND MOUSE

1974 • 555 citations

Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review

1993 • 551 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

Identification and characterization of podocalyxin--the major sialoprotein of the renal glomerular epithelial cell.

1984 • 506 citations

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

1993 • 494 citations

Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity.

1994 • 493 citations

A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein.

1991 • 445 citations

A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS

1965 • 421 citations

Permselectivity of the glomerular capillary wall: III. Restricted transport of polyanions

1975 • 383 citations

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995 • 344 citations

Structure and function of podocytes: an update

1995 • 329 citations

The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium.

1990 • 325 citations

Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat.

1989 • 305 citations

Permselectivity of the Glomerular Capillary Wall

1978 • 301 citations

Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidneys.

1984 • 299 citations

An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis

1975 • 296 citations

AN ELECTRON MICROSCOPE STUDY OF THE GLOMERULUS IN NEPHROSIS, GLOMERULONEPHRITIS, AND LUPUS ERYTHEMATOSUS

1957 • 289 citations

Glomerular polyanion. Alteration in aminonucleoside nephrosis.

1970 • 285 citations

A glomerular permeability factor produced by human T cell hybridomas

1991 • 269 citations

Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain.

1993 • 267 citations

Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man.

1988 • 267 citations

The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron.

1990 • 261 citations

Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis

1992 • 247 citations

Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody.

1988 • 241 citations

Glomerular filtration of proteins: Clearance of anionic, neutral, and cationic horseradish peroxidase in the rat

1978 • 239 citations

Pathogenesis of polycation-induced alterations ("fusion") of glomerular epithelium.

1977 • 237 citations

Glomerular Epithelium: Structural Alterations Induced by Polycations

1975 • 230 citations

Alterations of the glomerular epithelium in acute aminonucleoside nephrosis. Evidence for formation of occluding junctions and epithelial cell detachment.

1976 • 228 citations

Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein.

1991 • 227 citations

Differentiation of epithelial foot processes and filtration slits: sequential appearance of occluding junctions, epithelial polyanion, and slit membranes in developing glomeruli.

1978 • 223 citations

14 Expression and Function of the Low-molecular-weight Heat Shock Proteins

1994 • 223 citations

Cell renewal of glomerular cell types in normal rats. An autoradiographic analysis

1983 • 223 citations

Loss of anionic sites from the glomerular basement membrane in aminonucleoside nephrosis.

1978 • 199 citations

Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis

1995 • 192 citations

Loss of heparan sulfate proteoglycan from glomerular basement membrane of nephrotic rats.

1983 • 174 citations

Assembly of the glomerular filtration surface. Differentiation of anionic sites in glomerular capillaries of newborn rat kidney.

1980 • 167 citations

AMINONUCLEOSIDE NEPHROSIS

1959 • 164 citations

GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit.

1994 • 159 citations

The role of podocytes in the development of glomerular sclerosis.

1994 • 155 citations

Expression and function of the low-molecular-weight heat shock proteins

1994 • 152 citations

Structure-stabilizing forces in the glomerular tuft.

1995 • 150 citations

Structural determinants of glomerular hydraulic permeability

1994 • 146 citations

Podocytes in glomerulus of rat kidney express a characteristic 44 KD protein.

1991 • 144 citations

Renal enlargement: Comparative autoradiographic studies of 3H-thymidine uptake in diabetic and uninephrectomized rats

1983 • 142 citations

Differentiation of cell types in the mammalian kidney by immunofluorescence microscopy using antibodies to intermediate filament proteins and desmoplakins

1983 • 141 citations

The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1.

1992 • 141 citations

Reduced sialylation of podocalyxin--the major sialoprotein of the rat kidney glomerulus--in aminonucleoside nephrosis.

1985 • 140 citations

Progressive renal failure—inability of podocytes to replicate and the consequences for development of glomerulosclerosis

1996 • 136 citations

Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis.

1996 • 134 citations

Analysis of the resistance to heat and hydrogen peroxide stresses in COS cells transiently expressing wild type or deletion mutants of the Drosophila 27‐kDa heat‐shock protein

1993 • 129 citations

Acute reversible proteinuria induced by infusion of the polycation hexadimethrine

1981 • 127 citations

Transient ischemia or heat stress induces a cytoprotectant protein in rat kidney

1991 • 127 citations

Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases

1994 • 124 citations

Glomerular Sialoprotein

1969 • 123 citations

Biogenesis of podocalyxin--the major glomerular sialoglycoprotein--in the newborn rat kidney.

1989 • 122 citations

Characterization of glomerular epithelial cell matrix receptors.

