Production of the Neurosteroid 3alpha‐Hydroxy‐5alpha‐pregnan‐20‐one in Man

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Neural Gonadal Steroid Actions

1981 • 451 citations

CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS¹

1942 • 348 citations

Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?

1987 • 329 citations

Modulation of the GABA_A receptor by depressant barbiturates and pregnane steroids

1988 • 296 citations

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency

1987 • 288 citations

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

1988 • 271 citations

Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action

1987 • 222 citations

Glucocorticoids are modulators of GABAA receptors in brain

1985 • 188 citations

Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore

1988 • 187 citations

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

1989 • 184 citations

Neuro-steroids: 3β-hydroxy-δ5-derivatives in rat and monkey brain

1987 • 174 citations

Sleep induction by an adrenal steroid in the rat

1987 • 142 citations

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

1987 • 113 citations

Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one, and possible modes of action in mice

1987 • 112 citations

Occurrence and localization of 5α-steroid reductase, 3α- and 17β-hydroxysteroid dehydrogenases in hypothalamus and other brain tissues of the male rat

1971 • 110 citations

Sex steroid effects on extrahypothalamic CNS. II. Progesterone, alone and in combination with estrogen, modulates cerebellar responses to amino acid neurotransmitters

1987 • 108 citations

Steroid Anesthetics

1975 • 103 citations

Neuro-steroids: 3β-hydroxy-Δ5-derivatives in the rodent brain

1985 • 86 citations

Physiological aspects of steroids with anaesthetic properties.

1976 • 78 citations

Rapid effects of gonadal steroids upon hypothalamic neuronal membrane ultrastructure

1987 • 67 citations

Differential distribution of the 5-α-reductase in the central nervous system of the rat and the mouse: Are the white matter structures of the brain target tissue for testosterone action?

1987 • 55 citations

Neurosteroids: Steroidogenesis in primary cultures of rat glial cells after release of aminoglutethimide blockade

1989 • 37 citations

Sterols. IX. Isolation of epi-Pregnanol-3-one-20 from Human Pregnancy Urine

1937 • 37 citations

Multifaceted Interaction of Corticosteroids with the Intracellular Receptors and with Membrane GABA_A Receptor Complex in the Rat Brain

1989 • 32 citations

Is progesterone a pre-hormone in the CNS?

1987 • 31 citations

Distribution and ovarian control of progestin-metabolizing enzymes in various rat hypothalamic regions

1987 • 28 citations

Partial characterization of the microsomal and solubilized hypothalamic progesterone 5α-reductase

1984 • 21 citations

Progesterone Metabolism by the Hypothalamus, Pituitary, and Uterus of the Aged Rat*

1982 • 17 citations

Pregnenolone and its sulphate modulate GABAA-receptor-mediated contractile responses in the guinea-pig isolated ileum

1987 • 17 citations

Mechanism of action of a structural analog of alphaxalone on myelinated nerve fibre

1988 • 7 citations

Electrophysiological studies on the mechanism of progesterone action in the rat.

1969 • 5 citations