Modulation of lipopolysaccharide-induced production of tumor necrosis factor, interleukin 1, and interleukin 6 by synthetic precursor Ia of lipid A

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Biology of interleukin 1

1988 • 1,547 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

1984 • 1,042 citations

Production of Malignancy in Vitro. IV. The Mouse Fibroblast Cultures and Changes Seen in the Living Cells

1943 • 843 citations

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

1989 • 651 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Cytokines as communication signals between leukocytes and endothelial cells

1989 • 528 citations

Electrodialysis of Lipopolysaccharides and Their Conversion to Uniform Salt Forms

1975 • 359 citations

Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages.

1989 • 353 citations

Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man.

1989 • 323 citations

The interleukins ¹

1989 • 276 citations

IL-1 induction-capacity of defined lipopolysaccharide partial structures.

1989 • 269 citations

Interleukin 1, interleukin 6 and tumor necrosis factor in infection, inflammation and immunity

1988 • 252 citations

Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.

1988 • 247 citations

Interaction of Lipopolysaccharides and Lipid A with Complement

1971 • 239 citations

Use of freeze-dried paraffin-embedded sections for immunohistologic staining with monoclonal antibodies.

1985 • 208 citations

Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS

1990 • 169 citations

Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide

1989 • 157 citations

Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo.

1990 • 145 citations

Preparation and properties of a standardized lipopolysaccharide from salmonella abortus equi (Novo-Pyrexal).

1979 • 143 citations

Isolation and Subfractionation of Human Peripheral Blood Mononuclear Cells (PBMC) by Density Gradient Centrifugation on Percoll

1984 • 122 citations

Induction of human interleukin 1 by bacterial and synthetic lipid A

1986 • 120 citations

Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression.

1989 • 116 citations

Investigation into the fluidity of lipopolysaccharide and free lipid A membrane systems by Fourier‐transform infrared spectroscopy and differential scanning calorimetry

1990 • 106 citations

Chemical synthesis of phosphorylated tetraacyl disaccharide corresponding to a biosynthetic precursor of lipid A

1984 • 104 citations

Deacylated lipopolysaccharide inhibits neutrophil adherence to endothelium induced by lipopolysaccharide in vitro.

1987 • 96 citations

[38] Isolation of fibroblasts from patients

1979 • 82 citations

Induction of Tumor Necrosis Factor-Alpha Release by Lipopolysaccharide and Defined Lipopolysaccharide Partial Structures

1989 • 80 citations

Immunohistologic assessment of cytokine production of infiltrating cells in various forms of leprosy.

1990 • 73 citations

Endotoxic-lipopolysaccharide-specific binding proteins on lymphoid cells of various animal species: association with endotoxin susceptibility

1989 • 72 citations

Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin

1973 • 65 citations

Monoclonal Antibodies to Human Tumor Necrosis Factors Alpha and Beta: Application for Affinity Purification, Immunoassays, and as Structural Probes

1987 • 63 citations

Deacylated lipopolysaccharide inhibits plasminogen activator inhibitor-1, prostacyclin, and prostaglandin E2 induction by lipopolysaccharide but not by tumor necrosis factor-alpha.

1990 • 55 citations

Interleukin 1 secretion by human monocytes stimulated by the isolated polysaccharide region of the Bordetella pertussis endotoxin

1984 • 54 citations

Highly purified lipid X is devoid of immunostimulatory activity. Isolation and characterization of immunostimulating contaminants in a batch of synthetic lipid X.

1990 • 43 citations

Lipid X ameliorates pulmonary hypertension and protects sheep from death due to endotoxin

1987 • 40 citations

Detection of Interleukin 1 with Human Dermal Fibroblasts

1989 • 39 citations

Lipid X protects mice against fatal Escherichia coli infection

1988 • 35 citations

Suppressive effect of lipid A partial structures on lipopolysaccharide or lipid A-induced release of interleukin 1 by human monocytes

1990 • 28 citations

Involvement of the LPS receptor in the induction of interleukin-1 in human monocytes stimulated with endotoxins

1987 • 19 citations

Functional and Molecular Characterization of a Monoclonal Antibody against the 165–186 Peptide of Human 1β

1989 • 18 citations

A Two-Step Mechanism for the Interaction of Re Lipopolysaccharide with Erythrocyte Membranes

1984 • 15 citations