Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli

1991 • 556 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin.

1984 • 445 citations

Test for enterotoxigenic Escherichia coli using Y-1 adrenal cells in miniculture

1975 • 438 citations

Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity

1995 • 353 citations

Isolation and characterization of homogeneous heat-labile enterotoxins with high specific activity from Escherichia coli cultures

1979 • 345 citations

Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen.

1984 • 334 citations

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

1997 • 305 citations

Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

1993 • 299 citations

Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens

1988 • 283 citations

Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues

1989 • 252 citations

Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.

1995 • 222 citations

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography

1992 • 197 citations

Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin.

1994 • 192 citations

Mechanisms for Mucosal Immunogenicity and Adjuvancy of Escherichia coli Labile Enterotoxin

1996 • 173 citations

Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin

1997 • 172 citations

Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets.

1996 • 156 citations

Properties of homogeneous heat-labile enterotoxin from Escherichia coli

1980 • 151 citations

Oral administration of cholera toxin-Sendai virus conjugate potentiates gut and respiratory immunity against Sendai virus.

1988 • 133 citations

Galactose‐binding site in Escherichia coli heat‐labile enterotoxin (LT) and cholera toxin (CT)

1994 • 131 citations

Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action

1993 • 126 citations

Cholera toxin adjuvant greatly promotes antigen priming of T cells

1993 • 121 citations

The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant

1991 • 120 citations

Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin

1994 • 119 citations

Transcytosis of cholera toxin subunits across model human intestinal epithelia.

1995 • 113 citations

The Adjuvant Action of Cholera Toxin is Associated with an Increased Intestinal Permeability for Luminal Antigens

1991 • 111 citations

Delineation and comparison of ganglioside-binding epitopes for the toxins of Vibrio cholerae, Escherichia coli, and Clostridium tetani: evidence for overlapping epitopes.

1994 • 109 citations

Construction of a potential live oral bivalent vaccine for typhoid fever and cholera-Escherichia coli-related diarrheas

1984 • 108 citations

Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.

1994 • 107 citations

Cholera Toxin and its Subunits as Potential Oral Adjuvants

1989 • 101 citations

Cholera Toxin as a Mucosal Adjuvant

1996 • 91 citations

Morphologic and functional alterations of mucosal T cells by cholera toxin and its B subunit.

1995 • 88 citations

Cholera Toxin Enhances Alloantigen Presentation by Cultured Intestinal Epithelial Cells

1993 • 88 citations

Analysis of structure and function of the B subunit of cholera toxin by the use of site‐directed mutagenesis

1991 • 81 citations

Comparative effectiveness of the cholera toxin B subunit and alkaline phosphatase as carriers for oral vaccines

1993 • 79 citations

Analysis of receptor-binding site in Escherichia coli enterotoxin.

1985 • 76 citations

Alterations at the carboxyl terminus change assembly and secretion properties of the B subunit of Escherichia coli heat-labile enterotoxin

1987 • 63 citations

Sealed adult mice: new model for enterotoxin evaluation

1984 • 58 citations

Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates

1995 • 57 citations

Reduction in oral immunogenicity of cholera toxin B subunit by N-terminal peptide addition

1993 • 56 citations

Mucosal priming of T-lymphocyte responses to fed protein antigens using cholera toxin as an adjuvant.

1991 • 53 citations

Role of trypsin-like cleavage at arginine 192 in the enzymatic and cytotonic activities of Escherichia coli heat-labile enterotoxin

1994 • 51 citations

Effectiveness of cholera toxin B subunit as an adjuvant for nasal influenza vaccination despite pre-existing immunity to CTB

1989 • 49 citations

Use of Escherichia coli Heat-Labile Enterotoxin as an Oral Adjuvant

1996 • 44 citations

Role of a potential endoplasmic reticulum retention sequence (RDEL) and the Golgi complex in the cytotonic activity of Escherichia coli heat-labile enterotoxin

1995 • 42 citations

Development of mucosal protection against the heat-stable enterotoxin (ST) of Escherichia coli by oral immunization with a genetic fusion delivered by a bacterial vector

1993 • 36 citations

Cholera toxin as a mucosal adjuvant: III. Antibody responses to nontarget dietary antigens are not increased.

1990 • 20 citations

Chapter 12 Receptors for cholera toxin and Escherichia coli heat-labile enterotoxin revisited

1994 • 20 citations