Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

1999 • 1,570 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

1996 • 760 citations

Soluble CD14 participates in the response of cells to lipopolysaccharide.

1992 • 695 citations

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

1988 • 654 citations

Establishment of dorsal-ventral polarity in the drosophila embryo: The induction of polarity by the Toll gene product

1985 • 607 citations

Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.

1991 • 425 citations

Genetic Control of Leucocyte Responses to Endotoxin

1968 • 384 citations

Bacterial Endotoxins

1992 • 372 citations

Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway.

1992 • 273 citations

Biochemical characterization of a soluble form of the 53‐kDa monocyte surface antigen

1986 • 256 citations

The Expansion Rate and Size of the Universe

1992 • 248 citations

CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.

1995 • 186 citations

Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.

1993 • 144 citations

CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.

1994 • 120 citations

Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections.

1997 • 101 citations

Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.

1998 • 92 citations

Construction of a Lipopolysaccharide Reporter Cell Line and Its Use in Identifying Mutants Defective in Endotoxin, But Not TNF-α, Signal Transduction

1998 • 83 citations

Immunophysiology; The role of cells and cytokines in immunity and inflammation

1991 • 82 citations

Inhibition of LPS binding on human monocytes by phosphonooxyethyl analogs of lipid A

1994 • 27 citations