Rho/Rho-Kinase Pathway Contributes to C-Reactive Protein–Induced Plasminogen Activator Inhibitor-1 Expression in Endothelial Cells

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

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2002 • 7,873 citations

Clinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention

2003 • 2,434 citations

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2000 • 1,945 citations

Ca²⁺Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase

2003 • 1,913 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

1997 • 1,045 citations

A Self-Fulfilling Prophecy

2002 • 1,039 citations

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

1998 • 1,034 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

1998 • 933 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

2000 • 900 citations

Demonstration That C-Reactive Protein Decreases eNOS Expression and Bioactivity in Human Aortic Endothelial Cells

2002 • 854 citations

Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs

2001 • 839 citations

NF-κB: pivotal mediator or innocent bystander in atherogenesis?

2001 • 729 citations

C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells

2003 • 647 citations

Endothelin Antagonism and Interleukin-6 Inhibition Attenuate the Proatherogenic Effects of C-Reactive Protein

2002 • 641 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

C-Reactive Protein: Risk Marker or Mediator in Atherothrombosis?

2004 • 575 citations

Myosin phosphatase: Structure, regulation and function

2004 • 444 citations

The Transcription Factor NF-κB and the Regulation of Vascular Cell Function

2000 • 407 citations

Coming of Age of C-Reactive Protein

2003 • 391 citations

Rho/Rho-kinase mediated signaling in physiology and pathophysiology

2002 • 338 citations

Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β

1998 • 325 citations

Increased Thrombosis After Arterial Injury in Human C-Reactive Protein–Transgenic Mice

2003 • 288 citations

Ca ²⁺ -Dependent Activation of Rho and Rho Kinase in Membrane Depolarization–Induced and Receptor Stimulation–Induced Vascular Smooth Muscle Contraction

2003 • 285 citations

The Nuclear Factor κ-B Signaling Pathway Participates in Dysregulation of Vascular Smooth Muscle Cells in Vitroand in Human Atherosclerosis

1997 • 265 citations

Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase

2001 • 263 citations

Activation of Inflammation and Coagulation After Infusion of C-Reactive Protein in Humans

2005 • 226 citations

Vascular smooth muscle cell activation by C-reactive protein

2003 • 212 citations

Tissue Culture Methods

1980 • 195 citations

Rho kinase blockade prevents inflammation via nuclear factor κB inhibition: evidence in Crohn’s disease and experimental colitis

2003 • 185 citations

C-Reactive Protein Decreases Prostacyclin Release From Human Aortic Endothelial Cells

2003 • 185 citations

Rho-Associated Protein Kinase Contributes to Early Atherosclerotic Lesion Formation in Mice

2003 • 164 citations

Potent Activation of RhoA by Gαq and Gq-coupled Receptors

2002 • 160 citations

C-Reactive Protein–Induced In Vitro Endothelial Cell Activation Is an Artefact Caused by Azide and Lipopolysaccharide

2005 • 160 citations

Critical Role of Rho-Kinase and MEK/ERK Pathways for Angiotensin II–Induced Plasminogen Activator Inhibitor Type-1 Gene Expression

2001 • 143 citations

Effect of C-reactive protein on chemokine expression in human aortic endothelial cells

2004 • 114 citations

C-Reactive Protein Stimulates MMP-1 Expression in U937 Histiocytes Through FcγRII and Extracellular Signal-Regulated Kinase Pathway:

2003 • 105 citations

C-reactive protein activates the nuclear factor-κB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis

2003 • 91 citations

Involvement of Rho-Kinase Pathway for Angiotensin II-Induced Plasminogen Activator Inhibitor-1 Gene Expression and Cardiovascular Remodeling in Hypertensive Rats

2002 • 71 citations

Albumin permeability and electrical resistance as means of assessing endothelial monolayer integrity in vitro

1992 • 30 citations