Methylguanine methyltransferase–mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

Randomized Trial of Dose-Dense Versus Conventionally Scheduled and Sequential Versus Concurrent Combination Chemotherapy as Postoperative Adjuvant Treatment of Node-Positive Primary Breast Cancer: First Report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741

2003 • 1,525 citations

Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning

2002 • 1,136 citations

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

2000 • 943 citations

Stable Mixed Hematopoietic Chimerism in DLA-Identical Littermate Dogs Given Sublethal Total Body Irradiation Before and Pharmacological Immunosuppression After Marrow Transplantation

1997 • 633 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

Conventional-Dose Chemotherapy Compared with High-Dose Chemotherapy plus Autologous Hematopoietic Stem-Cell Transplantation for Metastatic Breast Cancer

2000 • 474 citations

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.

2000 • 335 citations

Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells

2000 • 280 citations

Improved Gene Transfer Into Baboon Marrow Repopulating Cells Using Recombinant Human Fibronectin Fragment CH-296 in Combination With Interleukin-6, Stem Cell Factor, FLT-3 Ligand, and Megakaryocyte Growth and Development Factor

1998 • 262 citations

Ex Vivo Expansion of Genetically Marked Rhesus Peripheral Blood Progenitor Cells Results in Diminished Long-Term Repopulating Ability

1998 • 257 citations

Polyclonal long-term repopulating stem cell clones in a primate model

2002 • 228 citations

Phase II Trial of Carmustine Plus O⁶-Benzylguanine for Patients With Nitrosourea-Resistant Recurrent or Progressive Malignant Glioma

2002 • 191 citations

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

2003 • 138 citations

Highly efficient gene transfer into cord blood nonobese diabetic/severe combined immunodeficiency repopulating cells by oncoretroviral vector particles pseudotyped with the feline endogenous retrovirus (RD114) envelope protein

2000 • 135 citations

Successful treatment of murine β-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

2003 • 126 citations

Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.

2000 • 124 citations

Limiting numbers of G156A O6-methylguanine–DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection

2000 • 121 citations

Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells

2002 • 103 citations

Characterization of Monoclonal Antibodies That Recognize Canine CD34

1998 • 95 citations

Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantation

2000 • 90 citations

Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs

2002 • 84 citations

DLA‐DRB1 and DLA‐DQB1 histocompatibility typing by PCR‐SSCP and sequencing

1998 • 78 citations

Pharmacologically regulated in vivo selection in a large animal

2002 • 75 citations

Retroviral Marking and Transplantation of Rhesus Hematopoietic Cells by Nonmyeloablative Conditioning

1999 • 75 citations

Sustained multilineage gene persistence and expression in dogs transplanted with CD34+ marrow cells transduced by RD114-pseudotype oncoretrovirus vectors

2001 • 71 citations

Lentivirus-mediated gene transfer into hematopoietic repopulating cells in baboons

2002 • 60 citations

The Use of Granulocyte Colony-Stimulating Factor During Retroviral Transduction on Fibronectin Fragment CH-296 Enhances Gene Transfer Into Hematopoietic Repopulating Cells in Dogs

1999 • 59 citations

Phase I Study of Temozolomide in Relapsed/Refractory Acute Leukemia

2002 • 50 citations

Pharmacologically regulated cell therapy

2001 • 45 citations

Progress in the Use of Gene Transfer Methods to Treat Genetic Blood Diseases

2000 • 45 citations

Improved gene transfer into canine hematopoietic repopulating cells using CD34-enriched marrow cells in combination with a gibbon ape leukemia virus–pseudotype retroviral vector

1999 • 43 citations

Novel Bicistronic Retroviral Vector Expressingγ-Glutamylcysteine Synthetase and the Multidrug Resistance Protein 1 (MRP1) Protects Cells from MRP1-Effluxed Drugs and Alkylating Agents

2001 • 20 citations

Outpatient Allografting in Hematologic Malignancies and Nonmalignant Disorders — Applying Lessons Learned in the Canine Model to Humans

2002 • 11 citations

Progress towards hematopoietic stem cell gene therapy.

2000 • 6 citations

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