1992 • 120 citations

Characterization of an inhibitor of actin polymerization in vinculin‐rich fraction of turkey gizzard smooth muscle

1988 • 117 citations

Podocyte alpha-actinin induction precedes foot process effacement in experimental nephrotic syndrome

1997 • 117 citations

Polycation-induced dislocation of slit diaphragms and formation of cell junctions in rat kidney glomeruli: the effects of low temperature, divalent cations, colchicine, and cytochalasin B.

1978 • 116 citations

Glomerulogenesis in the developing kidney.

1991 • 115 citations

Diversity among tight junctions in rat kidney: glomerular slit diaphragms and endothelial junctions express only one isoform of the tight junction protein ZO-1.

1992 • 113 citations

Altered glomerular permeability as a result of focal detachment of the visceral epithelium

1982 • 110 citations

Glomerular epithelial detachment, not reduced charge density, correlates with proteinuria in adriamycin and puromycin nephrosis.

1989 • 108 citations

Increased Tyr phosphorylation of ZO-1 during modification of tight junctions between glomerular foot processes

1995 • 106 citations

Podocytic cytoskeletal disaggregation and basement-membrane detachment in puromycin aminonucleoside nephrosis.

1993 • 106 citations

A beta 1-integrin receptor for fibronectin in human kidney glomeruli.

1989 • 101 citations

INHIBITION OF LYMPHOCYTE BLASTOGENESIS BY PLASMA OF PATIENTS WITH MINIMAL-CHANGE NEPHROTIC SYNDROME

1976 • 100 citations

Distribution of beta 1 and beta 3 integrins in human fetal and adult kidney.

1990 • 99 citations

Development of tubular and glomerular cells of the kidney

1992 • 94 citations

Expression of drosophila's 27 kDa heat shock protein into rodent cells confers thermal resistance

1992 • 93 citations

Loss of mitotic activity and the expression of vimentin in glomerular epithelial cells of developing human kidneys

1993 • 91 citations

MAP 4: a microtubule-associated protein specific for a subset of tissue microtubules.

1984 • 90 citations

Variable expression of desmin in rat glomerular epithelial cells.

1990 • 88 citations

Reactive oxygen metabolites cause massive, reversible proteinuria and glomerular sieving defect without apparent ultrastructural abnormality.

1991 • 88 citations

Molecular Cloning, Expression, and Characterization of Podocalyxin-like Protein 1 from Rabbit as a Transmembrane Protein of Glomerular Podocytes and Vascular Endothelium

1995 • 87 citations

Glomerular epithelial abnormalities associated with the onset of proteinuria in aminonucleoside nephrosis.

1987 • 84 citations

Cellular receptors for matrix proteins in normal human kidney and human mesangial cells

1990 • 81 citations

Heat shock proteins HSP25, HSP60, HSP72, HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney

1996 • 80 citations

Altered expression of glomerular heat shock protein 27 in experimental nephrotic syndrome.

1996 • 71 citations

Identification of the lymphokine soluble immune response suppressor in urine of nephrotic children.

1985 • 69 citations

Expression of intermediate-sized filaments in developing and adult human kidney and in renal cell carcinoma.

1990 • 67 citations

Cytoskeleton ultrastructure of podocytes and glomerular endothelial cells in man and in the rat

1984 • 62 citations

I. Induction of proteinuria in the rat by a monoclonal antibody against SGP-115/107

1988 • 62 citations

THE MECHANISM OF A FORM OF GLOMERULONEPHRITIS*

1942 • 61 citations

Unaltered anionic sites of glomerular basement membrane in aminonucleoside nephrosis

1984 • 61 citations

Glomerular basement membrane anionic charge site changes early in aminonucleoside nephrosis.

1986 • 60 citations

Expression of the 25-kDa Heat-Shock Protein (HSP27) Correlates with Resistance to the Toxicity of Cadmium Chloride, Mercuric Chloride,-Platinum(II)-Diammine Dichloride, or Sodium Arsenite in Mouse Embryonic Stem Cells Transfected with Sense or Antisense HSP27 cDNA

1996 • 59 citations

Developmental expression of the nephritogenic antigen of monoclonal antibody 5-1-6.

1995 • 59 citations

Adhesion of rat glomerular epithelial cells to extracellular matrices: Role of β1 integrins

1992 • 59 citations

Podoendin. A new cell surface protein of the podocyte and endothelium.

