Proteins of Iron Storage and Transport

Hard and Soft Acids and Bases

1963 • 9,301 citations

Advanced inorganic chemistry

1973 • 7,079 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes.

1983 • 1,586 citations

FERRITIN: STRUCTURE, GENE REGULATION, AND CELLULAR FUNCTION IN ANIMALS, PLANTS, AND MICROORGANISMS

1987 • 1,305 citations

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

1985 • 1,248 citations

Iron Transport and Storage Proteins

1980 • 1,183 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Aquatic surface chemistry

1988 • 1,072 citations

Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.

1985 • 1,044 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

1981 • 699 citations

LACTOFERRIN, AN IRON-BINBING PROTEIN NI NEUTROPHILIC LEUKOCYTES

1969 • 697 citations

Iron transport and storage

1987 • 688 citations

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.

1981 • 685 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Metalloenzymes: the entatic nature of their active sites.

1968 • 625 citations

Iron transport in microbes, plants and animals

1988 • 604 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

An iron-binding protein common to many external secretions

1966 • 589 citations

Molecular Mechanisms of Oxygen Activation

1975 • 588 citations

Stoichiometric and site characteristics of the binding of iron to human transferrin.

1978 • 585 citations

IDIOPATHIC HEMOCHROMATOSIS, AN IRON STORAGE DISEASE

1955 • 580 citations

Microbial Envelope Proteins Related to Iron

1982 • 567 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

Ferritin: design and formation of an iron-storage molecule

1984 • 559 citations

Ferritin and superoxide-dependent lipid peroxidation.

1985 • 532 citations

Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins

1984 • 531 citations

Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.

1981 • 497 citations

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.

1982 • 486 citations

Dioxygen-metal complexes: toward a unified view

1976 • 472 citations

On ferritin heterogeneity. Further evidence for heteropolymers.

1978 • 464 citations

Neutron diffraction reveals oxygen–histidine hydrogen bond in oxymyoglobin

1981 • 449 citations

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.

1983 • 448 citations

Sulphate sequestered in the sulphate-binding protein of Salmonella typhimurium is bound solely by hydrogen bonds

1985 • 445 citations

Mineralogical constitution of colloidal “hydrous ferric oxides”

1967 • 443 citations

Kinetics and product of ferrous iron oxygenation in aqueous systems

1980 • 441 citations

THE PLASMA-TO-CELL CYCLE OF TRANSFERRIN*

1963 • 432 citations

Ribonucleotide Reductase—a Radical Enzyme

1983 • 423 citations

FERROKINETICS IN MAN

1970 • 413 citations

Ferritin: structure, biosynthesis, and role in iron metabolism.

1978 • 390 citations

Low molecular weight intracellular iron transport compounds

1977 • 389 citations

Body iron excretion in man

1968 • 379 citations

Structure of human lactoferrin at 3.2-A resolution.

1987 • 375 citations

Synthetic models for the oxygen-binding hemoproteins

1977 • 367 citations

The specific binding of iron(III) and copper(II) to transferrin and conalbumin

1963 • 367 citations

Modulation of cell surface iron transferrin receptors by cellular density and state of activation

1979 • 366 citations

Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

1987 • 365 citations

Molecular structure of serum transferrin at 3.3-.ANG. resolution

1988 • 363 citations

Studies on glycoconjugates. LXIV. Complete structure of two carbohydrate units of human serotransferrin

1975 • 361 citations

TRANSFER OF IRON FROM SERUM IRON-BINDING PROTEIN TO HUMAN RETICULOCYTES*

1959 • 356 citations

Idiopathic Hemochromatosis

1977 • 355 citations

Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences

1985 • 353 citations

Primary structure of human transferrin receptor deduced from the mRNA sequence

1984 • 351 citations

An Iron-binding Component in Human Blood Plasma

1946 • 349 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.

1982 • 335 citations

Long-term Chelation Therapy in Thalassaemia Major: Effect on Liver Iron Concentration, Liver Histology, and Clinical Progress

1974 • 331 citations

Regulation of Synthesis and Turnover of Ferritin in Rat Liver

1966 • 329 citations

Novel mechanism for translational control in regulation of ferritin synthesis by iron.

1976 • 324 citations

Human transferrin: cDNA characterization and chromosomal localization.

1984 • 320 citations

Biosynthesis of the human transferrin receptor in cultured cells.

1981 • 316 citations

Blue-Green Algae: Their Excretion of Iron-Selective Chelators Enables Them to Dominate Other Algae

1976 • 308 citations

Isolation of an Iron-Containing Red Protein from Human Milk.

1960 • 297 citations

Siderophores in Relation to Plant Growth and Disease

1986 • 288 citations

The synergistic binding of anions and Fe3+ by transferrin. Implications for the interlocking sites hypothesis.

