Prediction of the Clearance of Eleven Drugs and Associated Variability in Neonates, Infants and Children

Textbook of Medical Physiology

1966 • 10,259 citations

A formula to estimate the approximate surface area if height and weight be known

1916 • 4,502 citations

CLINICAL CALORIMETRY

1916 • 4,077 citations

A Simple Estimate of Glomerular Filtration Rate in Children Derived From Body Length and Plasma Creatinine

1976 • 2,338 citations

Information theory as an extension of the maximum likelihood principle

1973 • 2,276 citations

Clinical pharmacokinetics; concepts and applications

1989 • 2,266 citations

Body mass index reference curves for the UK, 1990.

1995 • 2,048 citations

Geometric method for measuring body surface area: A height-weight formula validated in infants, children, and adults

1978 • 1,607 citations

Some suggestions for measuring predictive performance

1981 • 1,576 citations

Basic anatomical and physiological data for use in radiological protection: reference values

2002 • 1,529 citations

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1999 • 1,154 citations

British 1990 growth reference centiles for weight, height, body mass index and head circumference fitted by maximum penalized likelihood

1998 • 1,061 citations

Survey of unlicensed and off label drug use in paediatric wards in European countries

2000 • 749 citations

Basic anatomical and physiological data for use in radiological protection : reference values

2002 • 695 citations

Expression of CYP3A in the Human Liver — Evidence that the Shift between CYP3A7 and CYP3A4 Occurs Immediately After Birth

1997 • 530 citations

Human liver carbamazepine metabolism

1994 • 428 citations

Basic anatomical and physiological data for use in radiological protection: reference values. A report of age- and gender-related differences in the anatomical and physiological characteristics of reference individuals. ICRP Publication 89.

2002 • 426 citations

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin*

1998 • 404 citations

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

1994 • 390 citations

Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial

1995 • 381 citations

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

2001 • 377 citations

Developmental Expression of the Major Human Hepatic CYP3A Enzymes

2003 • 355 citations

Clearance approaches in pharmacology.

1987 • 347 citations

Developmental Expression of Human Hepatic CYP2C9 and CYP2C19

2003 • 312 citations

Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants

2002 • 311 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Stroke Volume and Cardiac Output in Normotensive Children and Adults

1997 • 301 citations

Changes in liver volume from birth to adulthood: A meta-analysis

2005 • 296 citations

Midazolam kinetics

1981 • 286 citations

The pharmacokinetics of midazolam in paediatric patients

1989 • 278 citations

The pharmacokinetics of diclofenac sodium following intravenous and oral administration

1979 • 267 citations

Developmental Expression of CYP2E1 in the Human Liver

1996 • 264 citations

MATURATION OF RENAL FUNCTION IN CHILDHOOD: CLEARANCE STUDIES12

1949 • 259 citations

CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

2000 • 257 citations

Unlicensed and off label prescribing of drugs in general practice

2000 • 242 citations

Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs

2004 • 233 citations

Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

1999 • 228 citations

‘In silico’ simulations to assess the ‘in vivo’ consequences of ‘in vitro’ metabolic drug–drug interactions

2004 • 227 citations

Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans

2003 • 223 citations

Delayed ontogenesis of CYP1A2 in the human liver

1998 • 221 citations

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers

1992 • 214 citations

Glomerular filtration rate, effective renal bloodflow, and maximal tubular excretory capacity in infancy

1948 • 213 citations

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

2004 • 210 citations

Expression of CYP2D6 in developing human liver

1991 • 208 citations

Glomerular filtration rate in the first three weeks of life

1975 • 203 citations

Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite.

1996 • 197 citations

Protein binding predictions in infants

2002 • 188 citations

Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes*

1998 • 183 citations

Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility

1997 • 174 citations

Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies.

1996 • 171 citations

Body surface area prediction in normal-weight and obese patients

2001 • 165 citations

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

2000 • 165 citations

Inter‐individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

2003 • 163 citations

Metabolism of theophylline by cDNA‐expressed human cytochromes P‐450.

1995 • 163 citations

Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes

1998 • 162 citations

Physiologically Based Pharmacokinetic (PBPK) Modeling of Caffeine and Theophylline in Neonates and Adults: Implications for Assessing Children's Risks from Environmental Agents

2004 • 160 citations

Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.

1986 • 156 citations

Human Hepatic CYP2E1 Expression during Development

2003 • 153 citations

Maturation of caffeine elimination in infancy.

1979 • 151 citations

A COMPARISON OF HEPATIC CYTOCHROME P450 PROTEIN EXPRESSION BETWEEN INFANCY AND POSTINFANCY

1997 • 150 citations

Enterocytic CYP3A4 in a paediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis

2001 • 147 citations

LOCALIZATION AND mRNA EXPRESSION OF CYP3A AND P-GLYCOPROTEIN IN HUMAN DUODENUM AS A FUNCTION OF AGE

2005 • 145 citations

Pharmacokinetic analysis of the disposition of intravenous theophylline in young children

1976 • 145 citations

Nonspecific binding of drugs to human liver microsomes

2000 • 144 citations

Multidrug resistance gene (P-glycoprotein) expression in the human fetus.

