Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

1974 • 619 citations

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.

1991 • 375 citations

Fluorinated Pyrimidines and Their Nucleosides

1975 • 333 citations

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

1982 • 254 citations

Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

1989 • 246 citations

Antineoplastic and Immunosuppressive Agents

1975 • 236 citations

Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.

1981 • 195 citations

Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.

1992 • 195 citations

Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.

1990 • 182 citations

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.

1985 • 154 citations

Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites.

1988 • 154 citations

Stimulation of 5-fluorouracil metabolic activation by interferon-α in human colon carcinoma cells

1992 • 127 citations

Interferon effects upon fluorouracil metabolism by HL-60 cells

1989 • 121 citations

Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation.

1980 • 119 citations

5-Fluorouracil incorporation in DNA of human breast carcinoma cells.

1982 • 117 citations

5-Fluoro-2'-deoxyuridine incorporation in L1210 DNA.

1981 • 103 citations

Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.

1983 • 96 citations

Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.

1988 • 96 citations

Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.

1987 • 84 citations

Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil.

1984 • 80 citations

Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originating from neoplastic tissues

1983 • 73 citations

Combining Chemotherapy With Biological Response Modifiers in Treatment of Cancer

1988 • 71 citations

Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.

1980 • 71 citations

Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.

1991 • 67 citations

Nucleotide Formation as a Determinant of 5-Fluorouracil Response in Mouse Leukemias

1966 • 65 citations

Effects of 5-fluoro-2'-deoxyuridine on DNA metabolism in HeLa cells.

1983 • 63 citations

Cytolytic activity of interferon‐gamma and its synergism with 5‐fluorouracil

1984 • 57 citations

A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.

1988 • 56 citations

The mechanism of 5-fluorouridine toxicity in Novikoff hepatoma cells.

1976 • 49 citations

Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.

1982 • 48 citations

Combined effects of 5-fluorouracil and interferon on proliferation of human neoplastic cells in culture.

1982 • 46 citations

The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro.

1979 • 39 citations

In vitro studies on potentiation of cytotoxic effects of anticancer drugs by interferon on a human neoplastic cell line (HeLa)

1983 • 39 citations

Interaction Between 5-FluorouraciI, [6RS]Leucovorin, and Recombinant Human Interferon-α2a in Cultured Colon Adenocarcinoma Cells

1991 • 34 citations

Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA.

1990 • 29 citations

Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma

1986 • 28 citations

Enhancement of actinomycin D- and cis-diamminedichloroplatinum(II)-induced killing of human fibroblasts by human beta-interferon.

1983 • 28 citations

Recent Developments in Mass Spectrometry for the Analysis of Complex Mixtures

1983 • 25 citations

2-Deoxyglucose: Inhibition of Parasitemia and of Glucosamine Incorporation into Glycosylated Macromolecules, in Malarial Parasites (<i>Plasmodium falciparu</i><i>m</i>)

1981 • 24 citations

An artefact explains the apparent association of the transferrin receptor with a ras gene product

1984 • 22 citations

Enhanced Inhibition of Anticancer Drugs by Human Recombinant Gamma-Interferon for Human Renal Cell Carcinoma in Vitro

1987 • 21 citations

Resistance of CCRF-CEM cloned sublines to 5-fluorodeoxyuridine associated with enhanced phosphatase activities

1985 • 20 citations

Concurrent allopurinol and 5-fluorouracil: 5-fluoro-2?-deoxyuridylate formation and thymidylate synthase inhibition in rat colon carcinoma and in regenerating rat liver

1987 • 10 citations

[Antitumor effect of interferons with chemotherapeutic agents].

1986 • 8 citations