Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: Enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1977 • 514 citations

Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma

1975 • 420 citations

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

1982 • 254 citations

Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

1989 • 246 citations

Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.

1986 • 189 citations

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.

1985 • 154 citations

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.

1988 • 136 citations

Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.

1983 • 96 citations

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa

1991 • 94 citations

Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.

1987 • 84 citations

[18] Separation and use of enterocytes

1981 • 63 citations

The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts

1982 • 62 citations

Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.

1983 • 61 citations

A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.

1988 • 56 citations

Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells

1980 • 55 citations

Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity

1987 • 55 citations

Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo.

1989 • 43 citations

Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma

1989 • 35 citations

Tissue homogenization using a micro-dismembrator for the measurement of enzyme activities

1986 • 33 citations

Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates.

1986 • 30 citations

Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma.

1988 • 29 citations

Increased thymidylate synthase (EC 2.1.1.45) activity in normal and neoplastic proliferation.

1988 • 29 citations

Inhibition of mammalian tumour thymidylate synthetase by 5-alkylated 2′-deoxyuridine 5′-phosphates

1984 • 24 citations

Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation

1989 • 22 citations

Chromosomal and enzymatic patterns provide evidence for two types of human colon cancers with abnormal nucleotide metabolism

1988 • 18 citations

Thymidylate synthetase activity and fluorouracil sensitivity of human colonic cancer and normal mucosal tissue preparations

1981 • 14 citations

Stimulation by phytohaemagglutinin of peripheral blood lymphocytes from horse, pig, sheep and man

1982 • 13 citations

In Vitro and In Vivo Inhibition of Thymidylate Synthase of Human Colon Cancer by 5-Fluorouracil

1989 • 9 citations

Simple separation of tritiated water and [3H]deoxyuridine from [5-3H]deoxyuridine 5′-monophosphate in thymidylate synthase assay

1987 • 7 citations