Extracellular Mg2+ Modulates Slow Gating Transitions and the Opening of Drosophila Ether-à-Go-Go Potassium Channels

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Inactivation of the sodium channel. I. Sodium current experiments.

1977 • 1,509 citations

The biological chemistry of the elements: the inorganic chemistry of life

1992 • 1,298 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction Coupling

1973 • 978 citations

A family of potassium channel genes related to eag in Drosophila and mammals.

1994 • 960 citations

Inactivation of the sodium channel. II. Gating current experiments.

1977 • 943 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

Contribution of the S4 Segment to Gating Charge in the Shaker K+ Channel

1996 • 678 citations

Currents Related to Movement of the Gating Particles of the Sodium Channels

1973 • 664 citations

Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel

1996 • 654 citations

Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila

1987 • 645 citations

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

1996 • 603 citations

Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating

1996 • 598 citations

Shaker potassium channel gating. III: Evaluation of kinetic models for activation.

1994 • 512 citations

Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence

1991 • 507 citations

Transmembrane Movement of the Shaker K+ Channel S4

1996 • 496 citations

The Size of Gating Charge in Wild-Type and Mutant Shaker Potassium Channels

1992 • 422 citations

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

1988 • 396 citations

Evidence for voltage-dependent S4 movement in sodium channels

1995 • 396 citations

Potassium Ion Current in the Squid Giant Axon

1960 • 375 citations

A Distinct Potassium Channel Polypeptide Encoded by the Drosophila eag Locus

1991 • 361 citations

Characterizing Voltage-Dependent Conformational Changes in the K Channel with Fluorescence

1997 • 329 citations

Shaker potassium channel gating. II: Transitions in the activation pathway.

1994 • 299 citations

Activation of Shaker Potassium Channels

1998 • 277 citations

Voltage-sensing residues in the S4 region of a mammalian K+ channel

1991 • 275 citations

Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation

1994 • 275 citations

Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP

1993 • 240 citations

Hanatoxin Modifies the Gating of a Voltage-Dependent K+ Channel through Multiple Binding Sites

1997 • 239 citations

Mutations in the S4 Region Isolate the Final Voltage-dependent Cooperative Step in Potassium Channel Activation

1999 • 238 citations

Activation of Shaker Potassium Channels

1998 • 227 citations

Voltage-Dependent Proton Transport by the Voltage Sensor of the Shaker K+ Channel

1997 • 224 citations

Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels

1997 • 221 citations

Molecular Basis of Gating Charge Immobilization in Shaker Potassium Channels

1991 • 218 citations

Correlation between Charge Movement and Ionic Current during Slow Inactivation in Shaker K+ Channels

1997 • 186 citations

Functional expression of a rat homologue of the voltage gated either á go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart.

1994 • 183 citations

Uncharged S4 Residues and Cooperativity in Voltage-dependent Potassium Channel Activation

1998 • 160 citations

Gating of Shaker K+ channels: I. Ionic and gating currents

1994 • 159 citations

Transfer of twelve charges is needed to open skeletal muscle Na+ channels.

1995 • 153 citations

Extracellular Mg2+ regulates activation of rat eag potassium channel

1996 • 137 citations

Some kinetic and steady-state properties of sodium channels after removal of inactivation.

1981 • 121 citations

Potassium Currents Expressed from Drosophila and Mouse eag cDNAs in Xenopus Oocytes

1996 • 119 citations

Characterization of an eag‐like potassium channel in human neuroblastoma cells

1998 • 114 citations

Characterization of Ether-à-go-go Channels Present in Photoreceptors Reveals Similarity to IKx, a K+ Current in Rod Inner Segments

1998 • 88 citations

Allosteric Effects of Permeating Cations on Gating Currents during K+ Channel Deactivation

1997 • 60 citations

Role of the S3-S4 Linker in Shaker Potassium Channel Activation

1997 • 58 citations

Transfer of Voltage Independence from a Rat Olfactory Channel to the Drosophila Ether-à-go-go K+ Channel

1997 • 55 citations

Gating currents of the cloned delayed-rectifier K+ channel DRK1.

1993 • 42 citations

Individual Subunits Contribute Independently to Slow Gating of Bovine EAG Potassium Channels

1999 • 38 citations

How Does an Ion Channel Sense Voltage?

1997 • 34 citations

Potassium ion currents in the crayfish giant axon. Dynamic characteristics

1981 • 24 citations