Rapid endocytosis of interleukin 2 receptors when clathrin-coated pit endocytosis is inhibited

Epidermal Growth Factor

1979 • 2,964 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

Endocytosis and the recycling of plasma membrane.

1983 • 1,447 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

pH and the recycling of transferrin during receptor-mediated endocytosis.

1983 • 1,165 citations

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation.

1993 • 1,125 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation.

1989 • 920 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.

1981 • 699 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-4 Receptor

1993 • 593 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1983 • 558 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Caveolae and sorting in the trans-Golgi network of epithelial cells.

1993 • 461 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts

1983 • 445 citations

Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins

1982 • 428 citations

The interleukin-2 receptor.

1991 • 354 citations

Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification.

1993 • 349 citations

Acidification of the cytosol inhibits endocytosis from coated pits.

1987 • 345 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin.

1985 • 309 citations

Living with Clathrin: Its Role in Intracellular Membrane Traffic

1988 • 304 citations

Interaction of Activated EGF Receptors with Coated Pit Adaptins

1993 • 259 citations

Ligands internalized through coated or noncoated invaginations follow a common intracellular pathway.

1987 • 254 citations

The Interleukin 2 Receptor

1989 • 244 citations

The Ways of Endocytosis

1989 • 237 citations

Effects of cytoplasmic acidification on clathrin lattice morphology.

1989 • 232 citations

Endocytosis and signals for internalization

1991 • 209 citations

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

Endocytosis: what goes in and how?

1992 • 177 citations

The mechanism of receptor‐mediated endocytosis

1991 • 164 citations

Potassium-dependent assembly of coated pits: new coated pits form as planar clathrin lattices.

1986 • 150 citations

Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptor.

1987 • 147 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Transferrin receptors promote the formation of clathrin lattices

1991 • 122 citations

Molecules internalized by clathrin-independent endocytosis are delivered to endosomes containing transferrin receptors.

1993 • 104 citations

Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region.

1991 • 103 citations

Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor.

1986 • 97 citations

Clathrin, Adapters, And Sorting

1990 • 89 citations

Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2.

1985 • 86 citations

Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

1993 • 76 citations

Selective membrane protein trafficking: vectorial flow and filter

1992 • 74 citations

Interleukin‐2 (IL‐2) receptor γ chain mutations in X‐linked severe combined immunodeficiency disease result in the loss of high‐affinity IL‐2 receptor binding

1994 • 70 citations

Receptor-mediated endocytosis of interleukin 2 in a human tumor T cell line. Degradation of interleukin 2 and evidence for the absence of recycling of interleukin receptors.

1986 • 64 citations

Down-regulation of high affinity interleukin 2 receptors in a human tumor T cell line. Interleukin 2 increases the rate of surface receptor decay.

1988 • 58 citations

Are caveolae involved in clathrin-independent endocytosis?

1993 • 56 citations

Internalization efficiency of the transferrin receptor

1992 • 55 citations

Cytokine Receptors in Congenital Hematopoietic Disease

1994 • 28 citations

Binding and internalization of biotinylated interleukin-2 in human lymphocytes

1990 • 16 citations

Murine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein.

1993 • 16 citations

Trafficking of interleukin 2 and transferrin in endosomal fractions of T lymphocytes

1994 • 16 citations

Both the alpha and beta chains of high-affinity interleukin 2 receptors are located in intracellular vesicles when their ligand is endocytosed.

1993 • 8 citations

Intracellular pathway of interleukin‐2 receptors studied using immunogold electron microscopy

1988 • 3 citations