Modelling approaches to dose estimation in children

Human Body Composition: In Vivo Methods

2000 • 811 citations

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

2005 • 758 citations

Learning versus confirming in clinical drug development*

1997 • 607 citations

Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants

2002 • 311 citations

Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices

1997 • 298 citations

Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans

2003 • 223 citations

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

1992 • 214 citations

Inter‐individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

2003 • 163 citations

Physiologically Based Pharmacokinetic (PBPK) Modeling of Caffeine and Theophylline in Neonates and Adults: Implications for Assessing Children's Risks from Environmental Agents

2004 • 160 citations

Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children

2000 • 128 citations

The development of drug metabolising enzymes and their influence on the susceptibility to adverse drug reactions in children

2003 • 120 citations

Physiological Modeling of Age-Specific Changes in the Pharmacokinetics of Organic Chemicals in Children

2003 • 116 citations

Clinical trial simulation in drug development.

2000 • 96 citations

Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation

2003 • 89 citations

Statins and the risk of idiopathic venous thromboembolism

2002 • 75 citations

Contribution of midazolam and its 1-hydroxy metabolite to preoperative sedation in children: a pharmacokinetic-pharmacodynamic analysis

2002 • 68 citations

Developmental pharmacodynamics of cyclosporine

1999 • 65 citations

Design and power of a population pharmacokinetic study.

2001 • 59 citations

Pharmacokinetic-pharmacodynamic study of oral lansoprazole in children

2002 • 44 citations

Ranitidine, 75 mg, over‐the‐counter dose: pharmacokinetic and pharmacodynamic effects in children with symptoms of gastro‐oesophageal reflux

2002 • 40 citations

Target-Controlled Infusion of Rocuronium in Infants, Children, and Adults: A Comparison of the Pharmacokinetic and Pharmacodynamic Relationship

2003 • 33 citations

An indirect response model of homocysteine suppression by betaine: optimising the dosage regimen of betaine in homocystinuria

2002 • 33 citations

Pharmacokinetics and Pharmacodynamics of Bumetanide in Critically Ill Pediatric Patients

1998 • 23 citations

How many patients and blood levels are necessary for population pharmacokinetic analysis?

1996 • 21 citations

Developmental Pharmacokinetics and Pharmacodynamics of Nizatidine

2004 • 17 citations

The pharmacodynamics and pharmacokinetics of mivacurium in children

2002 • 14 citations

Off label drug use in children: A prospective questionnaire assessment of attitudes amongst scottish hospital based paediatricians

2004 • 6 citations