A Permeant Ion Binding Site Located between Two Gates of the Shaker K+ Channel

Ionic channels of excitable membranes

1985 • 7,199 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Molecular cloning (2nd Ed)

1989 • 1,191 citations

Ionic channels of excitable membranes

1985 • 1,185 citations

The potassium permeability of a giant nerve fibre

1955 • 1,094 citations

Mutations in the K+ channel signature sequence

1994 • 828 citations

Mutations Affecting Internal TEA Blockade Identify the Probable Pore-Forming Region of a K ⁺ Channel

1991 • 634 citations

Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.

1993 • 582 citations

Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K ⁺ Channels

1990 • 569 citations

Negative Conductance Caused by Entry of Sodium and Cesium Ions into the Potassium Channels of Squid Axons

1972 • 554 citations

A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K ⁺ Channels

1992 • 479 citations

Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

1996 • 451 citations

The aromatic binding site for tetraethylammonium ion on potassium channels

1992 • 446 citations

Alteration of ionic selectivity of a K+ channel by mutation of the H5 region

1991 • 445 citations

Revealing the Architecture of a K ⁺ Channel Pore Through Mutant Cycles with a Peptide Inhibitor

1995 • 434 citations

Exchange of Conduction Pathways Between Two Related K ⁺ Channels

1991 • 387 citations

Modulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms

1995 • 379 citations

Mutant Potassium Channels with Altered Binding of Charybdotoxin, a Pore-Blocking Peptide Inhibitor

1989 • 351 citations

Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel

1991 • 341 citations

The Inner Quaternary Ammonium Ion Receptor in Potassium Channels of the Node of Ranvier

1972 • 302 citations

An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding

1994 • 289 citations

Spatial Localization of the K+ Channel Selectivity Filter by Mutant Cycle–Based Structure Analysis

1996 • 288 citations

The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition

1994 • 286 citations

Discrete Ba2+ block as a probe of ion occupancy and pore structure in the high-conductance Ca2+ -activated K+ channel.

1988 • 285 citations

The internal quaternary ammonium receptor site of Shaker potassium channels

1993 • 273 citations

Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins

1995 • 253 citations

Potassium blocks barium permeation through a calcium-activated potassium channel.

1988 • 227 citations

Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor

1990 • 220 citations

Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K ⁺ Channel

1996 • 218 citations

Block of squid axon K channels by internally and externally applied barium ions.

1982 • 218 citations

Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore

1994 • 193 citations

Silver as a Probe of Pore-Forming Residues in a Potassium Channel

1995 • 182 citations

A Strongly Interacting Pair of Residues on the Contact Surface of Charybdotoxin and a Shaker K+ Channel

1996 • 131 citations

Relief of Na+ block of Ca2+-activated K+ channels by external cations.

1984 • 127 citations

The S4–S5 loop contributes to the ion-selective pore of potassium channels

1993 • 127 citations

Coupling of voltage-dependent gating and Ba++ block in the high-conductance, Ca++-activated K+ channel.

1987 • 121 citations

K+ pore structure revealed by reporter cysteines at inner and outer surfaces

1995 • 112 citations

Side-chain accessibilities in the pore of a K+ channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis

1995 • 101 citations

Mutations in the pore region of ROMK enhance Ba2+ block

1996 • 78 citations

A single nonpolar residue in the deep pore of related K+ channels acts as a K+:Rb+ conductance switch

1992 • 75 citations

Trapping single ions inside single ion channels

1987 • 66 citations

Structural Model of the Outer Vestibule and Selectivity Filter of the Shaker Voltage-gated K + Channel

1996 • 65 citations

Pore mutations in Shaker K+ channels distinguish between the sites of tetraethylammonium blockade and C‐type inactivation.

1997 • 64 citations

The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway

1994 • 51 citations

Comparison of H5, S6, and H5-S6 exchanges on pore properties of voltage-dependent K+ channels.

1994 • 51 citations

External barium block of Shaker potassium channels: evidence for two binding sites.

1995 • 47 citations

Multi-ion occupancy alters gating in high-conductance, Ca(2+)-activated K+ channels.

1991 • 45 citations

Unidirectional K+ fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes.

1996 • 44 citations

Molecular determinants of external barium block in Shaker potassium channels

1996 • 31 citations

Hydrophobic mutations alter the movement of Mg2+ in the pore of voltage-gated potassium channels

1996 • 15 citations