AIDS-RELATED KAPOSI'S SARCOMA

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Scatter factor/hepatocyte growth factor is essential for liver development

1995 • 1,398 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1990 • 899 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

1986 • 806 citations

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

1993 • 805 citations

Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

1993 • 777 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.

1993 • 707 citations

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

1994 • 571 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6.

1990 • 500 citations

AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects

1989 • 476 citations

Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes

1990 • 438 citations

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

1990 • 437 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation

1993 • 362 citations

The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.

1993 • 355 citations

Structural biochemistry and activation of matrix metalloproteases

1993 • 347 citations

Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275

1992 • 344 citations

Nucleosides. V. The Monomesylates of 1-(2'-Deoxy-β-D-lyxofuranosyl)thymine^1,2

1964 • 337 citations

Suramin: A potent inhibitor of the reverse transcriptase of RNA tumor viruses

1979 • 286 citations

Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma

1995 • 275 citations

Extracellular matrix‐resident basic fibroblast growth factor: Implication for the control of angiogenesis

1991 • 268 citations

ANTI-RETROVIRAL EFFECTS OF INTERFERON-α IN AIDS-ASSOCIATED KAPOSI'S SARCOMA

1988 • 261 citations

Vascular permeability factor gene expression in normal and neoplastic human ovaries.

1994 • 259 citations

Oncostatin M as a Potent Mitogen for AIDS-Kaposi's Sarcoma-Derived Cells

1992 • 251 citations

Sjogren-Larsson syndrome

2005 • 245 citations

Suramin: a novel growth factor antagonist with activity in hormone-refractory metastatic prostate cancer.

1992 • 237 citations

Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone

1995 • 230 citations

Identification of a Major Growth Factor for AIDS-Kaposi's Sarcoma Cells as Oncostatin M

1992 • 227 citations

Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines

1994 • 222 citations

Angiogenic properties of human immunodeficiency virus type 1 Tat protein.

1995 • 220 citations

Clinical manifestations of classical, endemic African, and epidemic AIDS-associated Kaposi's sarcoma

1990 • 219 citations

Interferon-α with Zidovudine: Safety, Tolerance, and Clinical and Virologic Effects in Patients with Kaposi Sarcoma Associated with the Acquired Immunodeficiency Syndrome (AIDS)

1990 • 216 citations

The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion

1994 • 215 citations

SEPTICÆMIA DUE TO PORCINE STREPTOCOCCI

1975 • 212 citations

Dual-target Inhibition of HIV-1 in Vitro by Means of an Adeno-Associated Virus Antisense Vector

1992 • 206 citations

AIDS-Related Malignancies: the Emerging Epidemic

1993 • 204 citations

Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression. Implications for AIDS-Kaposi's sarcoma pathogenesis.

1992 • 203 citations

Induction of interleukin-6 during human immunodeficiency virus infection

1990 • 191 citations

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

1988 • 171 citations

Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells.

1995 • 171 citations

Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin‐binding domain and synthetic peptides from the type I repeats of thrombospondin

1993 • 155 citations

Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes

1992 • 155 citations

Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma.

1990 • 146 citations

Increasing incidence of cancers associated with the human immunodeficiency virus epidemic

1991 • 145 citations

Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS.

1994 • 136 citations

Exogenous tat protein activates human endothelial cells [see comments]

1993 • 132 citations

Vascular targeting—a new approach to the therapy of solid tumors

1994 • 130 citations

Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells

1992 • 128 citations

Inhibition by Pentosan Polysulfate (PPS) of Heparin-Binding Growth Factors Released From Tumor Cells and Blockage by PPS of Tumor Growth in Animals

1992 • 127 citations

Interleukin 6 (IL‐6) and its receptor: Their role in plasma cell neoplasias

1991 • 122 citations

Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene.

1990 • 119 citations

Administration of an anti-interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma: effect on lymphoma growth and on B clinical symptoms

1994 • 118 citations

Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors.

1991 • 118 citations

In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

1992 • 116 citations

Inhibition of angiogenesis.

1992 • 116 citations

Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type 1 in human peripheral blood mononuclear cells and in cultured T cells [see comments]

1991 • 110 citations

Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells

1994 • 106 citations

Isolation and Characterization of an Immortal Neoplastic Cell Line (KS Y-1) From AIDS-Associated Kaposi's Sarcoma

1995 • 104 citations

Role of scatter factor in the pathogenesis of AIDS-related Kaposi sarcoma.

1994 • 97 citations

Thrombin-induced release of active basic fibroblast growth factor- heparan sulfate complexes from subendothelial extracellular matrix

1993 • 95 citations

Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells

1993 • 91 citations

Inhibition of Development of Kaposi's Sarcoma-Related Lesions by a Bacterial Cell Wall Complex

1992 • 88 citations

Macrophage-active colony-stimulating factors enhance human immunodeficiency virus type 1 infection in bone marrow stem cells [see comments]

1991 • 87 citations

Oncostatin M is a mitogen for rabbit vascular smooth muscle cells.

