Circulating Tumor Cells and Bone Marrow Micrometastasis

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer

2005 • 5,199 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer

2004 • 4,315 citations

ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome

2007 • 3,824 citations

Isolation of rare circulating tumour cells in cancer patients by microchip technology

2007 • 3,431 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases

2004 • 2,355 citations

Generation of a functional mammary gland from a single stem cell

2006 • 1,939 citations

Epithelial–mesenchymal transitions in development and pathologies

2003 • 1,700 citations

Models, mechanisms and clinical evidence for cancer dormancy

2007 • 1,523 citations

Epithelial-Mesenchymal Transitions

2004 • 1,470 citations

Cancer Stem Cells: An Old Idea—A Paradigm Shift

2006 • 1,367 citations

A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer

2005 • 1,333 citations

Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System

2007 • 1,285 citations

Dissecting the metastatic cascade

2004 • 1,268 citations

Circulating Tumor Cells: A Novel Prognostic Factor for Newly Diagnosed Metastatic Breast Cancer

2005 • 1,092 citations

A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells

1983 • 1,054 citations

Circulating Tumor Cells at Each Follow-up Time Point during Therapy of Metastatic Breast Cancer Patients Predict Progression-Free and Overall Survival

2006 • 1,021 citations

Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With <sup>125</sup>I-5-Iodo-2′ -deoxyuridine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1970 • 990 citations

The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells

2007 • 985 citations

Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer

2000 • 927 citations

Circulating tumor cells (CTC) detection: Clinical impact and future directions

2007 • 916 citations

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

2004 • 909 citations

Stem Cells and Cancer: Two Faces of Eve

2006 • 909 citations

Metastasis genes: A progression puzzle

2002 • 793 citations

Circulating Tumor Cells versus Imaging—Predicting Overall Survival in Metastatic Breast Cancer

2006 • 770 citations

Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype

2006 • 654 citations

From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression

2003 • 619 citations

Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression

2007 • 612 citations

Differential Expression of the Epithelial-Mesenchymal Transition Regulators Snail, SIP1, and Twist in Gastric Cancer

2002 • 573 citations

Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients

1992 • 563 citations

Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to Paclitaxel

2007 • 533 citations

Differential Expression of Proliferation-Associated Molecules in Individual Micrometastatic Carcinoma Cells

1993 • 514 citations

Detection and Clinical Importance of Micrometastatic Disease

1999 • 505 citations

HER-2 gene amplification can be acquired as breast cancer progresses

2004 • 504 citations

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer

2002 • 479 citations

Quantitation of cell shedding into efferent blood of mammary adenocarcinoma.

1975 • 444 citations

Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction.

1994 • 443 citations

Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors [see comments]

1994 • 436 citations

A Model of Human Tumor Dormancy: An Angiogenic Switch From the Nonangiogenic Phenotype

2006 • 408 citations

Metastatic Inefficiency

1990 • 407 citations

Circulating Tumor Cells in Breast Cancer: Correlation to Bone Marrow Micrometastases, Heterogeneous Response to Systemic Therapy and Low Proliferative Activity

2005 • 389 citations

Lack of Effect of Adjuvant Chemotherapy on the Elimination of Single Dormant Tumor Cells in Bone Marrow of High-Risk Breast Cancer Patients

2000 • 387 citations

Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction.

1994 • 382 citations

Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors [see comments]

1994 • 364 citations

Limitations of specific reverse-transcriptase polymerase chain reaction markers in the detection of metastases in the lymph nodes and blood of breast cancer patients.

1998 • 363 citations

Global Gene Expression Profiling of Circulating Tumor Cells

2005 • 315 citations

Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases

1996 • 314 citations

Significant Detection of Circulating Cancer Cells in the Blood by Reverse Transcriptase–Polymerase Chain Reaction During Colorectal Cancer Resection

2000 • 312 citations

Changes in Cytoskeletal Protein Composition Indicative of an Epithelial-Mesenchymal Transition in Human Micrometastatic and Primary Breast Carcinoma Cells

2005 • 300 citations

Limitations of reverse-transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow.

