Copy Number Aberrations in Mouse Breast Tumors Reveal Loci and Genes Important in Tumorigenic Receptor Tyrosine Kinase Signaling

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Induction of Mammary Tumors by Expression of Polyomavirus Middle T Oncogene: A Transgenic Mouse Model for Metastatic Disease

1992 • 812 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

Expression of survivin and its relationship to loss of apoptosis in breast carcinomas

2000 • 561 citations

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1999 • 445 citations

High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer

2000 • 442 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

Molecular cytogenetics of primary breast cancer by CGH

1998 • 362 citations

Fully Automatic Quantification of Microarray Image Data

2002 • 349 citations

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas

2001 • 305 citations

Array Comparative Genomic Hybridization Analysis of Genomic Alterations in Breast Cancer Subtypes

2004 • 223 citations

Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis

2000 • 220 citations

Requirement for Both Shc and Phosphatidylinositol 3′ Kinase Signaling Pathways in Polyomavirus Middle T-Mediated Mammary Tumorigenesis

1998 • 200 citations

Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors

1994 • 188 citations

First-line, single-agent Herceptin® (trastuzumab) in metastatic breast cancer

2001 • 185 citations

5′ Phospholipid Phosphatase SHIP-2 Causes Protein Kinase B Inactivation and Cell Cycle Arrest in Glioblastoma Cells

2000 • 178 citations

Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival

1999 • 161 citations

Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer

2001 • 160 citations

Proteomic analysis reveals that 14-3-3sigma is down-regulated in human breast cancer cells.

2001 • 158 citations

The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines.

2003 • 146 citations

Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation

1997 • 143 citations

Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.

2003 • 116 citations

Polyoma virus middle T antigen and its role in identifying cancer-related molecules

2002 • 114 citations

neu/ERBB2 Cooperates with p53-172H during Mammary Tumorigenesis in Transgenic Mice

1997 • 107 citations

Genomic and Expression Profiling of Chromosome 17 in Breast Cancer Reveals Complex Patterns of Alterations and Novel Candidate Genes

2004 • 103 citations

Amplification of a 280-Kilobase Core Region at the ERBB2 Locus Leads to Activation of Two Hypothetical Proteins in Breast Cancer

2003 • 97 citations

Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells.

1993 • 97 citations

Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu

2002 • 94 citations

Premature Senescence Is a Primary Fail-safe Mechanism of ERBB2-Driven Tumorigenesis in Breast Carcinoma Cells

2005 • 94 citations

Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer.

1991 • 92 citations

Differences in genetic alterations between primary lobular and ductal breast cancers detected by comparative genomic hybridization

2001 • 88 citations

Chromosome I alterations in breast cancer: Allelic loss on Ip and Iq Is related to lymphogenic metastases and poor prognosis

1992 • 83 citations

Chromosome 11q13 abnormalities in human breast cancer.

1993 • 82 citations

A recurring pattern of chromosomal aberrations in mammary gland tumors of MMTV-cmyc transgenic mice

1999 • 79 citations

Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancers.

2003 • 63 citations

17q21-q25 aberrations in breast cancer: combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification

1999 • 59 citations

Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells.

1996 • 57 citations

Deletion mapping of chromosomal region 1p32-pter in primary breast cancer

1999 • 56 citations

Pathobiologic identification of two distinct breast carcinoma subsets with diverging clinical behaviors

1999 • 51 citations

Role of p53 in HER2-induced Proliferation or Apoptosis

2001 • 50 citations

Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation

2000 • 45 citations

Loss of heterozygosity analysis in primary mammary tumors and lung metastases of MMTV-MTAg and MMTV-neu transgenic mice.

1997 • 42 citations

Serine 257 Phosphorylation Regulates Association of Polyomavirus Middle T Antigen with 14-3-3 Proteins

1998 • 42 citations

Immunohistochemical analysis of survivin expression in primary breast cancers.

2004 • 36 citations

Mouse mammary tumor virus/v-Ha- ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4

1997 • 32 citations

Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas

2004 • 26 citations

Elevated frequency of loss of heterozygosity in mammary tumors arising in mouse mammary tumor virus/neu transgenic mice.

1999 • 25 citations