Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes

Adhesion receptors of the immune system

1990 • 6,585 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Leukocyte adhesion to endothelium in inflammation

1990 • 882 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Cell Surface Receptors for Extracellular Matrix Molecules

1987 • 793 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines.

1984 • 424 citations

Adhesive protein receptors on hematopoietic cells

1988 • 350 citations

Structure of the Integrin VLA‐4 and its Cell‐Cell and Cell‐Matrix Adhesion Functions

1990 • 345 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

1990 • 316 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

1990 • 300 citations

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

1989 • 291 citations

Association of the VLA a Subunit with a Novel Protein

1989 • 285 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.

1990 • 251 citations

VLA‐3: A novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization

1986 • 214 citations

On the mode of action of LFA-1

1990 • 208 citations

Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.

1990 • 193 citations

An alternative leukocyte homotypic adhesion mechanism, LFA-1/ICAM-1-independent, triggered through the human VLA-4 integrin.

1990 • 180 citations

Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium.

1990 • 154 citations

A monoclonal antibody to VLA-4 alpha-chain (CDw49d) induces homotypic lymphocyte aggregation.

1990 • 142 citations

Human B lymphocytes define an alternative mechanism of adhesion to fibronectin. The interaction of the alpha 4 beta 1 integrin with the LHGPEILDVPST sequence of the type III connecting segment is sufficient to promote cell attachment.

1990 • 132 citations

Identification of a monoclonal antibody against platelet GPIIb that interacts with a calcium-binding site and induces aggregation.

1990 • 71 citations

Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25.

1987 • 66 citations

Lymphocyte Surface Antigen L25 Is a Member of the Integrin Receptor Superfamily

1989 • 49 citations

Primary structure of human plasma fibronectin. Characterization of a 38 kDa domain containing the C-terminal heparin-binding site (Hep III site) and a region of molecular heterogeneity

1987 • 47 citations