Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Caspases: the proteases of the apoptotic pathway

1998 • 1,048 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Role of Poly(ADP-ribose) Polymerase (PARP) Cleavage in Apoptosis

1999 • 836 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database

2000 • 426 citations

Colorectal Cancer and Nonsteroidal Anti-inflammatory Drugs

1997 • 355 citations

The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells

2000 • 255 citations

Expression and Regulation of Bcl-2, Bcl-xl, and Bax Correlate With p53 Status and Sensitivity to Apoptosis in Childhood Acute Lymphoblastic Leukemia

1997 • 212 citations

Chemotherapy-Induced Apoptosis

1997 • 155 citations

Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel.

2000 • 146 citations

Mutations of the bak gene in human gastric and colorectal cancers.

2000 • 124 citations

The Bcl-2 family and cell death regulation

1998 • 119 citations

CED-4—The Third Horseman of Apoptosis

1997 • 116 citations

Activation of caspases triggered by cytochrome c in vitro¹

1998 • 113 citations

The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium.

1998 • 111 citations

Inhibition of Caspase-3-mediated Poly(ADP-ribose) Polymerase (PARP) Apoptotic Cleavage by Human PARP Autoantibodies and Effect on Cells Undergoing Apoptosis

2000 • 110 citations

Immunohistochemical evaluation of bcl-2 protein expression in gastric adenocarcinomas

1995 • 100 citations

Apoptotic signal transduction: emerging pathways

1998 • 92 citations

Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines.

2000 • 92 citations

P53, MDM-2, BAX and BCL-2 and Drug Resistance in Chronic Lymphocytic Leukemia

1997 • 81 citations

Indomethacin induces apoptosis and inhibits proliferation in chronic myeloid leukemia cells

2000 • 55 citations

Caspase: executioner and undertaker of apoptosis.

1999 • 53 citations

Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc

1999 • 50 citations

Overexpression of protein kinase C-β1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells

2000 • 50 citations

Protein Kinase C-ε Is Necessary for Erythropoietin's Up-regulation of c-myc and for Factor-dependent DNA Synthesis

1996 • 48 citations

Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer

2000 • 42 citations

Microsatellite instability, Epstein–Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese

1999 • 42 citations

Induction of apoptosis in human gastric cancer by sodium butyrate.

2000 • 40 citations

Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc

1999 • 36 citations

Bax overexpression enhances cytochrome c release from mitochondria and sensitizes KATOIII gastric cancer cells to chemotherapeutic agent-induced apoptosis.

2000 • 26 citations

Pharmacological inhibition of protein kinase C activity could induce apoptosis in gastric cancer cells by differential regulation of apoptosis-related genes.

1999 • 20 citations

Nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer

1999 • 15 citations

Activation and the interaction of proapoptotic genes in modulating sensitivity to anticancer drugs in gastric cancer cells.

1999 • 15 citations