Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

“Spontaneous” differentiation of skeletal myoblasts is dependent upon autocrine secretion of insulin-like growth factor-II

1991 • 365 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

1987 • 204 citations

Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture

1991 • 204 citations

Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

1990 • 199 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells.

1985 • 187 citations

Development regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells.

1992 • 166 citations

Differential expression of the GLUT1 and GLUT4 glucose transporters during differentiation of L6 muscle cells

1991 • 148 citations

Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

1985 • 124 citations

Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts

1986 • 120 citations

The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains.

1992 • 100 citations

Localization of transferrin receptors and insulin-like growth factor II receptors in vesicles from 3T3-L1 adipocytes that contain intracellular glucose transporters.

1989 • 96 citations

The Development of Insulin Receptors and Responsiveness Is an Early Marker of Differentiation in the Muscle Cell Line L6*

1986 • 81 citations

Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.

1991 • 77 citations

Functional activity of the two promoters of the myosin alkali light chain gene in primary muscle cell cultures: comparison with other muscle gene promoters and other culture systems

1988 • 74 citations

Multiple binding sites for myogenic regulatory factors are required for expression of the acetylcholine receptor gamma-subunit gene.

1991 • 67 citations

Changes in tyrosine phosphorylation of insulin receptors and a 170,000 molecular weight nonreceptor protein in vivo in skeletal muscle of streptozotocin-induced diabetic rats: effects of insulin and glucose.

1992 • 65 citations

Isolation and characterization of the 160,000-Da phosphotyrosyl protein, a putative participant in insulin signaling

1991 • 59 citations

Insulin and insulin-like growth factor 1 stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein in 3T3-L1 adipocytes

1988 • 48 citations

Phosphorylation of insulin-like growth factor I receptor by the insulin receptor tyrosine kinase in intact cultured skeletal muscle cells

1988 • 36 citations

Comparison of insulin and insulin-like growth factor I receptors from rat skeletal muscle and L-6 myocytes

1987 • 32 citations

Effect of GTP gamma S on insulin binding and tyrosine phosphorylation in liver membranes and L6 muscle cells

1990 • 28 citations

Differentiation-Dependent Phosphorylation of a 175,000 Molecular Weight Protein in Response to Insulin and Insulin-Like Growth Factor-I in L6 Skeletal Muscle Cells*

1989 • 21 citations

The Insulin Receptor Tyrosine Kinase

1990 • 19 citations

Insulin binding to differentiating muscle cells in culture

1983 • 18 citations

Interaction between heterologous receptor tyrosine kinases

1991 • 16 citations

Insulin-like Growth Factor I Receptors

1990 • 6 citations