Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

1998 • 5,253 citations

Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation

1985 • 994 citations

Cisplatin

1984 • 942 citations

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

1994 • 660 citations

Biochemical Characterization of the Human Copper Transporter Ctr1

2002 • 575 citations

Cellular accumulation of the anticancer agent cisplatin: A review

1993 • 557 citations

h CTR1 : A human gene for copper uptake identified by complementation in yeast

1997 • 541 citations

Cisplatin and DNA repair in cancer chemotherapy

1995 • 506 citations

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae.

1994 • 495 citations

Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development

2001 • 435 citations

The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.

1994 • 407 citations

Clinical Perspectives on Platinum Resistance

2000 • 347 citations

Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance.

2000 • 327 citations

MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast.

1993 • 274 citations

Molecular Characterization of a Putative Arabidopsis thaliana Copper Transporter and Its Yeast Homologue

1995 • 266 citations

Copper-specific Transcriptional Repression of Yeast Genes Encoding Critical Components in the Copper Transport Pathway

1997 • 249 citations

A widespread transposable element masks expression of a yeast copper transport gene.

1996 • 248 citations

Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis.

1996 • 209 citations

Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant

2000 • 198 citations

Metalloregulation of FRE1 and FRE2Homologs in Saccharomyces cerevisiae

1998 • 194 citations

Homeostatic Regulation of Copper Uptake in Yeast via Direct Binding of MAC1 Protein to Upstream Regulatory Sequences ofFRE1 and CTR1

1997 • 180 citations

Ixr1, a Yeast Protein That Binds to Platinated DNA and Confers Sensitivity to Cisplatin

1993 • 177 citations

Enhanced transport of anticancer agents and leukotriene C₄ by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)

1999 • 157 citations

Effect of cis -Platinum(II)Diamminodichloride on Wild Type and Deoxyribonucleic Acid Repair-Deficient Mutants of Escherichia coli

1973 • 137 citations

Increased sensitivity of UV-repair-deficient human cells to DNA bound platinum products which unlike thymine dimers are not recognized by an endonuclease extracted from Micrococcus luteus

1978 • 131 citations

The Fe(II) permease Fet4p functions as a low affinity copper transporter and supports normal copper trafficking in Saccharomyces cerevisiae

2000 • 126 citations

Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II)

1985 • 105 citations

A series of protein phosphatase gene disruptants inSaccharomyces cerevisiae

1999 • 104 citations

The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast

1996 • 103 citations

Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae.

1993 • 87 citations

γ-Glutamylcysteine Synthetase Gene Overexpression Results in Increased Activity of the ATP-Dependent Glutathione S-Conjugate Export Pump and Cisplatin Resistance

1995 • 72 citations

Bleomycin and sister-chromatid exchange in human lymphocyte chromosomes

1978 • 62 citations

Two Nuclear Proteins, Cin5 and Ydr259c, Confer Resistance to Cisplatin inSaccharomyces cerevisiae

2001 • 55 citations

SKY1 is involved in cisplatin-induced cell kill in Saccharomyces cerevisiae, and inactivation of its human homologue, SRPK1, induces cisplatin resistance in a human ovarian carcinoma cell line.

2001 • 53 citations

A Genome-Wide Screening in Saccharomyces cerevisiae for Genes That Confer Resistance to the Anticancer Agent Cisplatin

2000 • 40 citations

Loss of DNA mismatch repair due to knockout of MSH2 or PMS2 results in resistance to cisplatin and carboplatin

1997 • 34 citations