The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

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High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Effects of cytochalasin and phalloidin on actin.

1987 • 1,989 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Clostridium difficile Colitis

1994 • 1,328 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Clostridium difficile: its disease and toxins

1988 • 574 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Small GTP-Binding Proteins

1992 • 526 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Effects of Clostridium difficile toxins given intragastrically to animals

1985 • 398 citations

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

1988 • 324 citations

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins.

1990 • 314 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

1990 • 277 citations

Biological activities of toxins A and B of Clostridium difficile

1982 • 259 citations

Clostridium difficile: Clinical Considerations

1990 • 213 citations

Purification and characterization of two components of botulinum C2 toxin

1980 • 210 citations

Differential effects of Clostridium difficile toxins A and B on rabbit ileum

1987 • 204 citations

Clostridium difficile toxin B acts on the GTP-binding protein Rho.

1994 • 204 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 193 citations

Nucleotide sequence ofClostridium difficiletoxin B gene

1990 • 177 citations

Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosum.

1992 • 169 citations

Botulinum ADP‐ribosyltransferase C3

1988 • 162 citations

Clostridium botulinum C3 ADP-Ribosyltransferase

1992 • 136 citations

Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.

1991 • 126 citations

Epidermal cell differentiation inhibitor ADP-ribosylates small GTP-binding proteins and induces hyperplasia of epidermis.

1992 • 120 citations

ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility

1991 • 117 citations

Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related

1987 • 112 citations

Clostridium difficile toxin A carries a C-terminal repetitive structure homologous to the carbohydrate binding region of streptococcal glycosyltransferases

1990 • 110 citations

Clostridium botulinum C3 ADP-ribosyltransferase gene. Cloning, sequencing, and expression of a functional protein in Escherichia coli.

1991 • 102 citations

An electrophoretic procedure for detecting proteins that bind actin monomers

1989 • 86 citations

Cellular internalisation of Clostridium difficile toxin A

1987 • 83 citations

Clostridium difficile toxin A and its effects on cells

1991 • 82 citations

Clostridium difficile toxin B induces reorganization of actin, vinculin, and talin in cultured cells

1988 • 73 citations

Functional Modification of a 21-Kilodalton G Protein when ADP-Ribosylated by Exoenzyme C3 of Clostridium botulinum

1988 • 66 citations

Lysosomal involvement in cellular intoxication with Clostridium difficile toxin B

1986 • 66 citations

Copurification of rho protein and the rho-GDP dissociation inhibitor from bovine neutrophil cytosol. Effect of phosphoinositides on rho ADP-ribosylation by the C3 exoenzyme of Clostridium botulinum

1992 • 61 citations

Novel potent inhibitor of receptor-activated nonselective cation currents in HL-60 cells.

1993 • 59 citations

Rapid death of infant rhesus monkeys injected with Clostridium difficile toxins A and B: Physiologic and pathologic basis

1984 • 58 citations

Biochemical studies on the effect of Clostridium difficile toxin B on actin in vivo and in vitro

1987 • 58 citations

rho gene products, botulinum C3 exoenzyme and cell adhesion

1993 • 57 citations

Purification of GTPase-activating protein specific for the rho gene products.

1991 • 51 citations

Effects of Clostridium Difficile toxins A and B on cytoskeleton organization in HEp-2 cells: A comparative morphological study

1989 • 48 citations

ADP-ribosylation of small GTP-binding proteins by Bacillus cereus

1992 • 48 citations

Partial purification and characterization of GDP dissociation stimulator (GDS) for the rho proteins from bovine brain cytosol

1990 • 46 citations

Involvement of rho p21 and Its Inhibitory GDP/GTP Exchange Protein (rho GDI) in Cell Motility

1993 • 46 citations

Purification of a Functional Receptor for Clostridium difficile Toxin A from Intestinal Brush Border Membranes of Infant Hamsters

1993 • 33 citations

Molecular Biology of the Clostridium difficile Toxins

1993 • 26 citations

A GTPase-activating protein for rhoB p20, a ras p21-like GTP-binding protein — partial purification, characterization and subcellular distribution in rat brain

1990 • 22 citations

Ten-Year Experience with Artificial Pneumoperitoneum for End-Stage, Drug-Resistant Pulmonary Tuberculosis

1993 • 18 citations

GTPases and Actin as Targets for Bacterial Toxins

1993 • 17 citations