1985 • 57 citations

Progressive renal failure--inability of podocytes to replicate and the consequences for development of glomerulosclerosis

1996 • 57 citations

Physicochemical Characterization of a Vascular Permeability Factor Produced by Con A-Stimulated Human Lymphocytes

1977 • 55 citations

Distribution of extracellular matrix receptors in various forms of glomerulonephritis

1995 • 55 citations

Renal localization of the constitutive 73-kDa heat-shock protein in normal and PAN rats

1992 • 52 citations

Cellular aspects of rabbit masugi nephritis

1972 • 48 citations

Heat Shock Proteins and the Kidney

1994 • 48 citations

Direct podocyte damage in the single nephron leads to albuminuria in vivo

1995 • 48 citations

Contractile proteins in podocytes: immunocytochemical localization of actin and alpha-actinin in normal and nephrotic rat kidneys

1991 • 46 citations

Ultrastructural study of the glomerular slit diaphragm in fresh unfixed kidneys by a quick-freezing method

1992 • 46 citations

Integrin receptors in the glomerulus: potential role in glomerular injury

1992 • 45 citations

Monoclonal antibodies against rat glomerular antigens: production and specificity.

1983 • 43 citations

Modulation of basement membrane component gene expression in glomeruli of aminonucleoside nephrosis.

1991 • 43 citations

A highly cationic protein in plasma and urine of children with steroid-responsive nephrotic syndrome

1989 • 40 citations

Filamentous actin bundles in the kidney

1984 • 39 citations

Determinants of glomerular hypofiltration in nephrotic patients with minimal change nephropathy.

1994 • 39 citations

Glomerular epithelial protein 1 and podocalyxin-like protein 1 in inflammatory glomerular disease (crescentic nephritis) in rabbit and man.

1996 • 39 citations

Changes in glomerular heparan sulfate in puromycin aminonucleoside nephrosis.

1987 • 38 citations

Cell-Matrix Adhesion Receptors: Relevance to Glomerular Pathology

1992 • 37 citations

CELLULAR ASPECTS OF RABBIT MASUGI NEPHRITIS

1979 • 37 citations

Transfer of Aminonucleoside Nephrosis by Renal Transplantation

1972 • 36 citations

Three-dimensional study of glomerular slit diaphragm by the quick-freezing and deep-etching replica method.

1990 • 34 citations

Alteration of glomerular permeability to macromolecules induced by cross-linking of beta 1 integrin receptors.

1996 • 34 citations

Steroid-sensitive mechanism of soluble immune response suppressor production in steroid-responsive nephrotic syndrome.

1987 • 34 citations

Food allergy and idiopathic nephrotic syndrome.

1989 • 32 citations

Alterations in proteoglycan metabolism in the nephrotic syndrome induced by the aminonucleoside of puromycin.

1984 • 32 citations

Microtubule-associated protein 3 (MAPЗ) expression in non-neuronal tissues

1990 • 31 citations

Very Late Activation-3 Integrin Is the Dominant β<sub>1</sub>-Integrin on the Glomerular Capillary Wall: An Immunofluorescence Study in Nephrotic Syndrome

1992 • 29 citations

Localization of 90-kDa heat shock protein in the kidney

1990 • 27 citations

Beta-1 Integrins in the Normal Human Glomerular Capillary Wall: An Immunoelectron Microscopy Study

1994 • 25 citations

Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney

1996 • 24 citations

Quantitative indexes of aminonucleoside-induced nephrotic syndrome.

1984 • 24 citations

Distribution of intramembrane particles and filipin-sterol complexes in plasma membranes of kidney. I. Corpuscle of Malpighi.

1982 • 24 citations

ACTIN FILAMENT ALTERATIONS IN GLOMERULAR EPITHELIAL CELLS OF ADRIAMYCIN-INDUCED NEPHROTIC RATS

1986 • 15 citations

Reversible hexadimethrine-induced alterations in glomerular structure and permeability.

1991 • 12 citations

Water and protein permeability is regulated by the glomerular epithelial slit diaphragm.

1994 • 11 citations

A plasma membrane antigen of rat glomerular epithelial cells. Antigenic determinants involving N-linked sugar residues in a 140-kilodalton sialoglycoprotein of the podocytes.

1990 • 9 citations

Purification of a mature form of 60kDa heat-shock protein (chaperonin homolog) from porcine kidney and its partial amino acid sequence

1992 • 8 citations

Identification of a processed protein related to the human chaperonins (hsp 60) protein in mammalian kidney

1992 • 7 citations

[Pathogenesis of the nephrotic syndrome].

1955 • 5 citations

The Detection of Effaced Podocytes by High Resolution Light Microscopy

1982 • 4 citations