Neuroactive Steroid Modulators of the Stress Response

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Neuroactive steroids

1992 • 1,260 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

Variations in the Hypothalamic-Pituitary-Adrenal Response to Stress during the Estrous Cycle in the Rat

1991 • 664 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

Neurosteroids act on recombinant human GABAA receptors

1990 • 515 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1991 • 454 citations

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

1990 • 433 citations

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

1993 • 402 citations

Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*

1989 • 372 citations

Anesthetic Effect of Steroid Hormones.

1941 • 363 citations

Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats.

1993 • 344 citations

Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.

1990 • 328 citations

Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1989 • 320 citations

Anxiolytic activity of an endogenous adrenal steroid

1986 • 317 citations

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

1994 • 302 citations

Synthesis, metabolism, and pharmacological activity of 3.alpha.-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes

1990 • 295 citations

Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

1987 • 294 citations

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1991 • 293 citations

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency

1987 • 288 citations

Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.

1989 • 266 citations

Anxiolytic effect of progesterone is associated with increases in cortical alloprenanolone and GABAA receptor function

1993 • 257 citations

The interaction of alcohol and stress A review

1981 • 244 citations

Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone.

1990 • 210 citations

Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma

1990 • 204 citations

GABA-dependent modulation of the Cl− ionophore by steroids in rat brain

1987 • 188 citations

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

1989 • 184 citations

Society, culture, and drinking patterns reexamined

1991 • 178 citations

Drinking Patterns and Drinking Problems in 1984: Results from a General Population Survey

1987 • 175 citations

Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro

1988 • 166 citations

Adaptation of the Hypothalamic-Pituitary-Adrenal Axis to Chronic Ethanol Stress

1990 • 163 citations

The Neurosteroid, 3α‐Hydroxy‐5α‐pregnan‐20‐one, Protects against Bicuculline‐Induced Seizures during Ethanol Withdrawal in Rats

1995 • 161 citations

Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons

1992 • 154 citations

Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy

1989 • 153 citations

Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: structure-activity studies.

1994 • 148 citations

The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid.

1994 • 146 citations

Sleep induction by an adrenal steroid in the rat

1987 • 142 citations

Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex

1990 • 141 citations

Chloride channels and their modulation by neurotransmitters and drugs.

1988 • 134 citations

Temporal Changes in Plasma Adrenocorticotropin Concentration after Repeated Neurotropic Stress in Male and Female Rats

1979 • 132 citations

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

1987 • 113 citations

Repeated swim stress alters brain benzodiazepine receptors measured in vivo.

1989 • 111 citations

Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor

1990 • 109 citations

Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system

1975 • 106 citations

N-methyl-D-aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons

1994 • 103 citations

Sex differences in GABA/benzodiazepine receptor changes and corticosterone release after acute stress in rats

1994 • 92 citations

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function.

1994 • 89 citations

Benzodiazepine Enhancement of γ‐Aminobutyric Acid‐Mediated Chloride Ion Flux in Rat Brain Synaptoneurosomes

1988 • 86 citations

Alcohol, Science and Society Revisited

1982 • 83 citations

Rapid, stress-induced modification of the benzodiazepine receptor-coupled chloride ionophore

1986 • 83 citations

Antagonist-type interaction of glucocorticoids with the GABA receptor-coupled chloride channel

1987 • 75 citations

5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam

1992 • 75 citations

Steroid synthesis in rat brain cell cultures

1989 • 73 citations

5α-Reductase activity in isolated and cultured neuronal and glial cells of the rat

1990 • 68 citations

Regional variation in steroid anesthetic modulation of [35S]TBPS binding to gamma-aminobutyric acidA receptors in rat brain.

1992 • 60 citations

Nonneuronal Localization for Steroid Converting Enzyme: 3α‐Hydroxysteroid Oxidoreductase in Olfactory Tubercle of Rat Brain

1989 • 55 citations

Inhibitory influences of the adrenal steroid, 3?, 5?-tetrahydroxycorticosterone on aggression and defeat-induced analgesia in mice

1988 • 47 citations

Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: Further evidence for non-neural GABA systems

1989 • 47 citations

Repeated swim-stress reduces GABAA receptor α subunit mRNAs in the mouse hippocampus

1993 • 44 citations

Sex Differences in the Effects of Acute Swim Stress on Binding to GABA_A Receptors in Mouse Brain

1993 • 43 citations

Sedation or Seizures as Dose-Dependent Effects of Steroids

1965 • 35 citations

Analgesic effects of the putative FSH-suppressing gonadal steroid, 3α-hydroxy-4-pregnen-20-one: possible modes of action

1988 • 31 citations

Differential Modulation by the Stress Axis of Ethanol Withdrawal Seizure Expression in WSP and WSR Mice

1991 • 25 citations

The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively

1988 • 25 citations

Foot-shock stress enhances the increase of [35S]TBPS binding in the rat cerebral cortex and the convulsions induced by isoniazid

1991 • 19 citations

NMDA receptor-mediated excitoprotection of cultured cerebellar granule neurons fails to alter glutamate-induced expression of c-fos and c-jun mRNAs

1994 • 14 citations

Specific and nonspecific effects of ethanol vapor on plasma corticosterone in mice

1992 • 13 citations

Production of the Neurosteroid 3alpha‐Hydroxy‐5alpha‐pregnan‐20‐one in Man

1991 • 7 citations

Stress-related changes of benzodiazepine binding inhibitory activity (B.B.I.A.) in humans

1990 • 5 citations

Isolation and identification of 3α,21-dihydroxy-5α-pregnane-11,20-dione from urine

1965 • 3 citations