1975 • 285 citations

Proteins of iron metabolism

1977 • 282 citations

Comparative study of the iron-binding properties of human transferrinsI. Complete and sequential iron saturation and desaturation of the lactotransferrin

1980 • 275 citations

Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9.

1982 • 275 citations

The primary structure of human serum transferrin. The structures of seven cyanogen bromide fragments and the assembly of the complete structure.

1983 • 272 citations

Electron density map of apoferritin at 2.8-Å resolution

1978 • 264 citations

Nachweis von Eisenoxyd in gewissen Pigmenten

1867 • 263 citations

Préparation et propriétés de la lactosidérophiline (lactotransferrine) du lait de femme

1960 • 262 citations

Secretion of Testicular Transferrin by Cultured Sertoli Cells is Regulated by Hormones and Retinoids

1982 • 253 citations

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

1987 • 250 citations

Microbial Iron Metabolism

1974 • 250 citations

Covalent binding of fatty acid to the transferrin receptor in cultured human cells.

1981 • 246 citations

Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.

1985 • 239 citations

Raw Hen Egg White and the Role of Iron In Growth Inhibition of Shigella dysenteriae , Staphylococcus aureus , Escherichia coli and Saccharomyces cerevisiae

1944 • 237 citations

Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation.

1981 • 232 citations

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

1986 • 232 citations

The structural organization of haem synthesis in rat liver mitochondria

1969 • 231 citations

Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells.

1984 • 225 citations

Tissue iron stores

1980 • 225 citations

Rat transferrin gene expression: tissue-specific regulation by iron deficiency.

1986 • 222 citations

Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron.

1987 • 220 citations

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1985 • 218 citations

Acidification of endocytic vesicles by an ATP-dependent proton pump.

1983 • 217 citations

The Metal Combining Properties of Conalbumin¹

1953 • 216 citations

Isolation and characterization of the transferrin receptor from human placenta.

1979 • 215 citations

Induction of ferritin subunit synthesis by iron is regulated at both the transcriptional and translational levels.

1988 • 214 citations

Primary Structure of the Glycans from Human Lactotransferrin

1982 • 208 citations

Coated vesicles from human placenta carry ferritin, transferrin, and immunoglobulin G.

1982 • 208 citations

Investigations in Serum Copper. I. Nature of Serum Copper and its Relation to the Iron-Binding Protein in Human Serum.

1947 • 207 citations

Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester.

1984 • 206 citations

Transferrin receptor and its recycling in HeLa cells.

1982 • 206 citations

Ferric Oxyhydroxide Core of Ferritin

1967 • 202 citations

The transferrin receptor

1982 • 202 citations

Survival and desferrioxamine in thalassaemia major.

1982 • 202 citations

The Primary Structure of Hen Ovotransferrin

1982 • 199 citations

Organisation and sequence studies of the 17-piece chicken conalbumin gene

1979 • 199 citations

Identification of the intermolecular disulfide bonds of the human transferrin receptor and its lipid-attachment site.

1987 • 198 citations

The spectra of ferric haems and haemoproteins

2008 • 198 citations

Mechanism and kinetics of iron release from ferritin by dihydroflavins and dihydroflavin analogs

1978 • 194 citations

Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site

1987 • 192 citations

A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents

1979 • 192 citations

Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation

1986 • 187 citations

Regulation of HeLa cell transferrin receptors.

1982 • 182 citations

The release of iron from horse spleen ferritin by reduced flavins

1974 • 182 citations

The Complete Nucleotide Sequence of the Chicken Ovotransferrin mRNA

1982 • 181 citations

Metal‐Combining Properties of Human Lactoferrin (Red Milk Protein)

1968 • 181 citations

Frontiers in bioinorganic chemistry

1987 • 179 citations

Superoxide dependent iron release from ferritin in inflammatory diseases

1988 • 179 citations

The complete amino acid sequence of human serum transferrin.

1982 • 179 citations

Transferrin receptor in human placental brush border membranes. Studies on the binding of transferrin to placental membrane vesicles and the identification of a placental brush border glycoprotein with high affinity for transferrin.

1979 • 174 citations

Proteins of iron storage and transport

1986 • 173 citations

Transferrin receptor: Its biological significance

1985 • 172 citations

The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes

1984 • 170 citations

Reductive mobilisation of ferritin iron

1985 • 170 citations

Transferrins: insights into structure and function from studies on lactoferrin

1987 • 167 citations

Rapid endocytosis of the transferrin receptor in the absence of bound transferrin.

1985 • 167 citations

Studies on the Binding of Iron to Transferrin and Conalbumin

1966 • 166 citations

Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells.