1997 • 290 citations

Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cells

1999 • 272 citations

Predictive and Prognostic Value of Peripheral Blood Cytokeratin-19 mRNA-Positive Cells Detected by Real-Time Polymerase Chain Reaction in Node-Negative Breast Cancer Patients

2006 • 267 citations

HER2-Positive Circulating Tumor Cells Indicate Poor Clinical Outcome in Stage I to III Breast Cancer Patients

2006 • 261 citations

Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer

1995 • 253 citations

Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer

2005 • 250 citations

Different Prognostic Value of Cytokeratin-19 mRNA–Positive Circulating Tumor Cells According to Estrogen Receptor and HER2 Status in Early-Stage Breast Cancer

2007 • 237 citations

Clinical Significance of Immunocytochemical Detection of Tumor Cells Using Digital Microscopy in Peripheral Blood and Bone Marrow of Breast Cancer Patients

2004 • 235 citations

A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation

2006 • 226 citations

Molecular signature associated with bone marrow micrometastasis in human breast cancer.

2003 • 226 citations

Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR.

1997 • 224 citations

Tumor-Cell Homing to Lymph Nodes and Bone Marrow and CXCR4 Expression in Esophageal Cancer

2005 • 217 citations

Epithelial Cells in Bone Marrow of Breast Cancer Patients at Time of Primary Surgery: Clinical Outcome During Long-Term Follow-Up

2001 • 203 citations

ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients.

2001 • 190 citations

Isolated Tumor Cells in Bone Marrow Three Years after Diagnosis in Disease-Free Breast Cancer Patients Predict Unfavorable Clinical Outcome1

2004 • 186 citations

The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence

2005 • 174 citations

The detection of micrometastases in the peripheral blood and bone marrow of patients with breast cancer using immunohistochemistry and reverse transcriptase polymerase chain reaction for keratin 19

1997 • 170 citations

Detection of Occult Bone Marrow Micrometastases in Patients with Operable Lung Carcinoma

1995 • 170 citations

Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors

2002 • 163 citations

Isolation by size of epithelial tumor cells in peripheral blood of patients with breast cancer: correlation with real-time reverse transcriptase–polymerase chain reaction results and feasibility of molecular analysis by laser microdissection

2006 • 162 citations

Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment.

2000 • 162 citations

Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro

1998 • 160 citations

Detection of circulating cytokeratin-positive cells in the blood of breast cancer patients using immunomagnetic enrichment and digital microscopy.

2002 • 155 citations

Real-time RT–PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer

2006 • 151 citations

Immunocytochemical detection of isolated epithelial cells in bone marrow: non-specific staining and contribution by plasma cells directly reactive to alkaline phosphatase

1998 • 147 citations

Response of Circulating Tumor Cells to Systemic Therapy in Patients With Metastatic Breast Cancer: Comparison of Quantitative Polymerase Chain Reaction and Immunocytochemical Techniques

2000 • 147 citations

Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer

2007 • 146 citations

Standardized quantification of circulating peripheral tumor cells from lung and breast cancer

2005 • 145 citations

Hepatocyte Growth Factor Inhibits Anoikis in Head and Neck Squamous Cell Carcinoma Cells by Activation of ERK and Akt Signaling Independent of NFκB

2002 • 136 citations

Comparison of the clinical significance of occult tumor cells in blood and bone marrow in breast cancer

2005 • 133 citations

Detection of circulating urothelial cancer cells in the blood using the CellSearch System

2007 • 132 citations

Comparison of HER2 status between primary tumor and disseminated tumor cells in␣primary breast cancer patients

2006 • 129 citations

Host genetics influence tumour metastasis

2006 • 126 citations

Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging.

2000 • 122 citations

Detection and isolation of prostate cancer cells from peripheral blood and bone marrow

2003 • 117 citations

Isolation and Molecular Profiling of Bone Marrow Micrometastases Identifies TWIST1 as a Marker of Early Tumor Relapse in Breast Cancer Patients

2007 • 111 citations

Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR

2000 • 106 citations

Genomic Profiling of Viable and Proliferative Micrometastatic Cells from Early-Stage Breast Cancer Patients

2004 • 106 citations

Tumor cell dormancy: An NCI workshop report

2007 • 102 citations

Immunocytochemical Detection of Disseminated Tumor Cells in the Bone Marrow of Patients With Esophageal Carcinoma

1996 • 99 citations

The clinical significance of circulating tumor cells

2007 • 98 citations

Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer

1999 • 97 citations

Biological implications of tumor cells in blood and bone marrow of pancreatic cancer patients

2001 • 95 citations

Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival

2005 • 94 citations

Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients

2005 • 92 citations

Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR

2006 • 86 citations

Micrometastatic bone marrow involvement: detection and prognostic significance

1999 • 83 citations

Detection of rare disseminated tumor cells identifies head and neck cancer patients at risk of treatment failure.