1993 • 83 citations

Pharmacokinetics of all-trans-retinoic acid administered on an intermittent schedule.

1995 • 81 citations

Inhibitory effect of all-trans retinoic acid on the growth of freshly isolated myeloma cells via interference with interleukin-6 signal transduction [see comments]

1994 • 80 citations

Properties and Functions of Scatter Factor/Hepatocyte Growth Factor and Its Receptor c-Met

1993 • 80 citations

Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages

1992 • 79 citations

Interferon and Other Biologic Agents for the Treatment of Kaposi's Sarcoma

1991 • 79 citations

Interferon-alpha, zidovudine, and granulocyte-macrophage colony-stimulating factor: a phase I AIDS Clinical Trials Group study in patients with Kaposi's sarcoma associated with AIDS.

1992 • 78 citations

Anti-retroviral therapy of human immunodeficiency virus infection: current strategies and challenges for the future [published erratum appears in Blood 1991 Dec 15;78(12):3330]

1991 • 75 citations

Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma.

1991 • 75 citations

Thrombin-induced release of active basic fibroblast growth factor- heparan sulfate complexes from subendothelial extracellular matrix

1993 • 72 citations

Interferon-alpha induces circulating tumor necrosis factor receptor p55 in humans

1995 • 71 citations

Oncostatin M induces tyrosine phosphorylation in endothelial cells and activation of p62yes tyrosine kinase.

1992 • 66 citations

Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression.

1991 • 65 citations

Administration of Pentosan Polysulfate to Patients With Human Immunodeficiency Virus-Associated Kaposi's Sarcoma

1993 • 64 citations

Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.

1993 • 64 citations

Antiproliferative effect of retinoid compounds on Kaposi's sarcoma cells.

1994 • 61 citations

The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.

1993 • 61 citations

Development and validation of a pharmacokinetically based fixed dosing scheme for suramin.

1995 • 56 citations

Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression

1991 • 54 citations

Soluble tumor necrosis factor receptor: inhibition of human immunodeficiency virus activation.

1993 • 54 citations

Peptide growth factors stimulate macrophage colony-stimulating factor in murine stromal cells

1991 • 53 citations

Molecular Foundations of Oncology

1992 • 52 citations

Phase I/II study of intermittent all-trans-retinoic acid, alone and in combination with interferon alfa-2a, in patients with epidemic Kaposi's sarcoma.

1995 • 49 citations

Macrophage colony-stimulating factor enhances the susceptibility of macrophages to infection by human immunodeficiency virus and reduces the activity of compounds that inhibit virus binding

1994 • 46 citations

Cooperative inhibition of NF-kappa B and Tat-induced superactivation of human immunodeficiency virus type 1 long terminal repeat.

1993 • 46 citations

New directions in molecular medicine.

1994 • 43 citations

Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma

1992 • 42 citations

Antitumor effects of GBS toxin: a polysaccharide exotoxin from group B?-hemolytic streptococcus

1993 • 41 citations

Endothelial cells express the interleukin-1 receptor type I

1991 • 40 citations

Pentoxifylline for the Treatment of Infection with Human Immunodeficiency Virus

1994 • 37 citations

A Randomized Trial of the Activity and Safety of Ro 24-7429 (Tat Antagonist) versus Nucleoside for Human Immunodeficiency Virus Infection

1995 • 36 citations

An autoregulated dual-function antitat gene for human immunodeficiency virus type 1 gene therapy

1995 • 36 citations

Endothelial cells express the interleukin-1 receptor type I

1991 • 34 citations

Sodium Pentosan Polysulfate (PPS), an Anti-HIV Agent Also Exhibits Synergism with AZT, Lymphoproliferative Activity, and Virus Enhancement

1990 • 34 citations

Cytokinetic studies on the aortic endothelium and limb bud vascularization in avian embryos

1992 • 29 citations

Correlation of oncostatin M secretion by human retrovirus-infected cells with potent growth stimulation of cultured spindle cells from AIDS-Kaposi's sarcoma.

1993 • 29 citations

Antiretroviral therapy in combination with interferon for AIDS-related Kaposi's sarcoma

1991 • 27 citations

Noncytotoxic approaches to the treatment of HIV-associated Kaposi's sarcoma.

1993 • 13 citations

The Pathogenesis of AIDS Lymphomas: A Foundation for Addressing the Challeng of Therapy and Prevention

1992 • 11 citations

A PHASE I TRIAL ADMINISTERING THE ANGIOGENESIS INHIBITOR TNP-470(AGM-1470) TO PATIENTS (PTS) WITH HIV-ASSOCIATED KAPOSI'S SARCOMA(KS)

1997 • 10 citations