1987 • 165 citations

Transferrin receptors and iron uptake during erythroid cell development

1982 • 164 citations

Both subunits of rat liver ferritin are regulated at a translational level by iron induction

1986 • 164 citations

Structure and composition of ferritin cores isolated from human spleen, limpet (Patella vulgata) hemolymph and bacterial (Pseudomonas aeruginosa) cells

1986 • 158 citations

Reduction of mammalian ferritin.

1985 • 158 citations

FERRITIN AND APOFERRITIN IN THE ULTRACENTRIFUGE

1944 • 157 citations

FERRITIN

1942 • 156 citations

Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia.

1987 • 156 citations

Characterization of the binding, kinetics, and redox stability of vanadium(IV) and vanadium(V) protein complexes in serum

1986 • 155 citations

Studies on glycoconjugates. LXIV. Complete structure of two carbohydrate units of human serotransferrin

1975 • 154 citations

Mössbauer spectroscopic studies of human haemosiderin and ferritin

1984 • 153 citations

CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXVII. THE METAL-COMBINING GLOBULIN OF HUMAN PLASMA 1

1949 • 153 citations

Autoradiographic Localization of 125I-Labelled Transferrin in Rabbit Reticulocytes

1969 • 153 citations

New Multidentate Ligands. VI. Chelating Tendencies of N,N′-Di(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic Acid

1967 • 153 citations

An X-ray scattering study of ferritin and apoferritin

1965 • 152 citations

The transmembrane segment of the human transferrin receptor functions as a signal peptide.

1986 • 151 citations

X-Ray Studies of Protein Interactions

1974 • 150 citations

Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells.

1987 • 147 citations

The structure of apoferritin: Molecular size, shape and symmetry from X-ray data

1963 • 146 citations

Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells.

1984 • 145 citations

Distribution of transferrin synthesis in brain and other tissues in the rat.

1987 • 144 citations

Nuclear Magnetic Relaxation Dispersion in Protein Solutions

1969 • 143 citations

The distribution of iron between the metal-binding sites of transferrin human serum

1980 • 142 citations

Difference between the two iron-binding sites of transferrin

1975 • 142 citations

FERRITIN

1943 • 141 citations

The Effect of pH upon Human Transferrin: Selective Labelling of the Two Iron‐binding Sites

1976 • 137 citations

Organization of the human transferrin gene: direct evidence that it originated by gene duplication.

1985 • 136 citations

Effect of iron chelators on the transferrin receptor in K562 cells.

1984 • 134 citations

Interactions between isolated hepatocytes and kupffer cells in iron metabolism: A possible role for ferritin as an iron carrier protein

1988 • 134 citations

NADH diferric transferrin reductase in liver plasma membrane.

1987 • 133 citations

Release of iron from ferritin by xanthine oxidase. Role of the superoxide radical

1987 • 132 citations

Structure of gene and pseudogenes of human apoferritin H

1986 • 132 citations

Transcriptional regulation by iron of the gene for the transferrin receptor.

1986 • 131 citations

Incorporation and release of inorganic phosphate in horse spleen ferritin

1978 • 128 citations

Amino acid sequence of horse spleen apoferritin

1981 • 127 citations

Ferritin: Molecular structure and iron-storage mechanisms

1981 • 126 citations

Expression of the chicken transferrin gene in transgenic mice

1983 • 126 citations

Detection of a glycosylated subunit in human serum ferritin

1981 • 125 citations

Cardiac Involvement in Cooley's Anemia

1964 • 125 citations

Iron metabolism in the erythrophagocytosing Kupffer cell

1988 • 124 citations

Reconstituted and native iron-cores of bacterioferritin and ferritin

1987 • 124 citations

Transferrin Messenger Ribonucleic Acid: Molecular Cloning and Hormonal Regulation in Rat Sertoli Cells*

1987 • 123 citations

Mössbauer spectroscopic studies of the cores of human, limpet and bacterial ferritins

1986 • 121 citations

Complete inhibition of transferrin recycling by monensin in K562 cells.

1984 • 120 citations

The interaction of transferin with isolated hepatocytes

1980 • 119 citations

Multiple mechanisms of iron-induced ferritin synthesis in HeLa cells

1985 • 119 citations

FERRITIN

1943 • 117 citations

Heme regulation of HeLa cell transferrin receptor number.

1984 • 116 citations

Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.

1983 • 115 citations

The evolution of transferrin

1982 • 114 citations

Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells.

1985 • 113 citations

Transferrin receptors and the uptake and release of iron by isolated hepatocytes

1981 • 112 citations

Iron binding by horse spleen apoferritin. A vanadyl(IV) EPR spin probe study.

1982 • 111 citations

IRON AND PROTEIN KINETICS STUDIED BY MEANS OF DOUBLY LABELED HUMAN CRYSTALLINE TRANSFERRIN*

1961 • 111 citations

Mechanism of phorbol diester-induced regulation of surface transferrin receptor involves the action of activated protein kinase C and an intact cytoskeleton.

