Leukocyte-Endothelial Cell Adhesion as an Active, Multi-Step Process: A Combinatorial Mechanism for Specificity and Diversity in Leukocyte Targeting

Adhesion receptors of the immune system

1990 • 6,585 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Rapid neutrophil adhesion to activated endothelium mediated by GMP-140

1990 • 997 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

Recognition by Elam-1 of the Sialyl-Le ^x Determinant on Myeloid and Tumor Cells

1990 • 976 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 962 citations

ELAM-1 is an adhesion molecule for skin-homing T cells

1991 • 843 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 785 citations

Biology of the rantes/sis cytokine family

1991 • 688 citations

The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140

1991 • 592 citations

The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1.

1991 • 557 citations

GPIIb-IIIa: The responsive integrin

1991 • 527 citations

A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo

1987 • 525 citations

CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x.

1991 • 505 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1

1991 • 480 citations

Lectin-like cell adhesion molecule 1 mediates leukocyte rolling in mesenteric venules in vivo

1991 • 473 citations

Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule.

1990 • 447 citations

Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro.

1991 • 439 citations

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.

1987 • 417 citations

Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1.

1989 • 413 citations

Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 • 391 citations

Activation-independent binding of human memory T cells to adhesion molecule ELAM-1

1991 • 379 citations

Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium

1990 • 370 citations

Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils.

1991 • 347 citations

Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.

1991 • 343 citations

Carbohydrate ligands of the LEC cell adhesion molecules

1990 • 338 citations

Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.

1988 • 333 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor.

1991 • 308 citations

The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor.

1991 • 307 citations

Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing.

1988 • 302 citations

Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin

1991 • 294 citations

The Regulation of Lymphocyte Traffic

1986 • 285 citations

Transient adhesion of neutrophils to endothelium.

1989 • 279 citations

Interleukin-8 induces neutrophil transendothelial migration.

1991 • 238 citations

Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.

1987 • 229 citations

Dissociation between increased surface expression of gp165/95 and homotypic neutrophil aggregation.

1988 • 156 citations

Rapid leukocyte accumulation by "spontaneous" rolling and adhesion in the exteriorized rabbit mesentery.

1991 • 121 citations

Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog

1991 • 108 citations

Dynamics of Lymphocyte-Endothelial Interactions in Vivo

1986 • 100 citations

The peripheral lymph node homing receptor, LECAM-1, is involved in CD18-independent adhesion of human neutrophils to endothelium

1991 • 93 citations

INFLAMMATION-INDUCED ENDOTHELIAL CELL ADHESION TO LYMPHOCYTES, NEUTROPHILS, AND MONOCYTES

1989 • 84 citations

Cutaneous Barriers**From the Research Laboratories of the Department of Dermatology of the Harvard Medical School at the Massachusetts General Hospital, Boston, Massachusetts 02114.

1965 • 82 citations

Cellular and Molecular Mechanisms of Inflammation

1990 • 46 citations

Vascular Addressins: Tissue Selective Endothelial Cell Adhesion Molecules for Lymphocyte Homing

1991 • 20 citations