PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Targeting RAS signalling pathways in cancer therapy

2003 • 3,105 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

2006 • 2,463 citations

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

2005 • 2,090 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

2006 • 1,210 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor

2002 • 972 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

The Akt-mTOR tango and its relevance to cancer

2005 • 778 citations

Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 • 773 citations

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

2002 • 652 citations

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

2006 • 616 citations

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

2004 • 562 citations

Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation

2005 • 558 citations

Mutations in a signalling pathway

2005 • 551 citations

Oncogenic PI3K and its role in cancer

2005 • 505 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 491 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 460 citations

TSC2: filling the GAP in the mTOR signaling pathway

2003 • 406 citations

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

2005 • 384 citations

PDGF signaling in cells and mice

2004 • 377 citations

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

2006 • 345 citations

Oncogenic protein tyrosine kinases

2004 • 260 citations

Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

2005 • 228 citations

Human cancer, PTEN and the PI-3 kinase pathway

2004 • 222 citations

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

2002 • 207 citations

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease

2005 • 206 citations

Receptor Heterodimerization: Essential Mechanism for Platelet-Derived Growth Factor-Induced Epidermal Growth Factor Receptor Transactivation

2001 • 178 citations

Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance.

1990 • 177 citations

Efficacy of a rapamycin analog (CCI‐779) and IFN‐γ in tuberous sclerosis mouse models

2004 • 168 citations

Effects of Rapamycin in the Eker Rat Model of Tuberous Sclerosis Complex

2004 • 163 citations

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

2002 • 146 citations

Epidermal Growth Factor Receptor Mutations in Patients with Non–Small Cell Lung Cancer

2005 • 146 citations

Oncogenic protein tyrosine kinases

2004 • 133 citations

Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy.

1999 • 128 citations

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

2001 • 101 citations

Phosphorylation of Tuberin as a Novel Mechanism for Somatic Inactivation of the Tuberous Sclerosis Complex Proteins in Brain Lesions

2004 • 85 citations

mTOR and cancer: reason for dancing at the crossroads?

2005 • 72 citations

Estrogen-induced Smooth Muscle Cell Growth Is Regulated by Tuberin and Associated with Altered Activation of Platelet-derived Growth Factor Receptor-β and ERK-1/2

2004 • 69 citations

Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by α platelet-derived growth factor receptor

2005 • 67 citations

Transactivation of the Epidermal Growth Factor Receptor Is Involved in 12-O-Tetradecanoylphorbol-13-acetate-induced Signal Transduction

2001 • 61 citations

Perturbed IFN-γ-Jak-Signal Transducers and Activators of Transcription Signaling in Tuberous Sclerosis Mouse Models

2004 • 57 citations

Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth.

2003 • 34 citations

p73 Independent of c-Myc Represses Transcription of Platelet-derived Growth Factor β-Receptor through Interaction with NF-Y

2002 • 33 citations

Sp1 is a key regulator of the PDGF beta-receptor transcription.

2001 • 25 citations