1985 • 111 citations

Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression.

1987 • 109 citations

Transferrin gene expression. Regulation of mRNA transcription in chick liver by steroid hormones and iron deficiency.

1980 • 109 citations

A protein on Plasmodium falciparum-infected erythrocytes functions as a transferrin receptor

1986 • 109 citations

Detection and isolation of a hepatic membrane receptor for ferritin.

1983 • 109 citations

Mediterranean disease-thalassemia(Erythroblastic anemia of cooley)

1936 • 108 citations

Demonstration of two distinct transferrin receptor recycling pathways and transferrin-independent receptor internalization in K562 cells.

1986 • 106 citations

Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro.

1986 • 104 citations

Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state

1980 • 104 citations

Cloning of the gene coding for human L apoferritin

1986 • 104 citations

The Thalassaemia Syndromes.

1973 • 104 citations

Regulation of transferrin receptor expression at the cell surface by insulin-like growth factors, epidermal growth factor and platelet-derived growth factor.

1986 • 101 citations

Mössbauer spectroscopy of Escherichia coli and its iron-storage protein

1980 • 99 citations

Functional consequences of iron deficiency in human populations.

1984 • 99 citations

Siderophilin metal coordination. Difference ultraviolet spectroscopy of di-, tri-, and tetravalent metal ions with ethylenebis[(o-hydroxyphenyl)glycine]

1981 • 98 citations

Identification of the parasite transferrin receptor of Plasmodium falciparum-infected erythrocytes and its acylation via 1,2-diacyl-sn-glycerol.

1986 • 98 citations

The structures of ferritin and apoferritin: Some preliminary X-ray data

1959 • 98 citations

Transferrin and Its Receptor: Their Roles in Cell Function

1985 • 98 citations

Inhibition of reticulocyte iron uptake by NH4Cl and CH3NH2

1981 • 97 citations

Ferritin

2007 • 97 citations

Metal ion complexes of apoferritin. Evidence for initial binding in the hydrophilic channels.

1986 • 97 citations

Redox properties and Moessbauer spectroscopy of Azotobacter vinelandii bacterioferritin

1986 • 96 citations

Studies on the mechanism of iron release from transferrin

1979 • 96 citations

The transferrins

2008 • 96 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

A solid-phase radioimmunoassay for the measurement of lactoferrin in human plasma: variations with age, sex, and disease.

1976 • 95 citations

Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family.

1984 • 93 citations

The Subunit Structure of Horse Spleen Apoferritin

1971 • 91 citations

The reduction and release of iron from Fe3+ .transferrin.CO3(2-).

1979 • 91 citations

Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.

1988 • 91 citations

Transferrin gene expression. Effects of nutritional iron deficiency.

1980 • 91 citations

Investigation by 360-MHz 1H-Nuclear-Magnetic-Resonance Spectroscopy and Methylation Analysis of the Single Glycan Chain of Chicken Ovotransferrin

1979 • 90 citations

Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies.

1985 • 90 citations

Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit.

1984 • 89 citations

Complete structure of the human transferrin gene. Comparison with analogous chicken gene and human pseudogene

1987 • 88 citations

FERRITIN

1944 • 87 citations

The reticulocyte plasma membrane pathway of iron uptake as determined by the mechanism of alpha, alpha'-dipyridyl inhibition.

1983 • 87 citations

Physical characterization of the transferrin receptor in human placentae.

1981 • 86 citations

Hydrolysis of Iron(III)…Chaotic Olation Versus Nucleation

1984 • 86 citations

The structure of an iron core analog of ferritin

1968 • 86 citations

Structure and expression of the chicken ferritin H-subunit gene.

1987 • 85 citations

The importance of the 3'-untranslated region in the translational control of ferritin mRNA.

1988 • 84 citations

The isoelectric fractionation of hen's-egg ovotransferrin

1968 • 83 citations

Evidence for participation of iron in lipoxygenase reaction from optical and electron spin resonance studies.

1976 • 82 citations

Intracellular colocalization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei

1988 • 82 citations

A Mossbauer determination of the iron core particle size distribution in ferritin

1978 • 80 citations

Iron(III) clusters bound to horse spleen apoferritin: an x-ray absorption and Moessbauer spectroscopy study that shows that iron nuclei can form on the protein

1987 • 80 citations

Evidence for the bilobal nature of diferric rabbit plasma transferrin

1979 • 79 citations

Microheterogeneity in ferritin molecules

1970 • 79 citations

Ferrihydrite

1974 • 79 citations

Transferrin mRNA level in the mouse mammary gland is regulated by pregnancy and extracellular matrix.

1987 • 79 citations

New Kinetic Role for Serum Ferritin in Iron Metabolism

1974 • 79 citations

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3

1983 • 79 citations

Vanadium complexes of transferrin and ferritin in the rat

1986 • 78 citations

Subunit dimers in sheep spleen apoferritin. The effect on iron storage.

