What is the right dose for children?

Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children

2003 • 2,148 citations

Mechanism-Based Concepts of Size and Maturity in Pharmacokinetics

2007 • 985 citations

Survey of unlicensed and off label drug use in paediatric wards in European countries

2000 • 749 citations

Prediction of the Clearance of Eleven Drugs and Associated Variability in Neonates, Infants and Children

2006 • 487 citations

To scale or not to scale: the principles of dose extrapolation

2009 • 486 citations

A Size Standard for Pharmacokinetics

1996 • 470 citations

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

2009 • 343 citations

What is the best size descriptor to use for pharmacokinetic studies in the obese?

2004 • 333 citations

Scaling for size: some implications for paediatric anaesthesia dosing

2002 • 190 citations

Physiologically Based Pharmacokinetic (PBPK) Modeling of Caffeine and Theophylline in Neonates and Adults: Implications for Assessing Children's Risks from Environmental Agents

2004 • 160 citations

The problems in scaling adult drug doses to children

2007 • 154 citations

Interventions to Reduce Dosing Errors in Children

2007 • 147 citations

Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years

2009 • 141 citations

Optimizing Pediatric Dosing: A Developmental Pharmacologic Approach

2009 • 140 citations

Prediction of drug clearance in children from adults: a comparison of several allometric methods

2006 • 128 citations

Proposals for model‐based paediatric medicinal development within the current European Union regulatory framework

2009 • 120 citations

Arninoglycoside toxicity in infants and children

1986 • 119 citations

Maturational pharmacokinetics of single intravenous bolus of propofol

2007 • 110 citations

Calculation of drug dosage and body surface area of children

1997 • 101 citations

Practice Patterns of Pediatric Versus General Emergency Physicians for Pain Management of Fractures in Pediatric Patients

2004 • 90 citations

Modelling approaches to dose estimation in children

2005 • 87 citations

Prediction of Drug Clearance in Children: Impact of Allometric Exponents, Body Weight, and Age

2007 • 82 citations

Pharmacokinetics of tobramycin in cystic fibrosis

1982 • 75 citations

Carbamazepine and its 10,11-epoxide in children and adults with epilepsy

1977 • 73 citations

Treatment of symptomatic congenital cytomegalovirus infection with valganciclovir

2005 • 70 citations

Tailor-made drug treatment for children

2008 • 63 citations

A Model-Based Approach to Dose Selection in Early Pediatric Development

2010 • 60 citations

Biological and psychological differences in the child and adolescent transplant recipient

2005 • 58 citations

Population pharmacokinetics of levetiracetam and dosing recommendation in children with epilepsy

2009 • 54 citations

Disease Severity Is a Major Determinant for the Pharmacodynamics of Propofol in Critically Ill Patients

2007 • 54 citations

Population Pharmacokinetics of Oxycodone in Children 6 Months to 7 Years Old

2006 • 48 citations

Challenges for drug studies in children: CYP3A phenotyping as example

2008 • 37 citations

Free Concentration of Carbamazepine and Carbamazepine-10,11-Epoxide in Children and Adults

1985 • 36 citations

Antidotes for nerve agent poisoning: should we differentiate children from adults?

2007 • 34 citations

Pharmacokinetic/Pharmacodynamic Modeling of Anesthetics in Children

2006 • 28 citations

The pharmacokinetics of escitalopram in patients with hepatic impairment

2006 • 27 citations

Population pharmacokinetics of oral diclofenac for acute pain in children

2008 • 23 citations

Population Pharmacokinetics of Valsartan in Pediatrics

2009 • 16 citations

Chloramphenicol Pharmacokinetics in the Newborn

1983 • 15 citations

Factors affecting the pharmacokinetics of parenteral chloramphenicol in enteric fever

1997 • 12 citations

Relationship between Clinical and Biologic Variables and Chloramphenicol Pharmacokinetic Parameters in Pediatric Patients with Sepsis

2000 • 9 citations

Chloramphenicol Pharmacokinetics in African Children with Severe Malaria

2005 • 6 citations

Deleted Work

1955 • 0 citations