Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Genomic sequencing.

1984 • 8,343 citations

The scanning model for translation: an update.

1989 • 3,525 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant

1988 • 394 citations

Related functional domains in virus DNA polymerases.

1987 • 243 citations

A method for identifying the viral genes required for herpesvirus DNA replication.

1986 • 228 citations

Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant

1988 • 226 citations

Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis.

1985 • 222 citations

DNA sequence of the region in the genome of herpes simplex virus type 1 containing the genes for DNA polymerase and the major DNA binding protein

1985 • 213 citations

Cloning of herpes simplex virus type 1 sequences representing the whole genome

1981 • 202 citations

Temperature-sensitive mutants of herpes simplex virus type 1: Isolation, complementation and partial characterization

1973 • 200 citations

Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

1988 • 190 citations

Regulation of Protein Synthesis in Virus-Infected Animal Cells

1986 • 177 citations

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

1985 • 172 citations

A Genetic Approach to Promoter Recognition During trans Induction of Viral Gene Expression

1986 • 163 citations

Transcriptional and genetic analyses of the herpes simplex virus type 1 genome: coordinates 0.29 to 0.45

1984 • 160 citations

Properties of Herpes Simplex Virus DNA Polymerase and Characterization of Its Associated Exonuclease Activity

1979 • 157 citations

Herpes simplex virus resistance and sensitivity to phosphonoacetic acid

1977 • 156 citations

Identification of the herpes simplex virus DNA polymerase gene

1977 • 149 citations

Herpes simplex-1 DNA polymerase

1989 • 138 citations

Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2

1978 • 132 citations

DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants

1975 • 120 citations

Properties of Herpes simplex virus type 1 and type 2 DNA polymerase

1980 • 117 citations

Cloning, Sequencing, and Functional Analysis of ori_L, a Herpes Simplex Virus Type 1 Origin of DNA Synthesis

1985 • 112 citations

Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus

1984 • 102 citations

Physical and genetic analysis of the herpes simplex virus DNA polymerase locus

1980 • 101 citations

Genetic analysis of temperature-sensitive mutants of HSV-1: The combined use of complementation and physical mapping for cistron assignment

1983 • 100 citations

Vaccinia virus vectors utilizing the β-galactosidase assay for rapid selection of recombinant viruses and measurement of gene expression

1986 • 84 citations

Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors

1985 • 84 citations

Physical mapping of paar mutations of herpes simplex virus type 1 and type 2 by intertypic marker rescue

1979 • 80 citations

A single-base change within the DNA polymerase locus of herpes simplex virus type 2 can confer resistance to aphidicolin

1987 • 69 citations

Herpes simplex virus DNA polymerase as the site of phosphonoacetate sensitivity: temperature-sensitive mutants

1977 • 56 citations

Herpes simplex virus type 1 DNA synthesis requires the product of the UL8 gene: isolation and characterization of an ICP6::lacZ insertion mutation

1989 • 49 citations

Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability

1989 • 49 citations

Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation

1988 • 39 citations

Temperature-sensitive Mutants in Two Distinct Complementation Groups of Herpes Simplex Virus Type 1 Specify Thermolabile DNA Polymerase

1981 • 37 citations

Nucleotide sequence of the DNA polymerase gene of herps simplex virus type 1 strain Angelotti

1986 • 37 citations

Translational regulation of herpes simplex virus DNA polymerase

1990 • 33 citations

General aspects of virus drug resistance with special reference to herpes simplex virus

1986 • 30 citations

Structural Organization and Unusual Codon Usage in the DNA Polymerase Gene from Herpes Simplex Virus Type 1

1986 • 30 citations

Restoration of Wild-type Pathogenicity to an Attenuated DNA Polymerase Mutant of Herpes Simplex Virus Type 1

1986 • 27 citations

Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene

1989 • 23 citations

Genome locations of temperature-sensitive mutants in glycoprotein gB of herpes simplex virus type 1

1984 • 17 citations

Functional expression of a cloned herpes simplex virus type 1 DNA polymerase gene

1987 • 14 citations

Complementation between Phosphonoacetic Acid-resistant and -sensitive Variants of Herpes Simplex Viruses: Evidence for an Oligomeric Protein with Restricted Intracellular Diffusion as the Determinant of Resistance and Sensitivity

1981 • 9 citations

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