Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1977 • 514 citations

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

1982 • 254 citations

Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction.

1992 • 248 citations

Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

1989 • 246 citations

Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.

1992 • 195 citations

Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.

1986 • 189 citations

Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma

1993 • 163 citations

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.

1985 • 154 citations

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.

1988 • 136 citations

Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.

1984 • 131 citations

Enhancement of the antitumor effects of 5-fluorouracil by folinic acid

1990 • 92 citations

Synergism and Lack of Cross-resistance Between Short-term and Continuous Exposure to Fluorouracil in Human Colon Adenocarcinoma Cells

1993 • 82 citations

Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma.

1988 • 71 citations

Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.

1985 • 70 citations

Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.

1983 • 61 citations

A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.

1988 • 56 citations

Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells

1980 • 55 citations

Biochemical modulation of 5-fluorouracil with leucovorin or delayed uridine rescue

1992 • 41 citations

Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: Enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate

1991 • 39 citations

Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma.

1988 • 29 citations

Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil

1987 • 15 citations