1992 • 138 citations

Relationship of theophylline clearance to oral dosage in children with chronic asthma

1977 • 134 citations

Maturation of renal function in full-term and premature neonates.

1979 • 134 citations

In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration

2001 • 133 citations

Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants

2002 • 131 citations

Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.

1997 • 131 citations

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A*

1999 • 131 citations

Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients

2003 • 129 citations

Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children

2000 • 128 citations

Evaluation of Caffeine as an In Vivo Probe for CYP1A2 Using Measurements in Plasma, Saliva, and Urine

2000 • 128 citations

Prediction of drug clearance in children from adults: a comparison of several allometric methods

2006 • 128 citations

Expressing glomerular filtration rate in children

1991 • 123 citations

Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers

2000 • 122 citations

Comparison of activities of drug‐metabolizing enzymes in human fetal and adult livers

1973 • 119 citations

Prediction of Cytochrome P450-Mediated Hepatic Drug Clearance in Neonates, Infants and Children

2006 • 118 citations

Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam

1999 • 118 citations

Neonatal Hepatic Drug Elimination

2001 • 117 citations

Physiological Modeling of Age-Specific Changes in the Pharmacokinetics of Organic Chemicals in Children

2003 • 116 citations

The Single‐Dose Pharmacokinetics of Midazolam and Its Primary Metabolite in Pediatric Patients after Oral and Intravenous Administration

2001 • 111 citations

Pharmacokinetics of orally administered omeprazole in children

2000 • 110 citations

The effect of age on serum concentrations of albumin and alpha 1‐acid glycoprotein.

1990 • 108 citations

Human Hepatic CYP2E1 Expression during Development

2003 • 105 citations

Pharmacokinetics and metabolism of oral midazolam in preterm infants

2002 • 103 citations

Pharmacokinetics and Administration Regimens of Vancomycin in Neonates, Infants and Children

1997 • 100 citations

Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans

2003 • 100 citations

Human cytochrome P450 maximal activities in pediatric versus adult liver.

2000 • 97 citations

Effect of maturation on drug disposition in pediatric patients.

1987 • 96 citations

Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction*

1998 • 93 citations

Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.

1996 • 92 citations

Pharmacokinetics of orally administered omeprazole in children

2000 • 91 citations

Pharmacokinetics and bioavailability of omeprazole after single and repeated oral administration in healthy subjects.

1990 • 89 citations

Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation

2003 • 89 citations

Prediction ofin vivodrug clearance fromin vitrodata. II: Potential inter-ethnic differences

2006 • 86 citations

Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study

1999 • 79 citations

Electron microscopic studies of blood embryogenesis in humans

1965 • 77 citations

The Human Fetal Venous System

2002 • 77 citations

Statins and the risk of idiopathic venous thromboembolism

2002 • 75 citations

Comparison of methods of estimating creatinine clearance in children

1980 • 74 citations

Caffeine renal clearance and urine caffeine concentrations during steady state dosing. Implications for monitoring caffeine intake during sports events.

1991 • 73 citations

Physiological-Model-Based Derivation of the Adult and Child Pharmacokinetic Intraspecies Uncertainty Factors for Volatile Organic Compounds

2001 • 73 citations

Pharmacokinetic and Pharmacodynamic Data Analysis

2007 • 73 citations

Alterations in theophylline metabolism during the first year of life

1993 • 72 citations

The Pharmacokinetics of Omeprazole in Humans—A Study of Single Intravenous and Oral Doses

1990 • 71 citations

Analysis of Midazolam and Metabolites in Plasma by High-Performance Liquid Chromatography: Probe of CYP3A

1998 • 70 citations

Changes in Vancomycin Pharmacokinetics in Critically Ill Infants

1995 • 69 citations

Reference Man: Anatomical, Physiological and Metabolic Characteristics. Report of the Task Group on Reference Man ICRP Publication 23

1976 • 69 citations

Simultaneous modeling of the pharmacokinetics and pharmacodynamics of midazolam and diazepam

1995 • 67 citations

Role of biokinetics in risk assessment of drugs and chemicals in children

2004 • 63 citations

Dosage guidelines for the use of vancomycin based on its pharmacokinetics in infants

1988 • 60 citations

Comparison of Vancomycin Pharmacokinetics in Hospitalized Elderly and Young Patients Using a Bayesian Forecaster

1993 • 57 citations

Biotransformation of caffeine by cDNA-expressed human cytochromes P-450

1996 • 57 citations

Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: A pilot study

2001 • 55 citations

Pharmacokinetics of midazolam and alpha‐hydroxy‐midazolam following rectal and intravenous administration.

