Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus–based lentiviral vector system

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

2003 • 3,480 citations

A role for Wnt signalling in self-renewal of haematopoietic stem cells

2003 • 2,131 citations

HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots

2002 • 1,772 citations

Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration

2003 • 1,310 citations

Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning

2002 • 1,136 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

The Molecular Basis of Blood Diseases.

1987 • 648 citations

Transduction of Human CD34 ⁺ Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors

1999 • 648 citations

Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin

2000 • 567 citations

Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy

2001 • 563 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Side effects of retroviral gene transfer into hematopoietic stem cells

2003 • 438 citations

Occurrence of leukaemia following gene therapy of X-linked SCID

2003 • 341 citations

Progression to the G₁b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells

1998 • 312 citations

Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates

2002 • 298 citations

Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein

2003 • 278 citations

Restriction of lentivirus in monkeys

2002 • 277 citations

Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism

2002 • 275 citations

Improved Gene Transfer Into Baboon Marrow Repopulating Cells Using Recombinant Human Fibronectin Fragment CH-296 in Combination With Interleukin-6, Stem Cell Factor, FLT-3 Ligand, and Megakaryocyte Growth and Development Factor

1998 • 262 citations

The level of mRNA encoding the amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction.

1996 • 241 citations

Polyclonal long-term repopulating stem cell clones in a primate model

2002 • 228 citations

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human β-globin gene transfer

2003 • 218 citations

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

2002 • 217 citations

Optimization of Fibronectin-Assisted Retroviral Gene Transfer into Human CD34⁺Hematopoietic Cells

1997 • 215 citations

Comparison of Various Envelope Proteins for Their Ability to Pseudotype Lentiviral Vectors and Transduce Primitive Hematopoietic Cells from Human Blood

2002 • 203 citations

Transduction of Human Progenitor Hematopoietic Stem Cells by Human Immunodeficiency Virus Type 1-Based Vectors Is Cell Cycle Dependent

1999 • 199 citations

Gene Transfer into Marrow Repopulating Cells: Comparison Between Amphotropic and Gibbon Ape Leukemia Virus Pseudotyped Retroviral Vectors in a Competitive Repopulation Assay in Baboons

1997 • 188 citations

Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells

2003 • 187 citations

Permanent and panerythroid correction of murine β thalassemia by multiple lentiviral integration in hematopoietic stem cells

2002 • 186 citations

Transduction of Human CD34+CD38- Bone Marrow and Cord Blood-Derived SCID-Repopulating Cells with Third-Generation Lentiviral Vectors

2000 • 182 citations

Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells

2003 • 173 citations

The degree of phenotypic correction of murine β-thalassemia intermedia following lentiviral-mediated transfer of a human γ-globin gene is influenced by chromosomal position effects and vector copy number

2003 • 159 citations

Critical Factors Influencing Stable Transduction of Human CD34+ Cells with HIV-1-Derived Lentiviral Vectors

2000 • 156 citations

Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer

1998 • 143 citations

Human and Simian Immunodeficiency Virus Capsid Proteins Are Major Viral Determinants of Early, Postentry Replication Blocks in Simian Cells

2002 • 138 citations

Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein

2000 • 135 citations

Enhanced Host Defense After Gene Transfer in the Murine p47phox-Deficient Model of Chronic Granulomatous Disease

1997 • 133 citations

Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

2003 • 126 citations

Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous Disease

1997 • 124 citations

Peripheral blood CD34+ cells differ from bone marrow CD34+ cells in Thy- 1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte colony-stimulating factor and/or stem cell factor

1996 • 121 citations

Protection and in Vivo Selection of Hematopoietic Stem Cells Using Temozolomide, O6-Benzylguanine, and an Alkyltransferase-Expressing Retroviral Vector

2001 • 119 citations

Methylguanine methyltransferase–mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

2003 • 119 citations

Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells

1998 • 110 citations

Marking and Gene Expression by a Lentivirus Vector in Transplanted Human and Nonhuman Primate CD34⁺Cells

