Site-specific inhibition of RNA polymerase II preinitiation complex assembly by human cytomegalovirus IE86 protein

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Transcriptional repression of eukaryotic promoters

1989 • 481 citations

Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription

1992 • 379 citations

Structural analysis of the major immediate early gene of human cytomegalovirus

1984 • 342 citations

Family of proteins that interact with TFIID and regulate promoter activity

1991 • 319 citations

Activation of class II gene transcription by regulatory factors is potentiated by a novel activity

1991 • 318 citations

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

1987 • 317 citations

Separation and partial characterization of three functional steps in transcription initiation by human RNA polymerase II.

1985 • 311 citations

Organization and expression of the immediate early genes of human cytomegalovirus

1983 • 288 citations

Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1

1985 • 270 citations

Activation of the major immediate early gene of human cytomegalovirus by cis-acting elements in the promoter-regulatory sequence and by virus-specific trans-acting components

1985 • 245 citations

trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus

1988 • 237 citations

Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter

1987 • 223 citations

Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

1990 • 216 citations

Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region

1989 • 216 citations

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains

1990 • 197 citations

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID

1992 • 195 citations

Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site

1991 • 161 citations

A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2

1991 • 158 citations

The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site

1990 • 156 citations

The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex.

1991 • 154 citations

Repression of HIV-1 Transcription by a Cellular Protein

1991 • 151 citations

Advances in RNA polymerase II transcription

1992 • 149 citations

The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear localization signal

1991 • 146 citations

Modulation of interleukin 1 beta gene expression by the immediate early genes of human cytomegalovirus.

1990 • 144 citations

Predominant immediate-early transcripts of human cytomegalovirus AD 169

1984 • 137 citations

Human cytomegalovirus US3 and UL36-38 immediate-early proteins regulate gene expression

1992 • 134 citations

Regulated expression of the human cytomegalovirus pp65 gene: octamer sequence in the promoter is required for activation by viral gene products

1989 • 126 citations

Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer.

1987 • 123 citations

Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene

1988 • 121 citations

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.

1992 • 115 citations

A human cytomegalovirus early gene has three inducible promoters that are regulated differentially at various times after infection

1989 • 112 citations

The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter

1993 • 110 citations

An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter.

1993 • 109 citations

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter

1990 • 100 citations

Participation of two human cytomegalovirus immediate early gene regions in transcriptional activation of adenovirus promoters

1987 • 99 citations

Regulation and Tissue-Specific Expression of Human Cytomegalovirus

1990 • 95 citations

In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins.

1993 • 92 citations

Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding protein transcription factor IID.

1990 • 90 citations

Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus

1991 • 86 citations

Human cytomegalovirus IE86 protein interacts with promoter-bound TATA-binding protein via a specific region distinct from the autorepression domain

1993 • 81 citations

A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins

1991 • 74 citations

Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box

1993 • 71 citations

E2F Mediates Dihydrofolate Reductase Promoter Activation and Multiprotein Complex Formation in Human Cytomegalovirus Infection

1992 • 68 citations

A 10-base-pair element of the human immunodeficiency virus type 1 long terminal repeat (LTR) is an absolute requirement for transactivation by the human cytomegalovirus 72-kilodalton IE1 protein but can be compensated for by other LTR regions in transactivation by the 80-kilodalton IE2 protein

1992 • 65 citations

In Vivo and in Vitro Analysis of Transcriptional Activation Mediated by the Human Cytomegalovirus Major Immediate-Early Proteins

1993 • 64 citations

Functional analysis of the true late human cytomegalovirus pp28 upstream promoter: cis-acting elements and viral trans-acting proteins necessary for promoter activation

1992 • 47 citations

Human Cytomegalovirus Early Gene Expression

1990 • 45 citations

An isoform variant of the cytomegalovirus immediate-early auto repressor functions as a transcriptional activator

1992 • 43 citations

Enhancement of RNA polymerase II initiation complexes by a novel DNA control domain downstream from the cap site of the cytomegalovirus major immediate-early promoter

1991 • 41 citations

Modulation of T-cell activation through protein kinase C- or A-dependent signalling pathways synergistically increases human immunodeficiency virus long terminal repeat induction by cytomegalovirus immediate-early proteins

1991 • 34 citations

Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli

1988 • 31 citations