Confocal Microscopic Analysis of the Interaction between Cisplatin and the Copper Transporter ATP7B in Human Ovarian Carcinoma Cells

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

1993 • 1,905 citations

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

1993 • 1,345 citations

Cellular accumulation of the anticancer agent cisplatin: A review

1993 • 557 citations

Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.

1993 • 517 citations

Isolation and Characterization of a Human Liver cDNA as a Candidate Gene for Wilson Disease

1993 • 501 citations

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

1991 • 376 citations

Short-termcis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells

1990 • 357 citations

Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.

2000 • 327 citations

Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae

1997 • 324 citations

Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper.

2002 • 287 citations

Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion

2000 • 260 citations

Use of isogenic human cancer cells for high-throughput screening and drug discovery

2001 • 228 citations

Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation

1998 • 225 citations

Characterization of Mouse Embryonic Cells Deficient in the Ctr1 High Affinity Copper Transporter

2002 • 223 citations

GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation.

1994 • 204 citations

Hepatocyte-specific localization and copper-dependent trafficking of the Wilson’s disease protein in the liver

1999 • 190 citations

Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas.

2000 • 174 citations

Hepatic copper metabolism: Insights from genetic disease

2003 • 170 citations

Restoration of Holoceruloplasmin Synthesis in LEC Rat after Infusion of Recombinant Adenovirus Bearing WND cDNA

1998 • 167 citations

Expression, Purification, and Metal Binding Properties of the N-terminal Domain from the Wilson Disease Putative Copper-transporting ATPase (ATP7B)

1997 • 160 citations

Cell-mediated immunity to human malignant cells

1972 • 148 citations

The Copper Export Pump ATP7B Modulates the Cellular Pharmacology of Carboplatin in Ovarian Carcinoma Cells

2003 • 121 citations

Copper Specifically Regulates Intracellular Phosphorylation of the Wilson's Disease Protein, a Human Copper-transporting ATPase

2001 • 111 citations

New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy

2000 • 111 citations

Localization of the Wilson's disease protein in human liver

1999 • 103 citations

Differential uptake of cis-diamminedichloroplatinum (II) by sensitive and resistant murine L1210 leukemia cells.

1987 • 102 citations

Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments

1997 • 100 citations

Decreased accumulation of [14c]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake

2000 • 98 citations

Resistance to cisplatin.

1999 • 93 citations

Modulation of cis‐diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3‐isobutyl‐1‐methylxanthine in sensitive and resistant human ovarian carcinoma cells

1991 • 93 citations

Role of the Na+, K(+)-adenosine triphosphatase in the accumulation of cis-diamminedichloroplatinum(II) in human ovarian carcinoma cells.

1991 • 88 citations

Characteristics of five human tumor cell lines and sublines resistant to cis‐diamminedichloroplatinum(II)

1991 • 87 citations

Enrichment for DNA mismatch repair-deficient cells during treatment with cisplatin

1998 • 80 citations

Sensitivity to novel platinum compounds of panels of human lung cancer cell lines with acquired and inherent resistance to cisplatin

1993 • 78 citations

Cross-resistance to cisplatin in cells with acquired resistance to copper

2004 • 69 citations

Characterization of resistance mechanisms to cis-diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro.

1994 • 53 citations

Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease Yamaguchi Y, Heiny ME, Gitlin JD. Biochem Biophys Res Commun 1993;197:271–277

1994 • 46 citations

Mechanisms of acquired resistance to cisplatin

1994 • 40 citations

Ultrastructural morphology and localisation of cisplatin-induced platinum–DNA adducts in a cisplatin-sensitive and -resistant human small cell lung cancer cell line using electron microscopy

2001 • 37 citations

Cisplatin efflux, binding and intracellular pH in the HTB56 human lung adenocarcinoma cell line and the E-8/0.7 cisplatin-resistant variant

1999 • 35 citations

Copper Does Not Alter the Intracellular Distribution of ATP7B, a Copper-Transporting ATPase

2000 • 31 citations

Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line

2003 • 27 citations

Role of Membrane Ion Transport in Cisplatin Accumulation

1991 • 20 citations

X-ray microanalysis and ultrastructural localization of cisplatin in liver and kidney of the rat.

1985 • 17 citations

X-ray microanalysis and electron microscopy of platinum complex in the epithelium of proximal renal tubules of the cisplatin administered rabbits

1986 • 13 citations

Experimental Ultrastructural and X-Ray Microanalysis Study of Cisplatin in the Rat: Intracellular Localization of Platinum

1983 • 13 citations

High-titer MSCV-based retrovirus generated in the pCL acute virus packaging system confers sustained gene expression in vivo

1998 • 10 citations

Preferential nucleolar localization of Cis-DDP in human fibroblasts.

1983 • 9 citations