2000 • 109 citations

High Levels of Transduction of Human Dendritic Cells with Optimized SIV Vectors

2002 • 106 citations

Avoidance of stimulation improves engraftment of cultured and retrovirally transduced hematopoietic cells in primates

2001 • 105 citations

Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables

1999 • 103 citations

Retroviral-Mediated Gene Transfer of gp91phox Into Bone Marrow Cells Rescues Defect in Host Defense Against Aspergillus fumigatus in Murine X-Linked Chronic Granulomatous Disease

1997 • 103 citations

Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells

2002 • 103 citations

Genetic and Biological Comparisons of Pathogenic and Nonpathogenic Molecular Clones of Simian Immunodeficiency Virus (SIV_MAC)

1992 • 91 citations

Stable and functional lymphoid reconstitution of common cytokine receptor γ chain deficient mice by retroviral-mediated gene transfer

2000 • 89 citations

HIV-1-Derived Lentiviral Vectors

2002 • 86 citations

Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs

2002 • 84 citations

Distinct hematopoietic stem/progenitor cell populations are responsible for repopulating NOD/SCID mice compared with nonhuman primates

2003 • 77 citations

Lentivirus Vector-Mediated Hematopoietic Stem Cell Gene Transfer of Common Gamma-Chain Cytokine Receptor in Rhesus Macaques

2001 • 71 citations

Sustained multilineage gene persistence and expression in dogs transplanted with CD34+ marrow cells transduced by RD114-pseudotype oncoretrovirus vectors

2001 • 71 citations

Defects in T-cell–mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector–mediated gene transfer into repopulating hematopoietic cells

2003 • 66 citations

Lentivirus-mediated gene transfer into hematopoietic repopulating cells in baboons

2002 • 60 citations

Induction of cytotoxic T-lymphocyte responses to enhanced green and yellow fluorescent proteins after myeloablative conditioning

2003 • 59 citations

Lymphoid Development and Function in X-Linked Severe Combined Immunodeficiency Mice after Stem Cell Gene Therapy

2000 • 57 citations

Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMTP140K into hematopoietic stem cells

2002 • 57 citations

Retroviral transduction efficiency of G-CSF+SCF–mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L–mobilized cells in nonhuman primates

2003 • 52 citations

High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34+ cells

2000 • 48 citations

Lentiviral Vectors Derived from Simian Immunodeficiency Virus

2002 • 40 citations

Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients

2003 • 36 citations

Scaffold attachment region–containing retrovirus vectors improve long-term proviral expression after transplantation of GFP-modified CD34+ baboon repopulating cells

2003 • 31 citations

Development of an Rev-Independent, Minimal Simian Immunodeficiency Virus-Derived Vector System

2001 • 29 citations

Expression from Second-Generation Feline Immunodeficiency Virus Vectors Is Impaired in Human Hematopoietic Cells

2002 • 28 citations

Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells

2003 • 27 citations

Retroviral Transduction and Engraftment Ability of Primate Hematopoietic Progenitor and Stem Cells Transduced Under Serum-Free versus Serum-Containing Conditions

2002 • 20 citations

Direct comparison of RD114-pseudotyped versus amphotropic-pseudotyped retroviral vectors for transduction of rhesus macaque long-term repopulating cells

2003 • 15 citations

In vivo selection to improve gene therapy of hematopoietic disorders.

2002 • 8 citations

SIV Vectors

2003 • 2 citations

393. Pseudotyping Retroviral Vectors with RD114 or FeLV-C Envelopes Improves Transduction of Human HSC

2003 • 1 citations

399. Extended β-Globin Locus Control Region Enhancer Elements Promote Consistent Therapeutic Expression of a γ-Globin Lentiviral Vector in Murine β-Thalassemia in the Context of Reduced Vector Copy Number

2003 • 1 citations

Deleted Work

1955 • 0 citations