2003 • 83 citations

Circulating HER2 mRNA-positive cells in the peripheral blood of patients with stage I and II breast cancer after the administration of adjuvant chemotherapy: evaluation of their clinical relevance

2007 • 82 citations

Detection and analysis of cancer cells in blood and bone marrow using a rare event imaging system.

2000 • 76 citations

Tumor cell detection in peripheral blood and bone marrow

2005 • 74 citations

Minimal Residual Disease in Gastric Cancer: Evidence of an Independent Prognostic Relevance of Urokinase Receptor Expression by Disseminated Tumor Cells in the Bone Marrow

2002 • 74 citations

Asynchronous Growth of Prostate Cancer Is Reflected by Circulating Tumor Cells Delivered from Distinct, Even Small Foci, Harboring Loss of Heterozygosity of the PTEN Gene

2006 • 69 citations

Detection of cytokeratin-positive cells in the bone marrow of breast cancer patients undergoing adjuvant therapy

2005 • 68 citations

Modeling Growth Kinetics and Statistical Distribution of Oligometastases

2006 • 66 citations

Prognostic significance of circulating tumour cells enumerated after filtration enrichment in early and metastatic breast cancer patients

2006 • 66 citations

Reliable and Sensitive Identification of Occult Tumor Cells Using the Improved Rare Event Imaging System

2004 • 66 citations

Hepatocyte Growth Factor Inhibits Anoikis by Induction of Activator Protein 1-dependent Cyclooxygenase-2

2002 • 64 citations

Detection and Characterization of Residual Disease in Breast Cancer

1994 • 60 citations

Cancer Dormancy from Mice to Man: A Review

2006 • 59 citations

Primary systemic therapy does not eradicate disseminated tumor cells in breast cancer patients

2007 • 56 citations

Detection of micrometastatic cells in breast cancer by RT-PCR for the mammaglobin gene

2002 • 55 citations

Combined automatic immunological and molecular cytogenetic analysis allows exact identification and quantification of tumor cells in the bone marrow.

2001 • 50 citations

Immunocytochemical monitoring of micrometastatic disease: Reduction of prostate cancer cells in bone marrow by androgen deprivation

1997 • 50 citations

Immunocytochemical detection of isolated tumour cells in bone marrow of patients with untreated stage C prostatic cancer

1995 • 50 citations

Use of automated microscopy for the detection of disseminated tumor cells in bone marrow samples

2001 • 48 citations

Mikrometastasen im Knochenmark von Patienten mit Karzinomen des Kopf-Hals-Bereiches *^,**

1994 • 44 citations

Comparative immunocytochemical assessment of isolated carcinoma cells in lymph nodes and bone marrow of patients with clinically localized prostate cancer

1999 • 39 citations

Breast Cancer–Specific mRNA Transcripts Presence in Peripheral Blood After Adjuvant Chemotherapy Predicts Poor Survival Among High-Risk Breast Cancer Patients Treated With High-Dose Chemotherapy With Peripheral Blood Stem Cell Support

2006 • 39 citations

Observation of circulating tumour cells in patients with non-small cell lung cancer by real-time fluorescent quantitative reverse transcriptase-polymerase chain reaction in peroperative period

2005 • 37 citations

Immunomagnetic separation for enrichment and sensitive detection of disseminated tumour cells in patients with head and neck SCC

1999 • 36 citations

Detection and clinical implications of minimal residual disease in gastro-intestinal cancer

2005 • 35 citations

Quantification of circulating tumour cells for the monitoring of adjuvant therapy in breast cancer: An increase in cell number at completion of therapy is a predictor of early relapse

2007 • 35 citations

Clinical Relevance of Circulating Tumour Cells in the Bone Marrow of Patients with SCCHN

2004 • 32 citations

Detection of occult breast cancer cells by amplification of CK19 mRNA by reverse transcriptase-polymerase chain reaction: role of surgical manipulation.

2003 • 24 citations

Effects of whole body hyperthermia (41.8 degrees C) on the frequency of tumor cells in the peripheral blood of patients with advanced malignancies.

2003 • 21 citations

Immunocytochemical Phenotyping of Disseminated Tumor Cells in Bone Marrow by uPA Receptor and CK18: Investigation of Sensitivity and Specificity of an Immunogold/Alkaline Phosphatase Double Staining Protocol

1997 • 19 citations

Isolated Organ Perfusion Does Not Result in Systemic Microembolization of Tumor Cells

1999 • 12 citations