Correction of the Copper Transport Defect of Menkes Patient Fibroblasts by Expression of the Menkes and Wilson ATPases

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene

1993 • 1,905 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

1993 • 1,345 citations

Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

1993 • 720 citations

Isolation of a partial candidate gene for Menkes disease by positional cloning

1993 • 690 citations

Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of regulated trafficking.

1996 • 623 citations

The Wilson disease gene: spectrum of mutations and their consequences

1995 • 563 citations

Isolation and Characterization of a Human Liver cDNA as a Candidate Gene for Wilson Disease

1993 • 501 citations

Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae

1997 • 324 citations

Bacteriotherapy for chronic relapsing Clostridium difficile in six patients

1989 • 291 citations

Cellular Copper Transport

1995 • 281 citations

N-terminal Domains of Human Copper-transporting Adenosine Triphosphatases (the Wilson's and Menkes Disease Proteins) Bind Copper Selectively in Vivo and in Vitro with Stoichiometry of One Copper Per Metal-binding Repeat

1997 • 237 citations

Biochemical characterization and intracellular localization of the Menkes disease protein

1996 • 205 citations

Inflammatory Diseases and Copper

1982 • 191 citations

Copper transport and its alterations in Menkes and Wilson diseases

1997 • 186 citations

Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux

1995 • 178 citations

The toxic milk mouse is a murine model of Wilson disease

1996 • 178 citations

Menkes disease: a biochemical abnormality in cultured human fibroblasts.

1976 • 172 citations

Restoration of Holoceruloplasmin Synthesis in LEC Rat after Infusion of Recombinant Adenovirus Bearing WND cDNA

1998 • 167 citations

Localization of the Wilson’s disease protein product to mitochondria

1998 • 130 citations

COPPER INCORPORATION STUDIES ON CULTURED CELLS FOR PRENATAL DIAGNOSIS OF MENKES' DISEASE

1976 • 128 citations

Diverse mutations in patients with Menkes disease often lead to exon skipping.

1994 • 123 citations

Altered copper metabolism in cultured cells from human Menkes' syndrome and mottled mouse mutants

1980 • 121 citations

Immunocytochemical Localization of the Menkes Copper Transport Protein (ATP7A) to the Trans-Golgi Network

1997 • 120 citations

Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments

1997 • 100 citations

Identification of point mutations in 41 unrelated patients affected with Menkes disease.

1997 • 100 citations

Menkes disease: recent advances and new aspects.

1997 • 94 citations

Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters

1997 • 93 citations

Functional analysis and intracellular localization of the human menkes protein (MNK) stably expressed from a cDNA construct in Chinese hamster ovary cells (CHO-K1)

1998 • 89 citations

Intracellular distribution of the Wilson's disease gene product (atpase7b) afterin vitro andin vivo exogenous expression in hepatocytes from the LEC rat, an animal model of Wilson's disease

1998 • 71 citations

Adenosine triphosphate-dependent copper transport in isolated rat liver plasma membranes.

1995 • 42 citations

Analysis of hepatic copper, zinc, metallothionein and metallothionein‐Ia mRNA in developing sheep

1990 • 28 citations

Eukaryotic Expression Vectors That Replicate to Low Copy Number in Bacteria: Transient Expression of the Menkes Protein

1998 • 17 citations

7 Menkes and Wilson Diseases

1995 • 13 citations

Immortalization of human fibroblasts by liposome-mediated transfer of SV40 early region genes

1995 • 8 citations