Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells

Cisplatin: mode of cytotoxic action and molecular basis of resistance

2003 • 3,150 citations

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

2002 • 863 citations

A Delicate Balance: Homeostatic Control of Copper Uptake and Distribution

1999 • 715 citations

Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.

1996 • 623 citations

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

1991 • 376 citations

Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.

2000 • 327 citations

Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.

2002 • 287 citations

The Copper Transporter CTR1 Regulates Cisplatin Uptake in Saccharomyces cerevisiae

2002 • 227 citations

Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux

1995 • 178 citations

Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines.

1997 • 176 citations

Modulation of the Cellular Pharmacology of Cisplatin and Its Analogs by the Copper Exporters ATP7A and ATP7B

2004 • 156 citations

Copper‐transporting P‐type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: Comparative analysis with expression of MDR1, MRP1, MRP2, LRP and BCRP

2002 • 140 citations

Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients.

2003 • 134 citations

Rapid Emergence of Acquired cis-Diamminedichloroplatinum(II) Resistance in an In Vivo Model of Human Ovarian Carcinoma

1990 • 134 citations

The Copper Export Pump ATP7B Modulates the Cellular Pharmacology of Carboplatin in Ovarian Carcinoma Cells

2003 • 121 citations

The events that occur when cisplatin encounters cells

1996 • 115 citations

Correction of the Copper Transport Defect of Menkes Patient Fibroblasts by Expression of the Menkes and Wilson ATPases

1998 • 114 citations

New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy

2000 • 111 citations

A Golgi localization signal identified in the Menkes recombinant protein

1998 • 94 citations

Confocal Microscopic Analysis of the Interaction between Cisplatin and the Copper Transporter ATP7B in Human Ovarian Carcinoma Cells

2004 • 93 citations

Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human oral squamous cell carcinoma treated with cisplatin

2003 • 82 citations

The cellular pharmacology of oxaliplatin resistance

2002 • 71 citations

Cross-resistance to cisplatin in cells with acquired resistance to copper

2004 • 69 citations

Intracellular localization of the Menkes and Wilson's disease proteins and their role in intracellular copper transport

1999 • 66 citations

Expression and cisplatin sensitivity of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinoma cell lines

2001 • 66 citations

Copper‐transporting P‐Type Adenosine Triphosphatase (ATP7B) Is Expressed in Human Breast Carcinoma

2002 • 55 citations

Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human gastric carcinoma

2002 • 54 citations

Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma

2003 • 49 citations

Role of Membrane Ion Transport in Cisplatin Accumulation

1991 • 20 citations