Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

mTOR Signaling in Growth Control and Disease

2012 • 7,638 citations

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

2011 • 6,060 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 4,142 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 3,652 citations

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

2008 • 3,474 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

2011 • 2,623 citations

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

2011 • 2,566 citations

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

2008 • 2,551 citations

Molecular mechanisms of mTOR-mediated translational control

2009 • 2,372 citations

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

2010 • 2,310 citations

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

2010 • 2,234 citations

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

2009 • 1,910 citations

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

2009 • 1,876 citations

Autophagy and Metabolism

2010 • 1,842 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

2010 • 1,785 citations

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

2012 • 1,685 citations

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 • 1,631 citations

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

2009 • 1,607 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

Mechanisms and functions of p38 MAPK signalling

2010 • 1,503 citations

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

2011 • 1,487 citations

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

2009 • 1,421 citations

A unifying model for mTORC1-mediated regulation of mRNA translation

2012 • 1,364 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

2004 • 1,307 citations

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

2006 • 1,293 citations

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

2003 • 1,285 citations

Regulation of TORC1 by Rag GTPases in nutrient response

2008 • 1,260 citations

The translational landscape of mTOR signalling steers cancer initiation and metastasis

2012 • 1,237 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

Phosphorylation and Functional Inactivation of TSC2 by Erk

2005 • 1,229 citations

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

2008 • 1,222 citations

PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase

2007 • 1,176 citations

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

2008 • 1,171 citations

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 • 1,160 citations

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

2002 • 1,147 citations

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

2007 • 1,132 citations

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

2011 • 1,082 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

mTOR signaling: At the crossroads of plasticity, memory and disease

2009 • 1,053 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

2012 • 864 citations

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

2011 • 841 citations

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

2010 • 806 citations

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

2005 • 744 citations

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

2012 • 738 citations

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

2004 • 737 citations

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

2011 • 726 citations

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

2013 • 712 citations

Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling

2008 • 660 citations

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

2013 • 656 citations

Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes

1995 • 654 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

Glutaminolysis Activates Rag-mTORC1 Signaling

2012 • 636 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

The regulation and function of Class III PI3Ks: novel roles for Vps34

2008 • 626 citations

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

2010 • 597 citations

Hypoxia-Induced Energy Stress Regulates mRNA Translation and Cell Growth

2006 • 597 citations

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

2011 • 578 citations

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

2011 • 561 citations

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

2012 • 560 citations

Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

2004 • 536 citations

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

2003 • 521 citations

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

2005 • 519 citations

Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis

2002 • 515 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

The updated biology of hypoxia-inducible factor

2012 • 509 citations

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

2013 • 466 citations

A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets

2003 • 460 citations

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

2011 • 458 citations

REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species

2002 • 456 citations

Disassembly and Reassembly of the Yeast Vacuolar H+-ATPase in Vivo

1995 • 454 citations

Regulation of TFEB and V-ATPases by mTORC1

2011 • 434 citations

Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

2005 • 432 citations

5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

2006 • 431 citations

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

2012 • 421 citations

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

2010 • 385 citations

Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner

2003 • 380 citations

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

2008 • 360 citations

The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses

2005 • 357 citations

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

2012 • 346 citations

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

2006 • 345 citations

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

2012 • 345 citations

Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency

2005 • 343 citations

The TOR pathway comes of age

2009 • 333 citations

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

2012 • 332 citations

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

2008 • 326 citations

The TOR and EGO Protein Complexes Orchestrate Microautophagy in Yeast

2005 • 321 citations

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

2011 • 320 citations

Common corruption of the mTOR signaling network in human tumors

2008 • 315 citations

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

2004 • 294 citations

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila

2008 • 293 citations

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

2007 • 253 citations

The multiple facets of mTOR in immunity

2009 • 252 citations

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

2010 • 251 citations

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

2010 • 248 citations

The multifaceted role of mTORC1 in the control of lipid metabolism

2012 • 236 citations

Novel G Proteins, Rag C and Rag D, Interact with GTP-binding Proteins, Rag A and Rag B

2001 • 229 citations

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

2012 • 222 citations

Tel2 Regulates the Stability of PI3K-Related Protein Kinases

2007 • 215 citations

Phosphatidylinositol 3-Kinase-Mediated Effects of Glucose on Vacuolar H⁺-ATPase Assembly, Translocation, and Acidification of Intracellular Compartments in Renal Epithelial Cells

2005 • 204 citations

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

2009 • 201 citations

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

2012 • 197 citations

Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression

2012 • 193 citations

Localization of Rheb to the endomembrane is critical for its signaling function

2006 • 185 citations

Impaired α _IIb β ₃ Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

2010 • 185 citations

Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis

2009 • 184 citations

Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite Phosphorylation

2009 • 181 citations

The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation

1997 • 178 citations

mTOR links oncogenic signaling to tumor cell metabolism

2011 • 175 citations

The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy

2012 • 173 citations

The p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3

2003 • 165 citations

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

2008 • 165 citations

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

2011 • 151 citations

Transcriptional Control of Cellular Metabolism by mTOR Signaling

2011 • 149 citations

Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase

2011 • 140 citations

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

2011 • 134 citations

PP2AT61ɛ Is an Inhibitor of MAP4K3 in Nutrient Signaling to mTOR

2010 • 122 citations

Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)

2011 • 102 citations

Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway

2005 • 100 citations

Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation

2011 • 94 citations

A Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1

2009 • 90 citations

2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma

2011 • 88 citations

Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis

2012 • 87 citations

SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

2012 • 84 citations

Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes

2007 • 83 citations

Nutrients differentially regulate multiple translation factors and their control by insulin

1999 • 78 citations

Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia

2011 • 76 citations

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1^,

2010 • 65 citations

MAP4K3 regulates body size and metabolism in Drosophila

2010 • 62 citations

Phosphorylation of Raptor by p38β Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation

2011 • 60 citations

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice

2006 • 56 citations

Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5′-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside

2009 • 54 citations

Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2

2012 • 40 citations

Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1

2001 • 38 citations

PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fcγ-receptor-stimulated ROS production in neutrophils

2011 • 36 citations

Palmitate Induced Insulin Resistance by PKCtheta-Dependent Activation of mTOR/S6K Pathway in C2C12 Myotubes

2010 • 35 citations

Phospholipase D and mTORC1: Nutrients Are What Bring Them Together

2012 • 34 citations

SP600125 negatively regulates the mammalian target of rapamycin via ATF4‐induced Redd1 expression

2008 • 30 citations

Metabolic Control by S6 Kinases Depends on Dietary Lipids

2012 • 23 citations

Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1

2001 • 23 citations

Oleate-mediated activation of phospholipase D and mammalian target of rapamycin (mTOR) regulates proliferation and rapamycin sensitivity of hepatocarcinoma cells

2011 • 17 citations