1983 • 78 citations

Subunit structure of cell surface proteins: disulfide bonding in antigen receptors, Ly-2/3 antigens, and transferrin receptors of murine T and B lymphocytes.

1981 • 78 citations

Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions.

1986 • 76 citations

Iron metabolism in reticuloendothelial cells.

1983 • 76 citations

Relaxometry of ferritin solutions and the influence of the Fe³⁺ core ions

1986 • 76 citations

Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.

1986 • 75 citations

Structure of the iron-containing core in ferritin by the extended x-ray absorption fine structure technique

1979 • 75 citations

Cellular pharmacology of deferrioxamine B and derivatives in cultured rat hepatocytes in relation to iron mobilization

1985 • 74 citations

Orally active α‐ketohydroxy pyridine iron chelators intended for clinical use: in vivo studies in rabbits

1986 • 74 citations

Rapid mobilization of ferritin iron by ascorbate in the presence of oxygen

1980 • 73 citations

Carbon dioxide and oxygen in complex formation with iron and siderophilin, the iron-binding component of human plasma.

1949 • 72 citations

Biphasic kinetics and temperature dependence of iron removal from transferrin by 3,4-LICAMS

1986 • 72 citations

Transferrin protein and iron uptake by cultured rat fibroblasts

1979 • 71 citations

Human placental coated vesicles contain receptor-bound transferrin

1981 • 71 citations

Expression of human transferrin receptor is controlled by a gene on chromosome 3: Assignment using species specificity of a monoclonal antibody

1982 • 71 citations

The Comparative Biochemistry of Avian Egg White Proteins

1960 • 70 citations

Iron-Binding Protein of Swine Serum.

1947 • 70 citations

Expression of transferrin receptors in phytohemagglutinin-stimulated human T-lymphocytes. Evidence for a three-step model.

1986 • 70 citations

Structural heterogeneity and subunit composition of horse ferritins

1982 • 70 citations

Some Factors Affecting the Release of Iron from Reticuloendothelial Cells

1971 • 69 citations

THE NATURE OF STORAGE IRON IN IDIOPATHIC HEMOCHROMATOSIS AND IN HEMOSIDEROSIS

1960 • 69 citations

Distribution of ferritin receptors and coated pits on giant HeLa cells.

1983 • 69 citations

Iron deposition in apoferritin. Evidence for the formation of a mixed valence binuclear iron complex.

1985 • 69 citations

Identification of an rRNA operon promoter from Zea mays chloroplasts which excludes the proximal tRNA^Val _GAC from the primary transcript

1985 • 68 citations

Spectroscopic studies on the binding of Iron, Terbium, and Zinc by Apoferritin

1984 • 68 citations

Multiple red cell ferritin mRNAs, which code for an abundant protein in the embryonic cell type, analyzed by cDNA sequence and by primer extension of the 5'-untranslated regions.

1986 • 68 citations

Analysis of iron-binding components in the low molecular weight fraction of rat reticulocyte cytosol

1985 • 67 citations

Regulation of transferrin receptor cycling by protein kinase C is independent of receptor phosphorylation at serine 24 in Swiss 3T3 fibroblasts.

1987 • 66 citations

Structure of horse-spleen apoferritin at 6 Å resolution

1975 • 66 citations

Structural distinction between ferritin and iron-dextran (imferon). An electron diffraction comparison.

1981 • 66 citations

An anion binding study of vanadyl(IV) human serotransferrin. Evidence for direct linkage to the metal.

1977 • 66 citations

Interaction of transferrin with iron-loaded rat peritoneal macrophages

1986 • 65 citations

Self-assembly of apoferritin from horse spleen after reversible chemical modification with 2,3-dimethylmaleic anhydride

1988 • 65 citations

A mono-sited transferrin from a representative deuterostome: the ascidian Pyura stolonifera (subphylum Urochordata)

1984 • 65 citations

Native and subunit molecular weights of apoferritin

1971 • 64 citations

Influence of altered transcription on the translational control of human ferritin expression.

1987 • 64 citations

Pulsed electron paramagnetic resonance studies of the copper complexes of transferrin.

1979 • 64 citations

A note on the composition and properties of ferritin iron cores

1987 • 64 citations

The Iron-Transport Systems of Escherichia coli

1985 • 63 citations

Size and shape determination of apotransferrin and transferrin monomers

1971 • 63 citations

Iron metabolism in BeWo chorion carcinoma cells. Transferrin-mediated uptake and release of iron.

