Genetics of infectious disease resistance

Common West African HLA antigens are associated with protection from severe malaria

1991 • 1,570 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria

1994 • 1,199 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein.

1995 • 770 citations

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

1995 • 750 citations

Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy–negative individuals

1995 • 731 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

1995 • 591 citations

Molecular basis of opsonic defect in immunodeficient children

1991 • 559 citations

Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2)

1995 • 541 citations

A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein

1994 • 507 citations

Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.

1995 • 459 citations

Association between an MHC Class II Allele and Clearance of Hepatitis B Virus in the Gambia

1995 • 439 citations

Racial Differences in Susceptibility to Infection byMycobacterium tuberculosis

1990 • 407 citations

High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene

1992 • 404 citations

Mannose binding protein gene mutations associated with unusual and severe infections in adults

1995 • 357 citations

Genetic analysis of type 1 diabetes using whole genome approaches.

1995 • 256 citations

Increased frequency of homozygosity of abnormal mannan-binding-protein alleles in patients with suspected immunodeficiency

1995 • 238 citations

DUAL ROLE OF MANNAN‐BINDING PROTEIN IN INFECTIONS: ANOTHER CASE OF HETEROSIS?

1994 • 215 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

Fca Receptor Iia (Cd32) Polymorphism In Fulminant Meningococcal Septic

1994 • 200 citations

HLA-UNKED GENETIC CONTROL OF HOST RESPONSE TO MYCOBACTERIUM LEPRÆ

1976 • 188 citations

Fca Receptor Iia (Cd32) Heterogeneity In Patients With Recurrent Bacterial Respiratory Tract Infections

1994 • 181 citations

Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.

1995 • 174 citations

Hepatitis B virus markers in Chinese twins.

1989 • 163 citations

Genomic Organization and Sequence of the Human NRAMP Gene: Identification and Mapping of a Promoter Region Polymorphism

1995 • 149 citations

Enhanced virus resistance of transgenic mice expressing the human MxA protein

1995 • 130 citations

HLA and hepatitis B infection

1994 • 129 citations

Statistical evaluation of multiple-locus linkage data in experimental species and its relevance to human studies: application to nonobese diabetic (NOD) mouse and human insulin-dependent diabetes mellitus (IDDM).

1993 • 118 citations

Associations between HLA Frequencies and Pathogenic Features of Human Immunodeficiency Virus Type 1 Infection in Seroconverters from the Amsterdam Cohort of Homosexual Men

1994 • 109 citations

Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DR beta chain.

1995 • 106 citations

Malaria resistance genes: a natural selection

1992 • 98 citations

HLA Segregation of Tuberculoid Leprosy: Confirmation of the DR2 Marker

1980 • 95 citations

The level of the serum opsonin, mannan-binding protein in HIV-1 antibody-positive patients

1995 • 87 citations

Association between secretor status and respiratory viral illness.

1991 • 84 citations

HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection.

1994 • 83 citations

Study of HLA class II alleles by PCR oligotyping in leprosy patients from North India

1993 • 81 citations

Human leukocyte antigens and natural selection by malaria

1994 • 79 citations

Immunogenetics in the analysis of resistance to intracellular pathogens

1995 • 75 citations

Mannan-binding protein—levels in plasma and upper-airways secretions and frequency of genotypes in children with recurrence of otitis media

1993 • 71 citations

Human Leukocyte Antigen and Leprosy: Study in Northern Louisiana and Review

1990 • 66 citations

An RFLP map for 2q33‐q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy

1993 • 53 citations

Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21

1988 • 51 citations

Non-secretion of blood group antigens and susceptibility to infection byCandidaspecies

1989 • 50 citations

Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings

1995 • 47 citations

Concordance of human leukocyte antigen haplotype-sharing, CD4 decline and AIDS in hemophilic siblings

1995 • 42 citations

HLA and elephantiasis in lymphatic filariasis

1995 • 34 citations

Genetic control of susceptibility to leprosy in French Polynesia; no evidence for linkage with markers on telomeric human chromosome 2.

1994 • 22 citations

Blood group, secretor status, and susceptibility to infection by Neisseria gonorrhoeae.

1983 • 12 citations