Endothelial function in the isolated perfused mesentery and aortae of rats with streptozotocin‐induced diabetes: effect of treatment with the aldose reductase inhibitor, ponalrestat

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

1990 • 1,020 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat

1965 • 630 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus

1992 • 563 citations

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

1992 • 527 citations

Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia

1992 • 475 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications.

1989 • 374 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Regeneration and Repair of Myelinated Fibers in Sural-Nerve Biopsy Specimens from Patients with Diabetic Neuropathy Treated with Sorbinil

1988 • 298 citations

Impairment of endothelium‐dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin‐induced diabetic rats

1989 • 294 citations

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

1988 • 255 citations

Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway

1992 • 216 citations

Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus.

1992 • 215 citations

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 • 193 citations

Effect of Insulin and Oral Glutathione on Glutathione Levels and Superoxide Dismutase Activities in Organs of Rats With Streptozocin-Induced Diabetes

1986 • 183 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Mechanism of impaired responses of cerebral arterioles during diabetes mellitus

1991 • 179 citations

Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus

1989 • 174 citations

Endothelium-Dependent Relaxation in Aorta of BB Rat

1987 • 151 citations

A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy

1990 • 142 citations

Endothelium‐dependent relaxation and noradrenaline sensitivity in mesenteric resistance arteries of streptozotocin‐induced diabetic rats

1992 • 140 citations

Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus.

1992 • 136 citations

Aldose Reductase Inhibition: An Approach to the Prevention of Diabetic Complications

1987 • 124 citations

A Contrasting effect of the diabetic state upon the contractile responses of aortic preparations from the rat and rabbit

1987 • 115 citations

Influence of the endothelium on contractile responses of arteries from diabetic rats

1988 • 106 citations

The influence of chronic experimental diabetes on contractile responses of rat isolated blood vessels

1985 • 100 citations

Endothelial cell function in diabetic microangiopathy

1987 • 97 citations

Aldose Reductase Inhibition Restores Endothelial Cell Function in Diabetic Rabbit Aorta

1993 • 95 citations

Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline‐induced contractility in mesenteric resistance arteries from streptozotocin‐induced diabetic rats

1994 • 92 citations

Modulation of vascular tonus by the endothelium in experimental diabetes

1987 • 88 citations

Effects of experimental diabetes on the responsiveness of rat aorta

1989 • 88 citations

Bioassay of endothelium-derived relaxing factor in diabetic rat aorta

1992 • 86 citations

Von Willebrand Factor and Development of Diabetic Nephropathy in IDDM

1991 • 86 citations

Endothelium-dependent relaxation in aorta of BB rat

1987 • 76 citations

Enhanced vascular alpha-adrenergic neuroeffector system in diabetes: importance of calcium

1988 • 68 citations

Glucose-induced microvascular functional changes in nondiabetic rats are stereospecific and are prevented by an aldose reductase inhibitor.

1990 • 63 citations

Mechanism of glucose-induced (Na+, K+)-ATPase inhibition in aortic wall of rabbits

1989 • 61 citations

Effect of ouabain on endothelium-dependent relaxation of human resistance arteries.

1991 • 59 citations

Injury of arterial endothelial cells in diabetic, sucrose-fed and aged rats

1984 • 39 citations

Adrenergic denervation in rabbits with diabetes mellitus

1990 • 38 citations

INCREASED α₂‐ADRENORECEPTOR MEDIATED VASCULAR CONTRACTION IN DIABETIC RATS

1983 • 38 citations

Dissociation between biochemical and functional effects of the aldose reductase inhibitor, ponalrestat, on peripheral nerve in diabetic rats

1992 • 37 citations

Altered microvascular reactivity to endothelin‐1, endothelin‐3 and N^G‐nitro‐L‐arginine methyl ester in streptozotocin‐induced diabetes mellitus

1992 • 36 citations

Supersensitivity and Endothelium Dependency of Histamine-induced Relaxation in Mesenteric Arteries Isolated from Diabetic Rats

1986 • 35 citations

von Willebrand factor and development of diabetic nephropathy in IDDM

1991 • 34 citations

Aldose reductase and myo-inositol in endothelial cell dysfunction caused by elevated glucose.

1992 • 33 citations

Differences in vascular responses to vasoactive agents of basilar artery and aorta from rabbits with alloxan-induced diabetes

1990 • 33 citations

Effect of diabetes on vascular smooth muscle function in normotensive and spontaneously hypertensive rat mesenteric artery

1987 • 31 citations

Endothelium-dependent relaxation to acetylcholine in the aorta of streptozotocin induced diabetic-rat and the BB-diabetic rat.

1989 • 23 citations

Histamine relaxation of aortic rings from diabetic rats

1989 • 21 citations

Altered Responsiveness of Diabetic Dog Renal Arteries to Acetylcholine and Phenylephrine: Role of Endothelium

1989 • 15 citations

Norepinephrine-induced contractile responses in isolated rat aortae from different duration of diabetes.

1992 • 13 citations

Sorbitol in aortic endothelium of diabetic rats.

1988 • 4 citations

Contractile and relaxant responses of diabetic dog femoral arteries.

1988 • 4 citations