1987 • 62 citations

Chemical modification of the arginines in transferrins

1978 • 62 citations

Low angle neutron scattering of ferritin studied by contrast variation

1976 • 62 citations

The Ultrastructure of Ferritin Macromolecules. The Lattice Structure of the Core Crystallites

1973 • 62 citations

Body Iron Loss in Animals

1978 • 62 citations

Competitive advantage of diferric transferrin in delivering iron to reticulocytes.

1983 • 61 citations

When Do Metal Complexes Protect the Biological System from Superoxide Toxicity and When Do They Enhance It?

1986 • 60 citations

The mechanisms of iron uptake by fetal rat hepatocytes in culture

1986 • 59 citations

Effect of pH and iron content of transferrin on its binding to reticulocyte receptors

1983 • 59 citations

Transferrin receptor expression during exponential and plateau phase growth of human tumour cells in culture

1984 • 59 citations

Human transferrin receptor: expression of the receptor is assigned to chromosome 3.

1982 • 59 citations

Characterization of human ferritin H chain synthetized in Escherichia coli

1987 • 59 citations

Reversible Association of Apoferritin Molecules. Comparison of Light-Scattering and Other Data^*

1967 • 58 citations

Transferrin Uptake by Cultured Rat Embryo Fibroblasts

1982 • 58 citations

Ferritin as an iron-storage protein: mechanisms of iron uptake

1986 • 58 citations

Phenolic ethylenediamine derivatives: a study of orally effective iron chelators.

1984 • 58 citations

Structural specificity of haemosiderin iron cores in iron‐overload diseases

1988 • 57 citations

On the mechanism of horse spleen apoferritin assembly: a sedimentation velocity and circular dichroism study

1987 • 57 citations

Ethoxyformylation and photooxidation of histidines in transferrins

1977 • 57 citations

Correlation of proton release and ultraviolet difference spectra associated with metal binding by transferrin

1980 • 56 citations

Fe(III).ATP complexes. Models for ferritin and other polynuclear iron complexes with phosphate.

1985 • 56 citations

Characterization and localization of an iron-binding 18-kDa glycopeptide isolated from the N-terminal half of humanlactotransferrin

1984 • 55 citations

Frontiers in Bioinorganic Chemistry

1986 • 55 citations

Factors affecting iron balance

1981 • 55 citations

THE PROTEIN CONSTITUENTS OF EGG WHITE.¹

1900 • 55 citations

Molecular cloning and sequence analysis of cDNA for human transferrin

1984 • 54 citations

Identification of the bacteria-inhibiting iron-binding protein of egg white as conalbumin.

1946 • 53 citations

Phosphorylation of the human transferrin receptor by protein kinase C is not required for endocytosis and recycling in mouse 3T3 cells.

1987 • 53 citations

Chemical Modification as a Probe of the Topography and Reactivity of Horse‐Spleen Apoferritin

1976 • 53 citations

The symbiosis of metal and protein functions

1985 • 52 citations

Synthetisches Ferritin, ein Elsen(III)-komplex des Apoferritins

1955 • 52 citations

The structure of oxy-erythrocruorin at 1.4 Å resolution

1978 • 52 citations

The biological chemistry of iron

1983 • 51 citations

Similarities between the transferrin receptor proteins on human reticulocytes and human placentae.

1981 • 51 citations

Mechanism of the self-assembly of apoferritin from horse spleen

1987 • 51 citations

Interaction of human diferric transferrin with reticulocytes.

1981 • 51 citations

Ultrastructural immunocytochemical localization of the transferrin receptor using a monoclonal antibody in human KB cells.

1985 • 51 citations

Helix packing and subunit conformation in horse spleen apoferritin

1980 • 51 citations

Stabilization of iron in a ferrous form by ferritin. A study using dispersive and conventional x-ray absorption spectroscopy.

1987 • 50 citations

The amino acid sequence of human spleen apoferritin

1982 • 49 citations

Regulation of intracellular iron distribution in K562 human erythroleukemia cells.

1986 • 49 citations

Uptake and subcellular processing of 59Fe-125I-labelled transferrin by rat liver

1986 • 49 citations

Current ideas on the chemical mechanism of ribonucleotide reductases

1985 • 47 citations

Thalassaemia in Cyprus

1973 • 47 citations

Similarity of the structure of ferritin and iron . dextran (imferon) determined by extended X-ray absorption fine structure analysis.

1979 • 46 citations

Iron metabolism and kinetics.

1966 • 46 citations

Iron uptake and utilization by mammalian cells II. Intracellular iron utilization

1984 • 46 citations

Iron nucleotides in human and rat red cells

1976 • 45 citations

Distance between metal-binding sites in transferrin: energy transfer from bound terbium(III) to iron(III) or manganese(III)

1981 • 43 citations

Cellular iron uptake from transferrin: Is endocytosis the only mechanism?

1985 • 43 citations

The chicken transferrin gene. Restriction endonuclease analysis of gene sequences in liver and oviduct DNA.