1988 • 55 citations

Comparison of methods of measuring renal function in preterm babies using inulin

1983 • 54 citations

Developmental Changes of Caffeine Elimination in Infancy

1988 • 50 citations

Pharmacokinetics of oral diclofenac and acetaminophen in children after surgery

2001 • 50 citations

Omeprazole Disposition in Children following Single‐Dose Administration

2003 • 49 citations

Vancomycin Pharmacokinetics and Bayesian Estimation in Pediatric Patients

2000 • 48 citations

Evaluation of Four Once‐Daily Aminoglycoside Dosing Nomograms

2002 • 44 citations

Pharmacokinetics of intravenous diclofenac sodium in children

1990 • 44 citations

Sensitive assay for midazolam and its metabolite 1′-hydroxymidazolam in human plasma by capillary high-performance liquid chromatography

1998 • 43 citations

Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies.

2000 • 43 citations

Oxidative Metabolism of Amprenavir in the Human Liver. Effect of the CYP3A Maturation

2003 • 43 citations

Pharmacokinetics of once-daily gentamicin dosing in pediatric patients

1998 • 42 citations

Hepatic Drug Clearance in Children: Studies with Indocyanine Green as a Model Substrate

1989 • 42 citations

Carbamazepine Phakmacokinetics in Obese and Lean Subjects

1995 • 41 citations

Normalization of glomerular filtration rate in children: body surface area, body weight or extracellular fluid volume?

1994 • 41 citations

Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms.

2001 • 40 citations

Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2

1999 • 37 citations

A useful method for predicting creatinine clearance in children.

1978 • 36 citations

Biliary Excretion of Antimicrobial Drugs

2002 • 35 citations

Selective inhibition of warfarin metabolism by diltiazem in humans.

1991 • 35 citations

Changes in Vancomycin Pharmacokinetics During Treatment

1996 • 34 citations

Pharmacokinetics of vancomycin in adult cystic fibrosis patients

1996 • 33 citations

Short Communication; Using Clinical Data to Determine Vancomycin Dosing Parameters

1990 • 33 citations

Nonlinear kinetics of phenytoin in children

1982 • 33 citations

The influence of rifampin treatment on caffeine clearance in healthy man

1995 • 33 citations

Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: Relation to free fatty acid concentration and other parameters

1983 • 31 citations

Carbamazepine Clearance in Paediatric Epilepsy Patients

1989 • 31 citations

Gentamicin Monitoring in Neonates

1988 • 31 citations

Dose estimation for children

2003 • 29 citations

Effect of Modafinil at Steady State on the Single‐Dose Pharmacokinetic Profile of Warfarin in Healthy Volunteers

2002 • 29 citations

The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor

2000 • 29 citations

Phenotyping of Drug Metabolism in Infants and Children: Potentials and Problems

1999 • 28 citations

Once-Daily Versus Multiple-Daily Gentamicin in Infants and Children

2001 • 28 citations

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A.

2001 • 27 citations

Single-dose ceftriaxone kinetics in the newborn

1985 • 27 citations

Integrated pharmacokinetics and pharmacodynamics of Ro 48–6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects

1997 • 26 citations

Evaluation of four length-weight formulas for estimating body surface area in newborn infants

1985 • 25 citations

Postnatal adjustment in renal function.

1981 • 23 citations

Population pharmacokinetics of enterally administered cisapride in young infants with gastro‐oesophageal reflux disease

1999 • 20 citations

The Effect of Age on Drug Metabolism

2003 • 20 citations

Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

2001 • 19 citations

Serum protein binding of diazepam, desmethyldiazepam, furosemide, indomethacin, warfarin, and phenobarbital in human fetus, mother, and newborn infant.

1983 • 19 citations

Paediatric Clinical Pharmacology

2006 • 18 citations

Clonazepam serum protein binding during development

1984 • 18 citations

Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers

1999 • 17 citations

Effect of vigabatrin on the pharmacokinetics of carbamazepine

2002 • 17 citations

Validation of Population Pharmacokinetic Parameters of Phenytoin Using the Parallel Michaelis-Menten and First-Order Elimination Model

2000 • 13 citations

Evaluation of Estimated and Measured Creatinine Clearances for Predicting the Pharmacokinetics of Vancomycin in Adult Liver Transplant Recipients

2003 • 12 citations

Pharmacokinetic profile of cisapride 20 mg after once- and twice-daily dosing

1998 • 11 citations

Factors affecting drug‐protein binding in the plasma of newborn infants.

1976 • 10 citations

In vitro protein binding of cefonicid and cefuroxime in adult and neonatal sera

1993 • 9 citations

Variability in pharmacokinetic values for gentamicin, tobramycin, and netilmicin in patients with renal insufficiency.

1989 • 7 citations

Clinical trials in children: guidance ICH E11

2021 • 2 citations

The Effects of Concomitant Administration of Theophylline and Toborinone on the Pharmacokinetics of Both Compounds in Poor and Extensive Metabolizers via CYP2D6

2002 • 1 citations