Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.

The Biochemistry of Folic Acid and Related Pteridines.

1970 • 1,033 citations

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

1974 • 619 citations

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1977 • 514 citations

Tight-binding inhibitors—I

1975 • 497 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Antineoplastic and Immunosuppressive Agents

1975 • 236 citations

An Isotopic Assay for Thymidylate Synthetase^*

1966 • 212 citations

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

1978 • 175 citations

Fluorinated pyrimidines. Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides

1974 • 172 citations

Determination of the Rate of Hexokinase-Glucose Dissociation by the Isotope-trapping Method

1974 • 142 citations

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

1981 • 137 citations

Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

1979 • 121 citations

Comparative studies of fluorinated pyrimidines with various cell lines.

1968 • 93 citations

Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.

1980 • 86 citations

Mouse ascites sarcoma 180 deoxythymidine kinase. General properties and inhibition studies

1974 • 62 citations

A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells

1980 • 61 citations

Thymidylate synthetase purified to homogeneity from human leukemic cells.

1979 • 59 citations

Synthesis of 5-fluorouridine 5′-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin—II. Correlation between the tumor levels of the enzyme and the 5-fluorouracil-promoted increase in survival of tumor-bearing mice

1969 • 57 citations

Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells

1980 • 55 citations

Interaction of drugs inhibiting different steps in the synthesis of DNA.

1972 • 55 citations

Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.

1982 • 48 citations

Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma

1977 • 45 citations

Isolation and characterisation of Chinese hamster cells resistant to 5-fluorodeoxyuridine

1976 • 43 citations

Studies on fluorinated pyrimidines. X. In vivo studies on tumor resistance.

1960 • 42 citations

Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma.

1975 • 41 citations

Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate complexes. Evidence for large conformational changes during catalysis

1980 • 30 citations

Properties of dihydrofolate reductase from a methotrexate-resistant subline of human KB cells and comparison with enzyme from KB parent cells and mouse S180 AT/3000 cells.

1982 • 28 citations

Isolation and characterization of 5-fluorouracil-resistant mutants of Chinese hamster ovary cells deficient in the activities of orotate phosphoribosyltransferase and orotidine 5?-monophosphate decarboxylase

1980 • 27 citations

Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography

1976 • 25 citations

Mutation induction by 5-fluorodeoxyuridine in synchronous Chinese hamster cells.

1979 • 25 citations