1980 • 43 citations

Structure determination of the single glycan of rabbit serotransferrin by methylation analysis and 360 MHz ¹H NMR spectroscopy

1978 • 41 citations

Mobilization of iron from reticulocyte ghosts by cytoplasmic agents

1974 • 39 citations

Characterization of the binding of ferritin to the rat liver ferritin receptor

1985 • 39 citations

Deletional analysis of the promoter region of the human transferrin receptor gene

1988 • 39 citations

The mechanism of iron uptake by the rat placenta

1985 • 38 citations

Removal of ferritin‐bound iron by <scp>DL</scp>‐dihydrolipoate and DL‐dihydrolipoamide

1986 • 38 citations

Ferritin and iron uptake by reticulocytes

1983 • 38 citations

The ultrastructure of ferritin macromolecules

1978 • 37 citations

Properties and role of ferritin in the hemolymph of the chiton Clavarizona hirtosa

1986 • 37 citations

Iron Release from Isolated Hepatocytes

1981 • 37 citations

Human placental ferritin receptor

1986 • 37 citations

Synthesis of rat transferrin in Escherichia coli containing a recombinant bacteriophage

1984 • 36 citations

The incorporation of iron by apoferritin

1957 • 36 citations

The amino acid sequence of human liver apoferritin

1983 • 35 citations

Annotation

1974 • 35 citations

Binding of Fe2+ by mammalian ferritin

1987 • 34 citations

Iron mobilization from cultured hepatocytes: Effect of desferrioxamine B

1983 • 33 citations

Structural and functional studies on ferritins

1987 • 33 citations

The effect of lysosomotrophic bases and inhibitors of transglutaminase on iron uptake by immature erythroid cells

1983 • 33 citations

Immature red cells have ferritin receptors

1981 • 33 citations

THE STRUCTURE AND COMPOSITION OF HEMOSIDERIN

1929 • 32 citations

106. Ueber das Ferratin und seine diätetische und therapeutische Anwendung

1894 • 32 citations

Transferrin binding by microvillar vesicles isolated from rat placenta

1984 • 32 citations

Oxalate and spin-labeled oxalate as probes of the anion binding site of human transferrin. Metal to anion distance.

1978 • 32 citations

The Regulation of Iron Release from the Perfused Rat Liver

1980 • 32 citations

Failure of actinomycin D to prevent induction of liver apoferritin after iron administration

1965 • 32 citations

The preparation and characterisation of some complexes of iron(II) with amino acids

1985 • 31 citations

Uptake of transferrin by rat peritoneal macrophages

1982 • 30 citations

Relevance of ferritin-binding sites on isolated mitochondria to the mobilization of iron from ferritin

1982 • 30 citations

Mössbauer spectroscopy study of iron overloaded livers

1985 • 30 citations

Nonrandom distribution of iron in circulating human transferrin

1986 • 29 citations

Subcellular localization of transferrin protein and iron in the perfused rat liver

1986 • 29 citations

Immunohistochemical localization of the iron-binding protein lactoferrin in human bronchial glands

1965 • 28 citations

The Ferritin Genes: Structure, Expression, and Regulation

1988 • 28 citations

Mitochondrial iron not bound in heme and iron-sulfur centers and its availability for heme synthesis in vitro

1985 • 27 citations

The nature of iron released by resident and stimulated mouse peritoneal macrophages

1984 • 27 citations

Some hydrodynamic properties of human transferrin

1964 • 27 citations

A kinetic study of the mechanism of ferritin formation: the effects of buffer, of pH, and of the iron content of the molecule

1979 • 27 citations

Preliminary results for the primary structure of bacterioferritin of Escherichia coli

1985 • 26 citations

Low molecular weight iron in guinea pig reticulocytes

1985 • 26 citations

A pmr study of the effects of pH and anion and metal ion binding of the histidyl residues of ovotransferrin

1981 • 26 citations

The relationship between ferritin and haemosiderin

1986 • 25 citations

Preparation and properties of a single-sited fragment from the C-terminal domain of human transferrin

1985 • 25 citations

Oxidant specificity in ferritin formation

1979 • 25 citations

Structural studies concerning human lactotransferrin: its relatedness with human serum transferrin and evidence for internal homology

1978 • 24 citations

Studies on the mechanism of ferritin formation

1978 • 23 citations

Transferrin and iron uptake by rabbit reticulocytes

1977 • 23 citations

Biochemistry of Nonheme Iron

1981 • 22 citations

Iron uptake in reticulocytes. Inhibition mediated by the ionophores monensin and nigerisin.

1985 • 22 citations

Electron-paramagnetic-resonance spectroscopy of iron-binding fragments of hen ovotransferrins

1975 • 22 citations

A new form of ferritin heterogeneity explained. Isolation and identification of a nineteen-amino-acid-residue fragment from siderosomal ferritin of rat liver

1987 • 22 citations

Studies on the mechanism of transferrin iron uptake by rat reticulocytes

1980 • 21 citations

Iron mobilization from cultured rat bone marrow macrophages

1988 • 21 citations

The relationship between lipophilicity of hydroxypyrid-4-one iron chelators and cellular iron mobilization, using an hepatocyte culture model

1986 • 21 citations

Erythrocyte Catabolism in the Inflammatory Peritoneal Monocyte

1978 • 20 citations

A study of the mechanism of ferritin formation. The effect of pH, ionic strength and temperature, inhibition by imidazole and kinetic analysis.

1980 • 20 citations

Horse spleen hemosiderin

1964 • 19 citations

Resolution of multiple endosomal compartments associated with the internalization of epidermal growth factor and transferrin

1987 • 19 citations

The identification of protected tyrosine residues in iron-ovotransferrin

1982 • 19 citations

An extended-X-ray-absorption-fine-structure study of freeze-dried and solution ovotransferrin. Evidence for water co-ordination at the metal-binding sites

1987 • 18 citations

Desferrithiocin and desferrioxamine B

1989 • 17 citations

The 5′ region of the human transferrin gene: structure and potential regulatory sites

1986 • 17 citations

Studies on heterogeneity in ferritin subunits

1983 • 17 citations

Effect of changes in the ionic environment of reticulocytes on the uptake of transferrin‐bound iron

1980 • 17 citations

Amines as inhibitors of iron transport in rabbit reticulocytes.

1986 • 17 citations

Iron mobilization from cultured rat fibroblasts and hepatocytes

1981 • 17 citations

Iron transport from sepharose-bound transferrin

1977 • 17 citations

Isolation and partial amino acid sequence of three subunit species of porcine spleen ferritin: Evidence of multiple H subunits

1987 • 16 citations

A Study of the Mechanism of Ferritin Formation

1980 • 16 citations

Low molecular weight nonheme iron and a highly labeled heme pool in the reticulocyte

1980 • 15 citations

Binding of xylenol orange to transferrin. Demonstration of metal-anion linkage

1980 • 15 citations

Iron uptake and heme synthesis by isolated rat liver mitochondria. Differic transferrin as iron donor and the effect of pyrophosphate

1985 • 14 citations

Evidence for two nonidentical subunits of bacterioferritin from Azotobacter vinelandii

1985 • 14 citations

Cytochemical Demonstration of Transferrin in the Mitochondria of Immature Human Erythroid Cells

1981 • 13 citations

Fluorescence probe measurement of the pH of the transferrin microenvironment during iron uptake by rat bone marrow erythroid cells

1986 • 13 citations

Studies on a human transferrin variant

1984 • 12 citations

Proton NMR study of effects of synergistic anion and metal ion binding on pH titration of the histidinyl side-chain residues of the half-molecules of ovotransferrin

1987 • 12 citations

DISTRIBUTION OF TRANSFERRIN AND TRANSFERRIN RECEPTORS IN THE RABBIT PLACENTA

1983 • 11 citations

Quaternary structure of apoferritin: The rotation function at 9 Å resolution

1974 • 10 citations

Iron release from transferrin: synergistic interaction between adenosine triphosphate and an ammonium sulfate fraction of hemolysate.

1986 • 10 citations

A comparative study on iron sources for mitochondrial haem synthesis including ferritin and models of transit pool species

1986 • 10 citations

The pivotal role of ferritin in cellular iron homeostasis

1988 • 9 citations

Intermediates in the reversible dissociation of apoferritin

1972 • 9 citations

Iron metabolism and oxygen toxicity

1987 • 9 citations

The Cellular Entry of EGF and Transferrin: A Problem in Intracellular Sorting

1985 • 7 citations

Crystallization and preliminary analysis of an 18,000 Mr fragment of duck ovotransferrin

1988 • 7 citations

Le mode d'action de l'AMP cyclique chez les procaryotes et les eucaryotes, CAP et protéine kinases AMPc dépendantes

1985 • 5 citations

Comparison of Amino Acid Compositions Suggest There May Be Sequence Similarities Between Bacterial Cytochromes b557.5 and Eukaryotic Ferritins

1986 • 4 citations

[Cloning of double-stranded DNA--a transcript of rat transferrin mRNA].

1984 • 4 citations

Novel tertiary structures and stereospecificities of periplasmic binding proteins involved in active transport and chemotaxis

1985 • 4 citations

The fate of intravenously administered hepatic ferritin in normal, phenylhydrazine‐treated and scorbutic guinea‐pigs

1987 • 4 citations

Over‐expression of natural and variant human H‐chain ferritins in E. coli

1988 • 4 citations

Deleted Work

1955 • 0 citations