Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin.

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

1978 • 1,668 citations

Vesicles of variable sizes produced by a rapid extrusion procedure

1986 • 1,654 citations

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

1991 • 1,591 citations

Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

1991 • 1,370 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.

1996 • 764 citations

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

1991 • 551 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1997 • 502 citations

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1998 • 496 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

Mechanisms of apoptosis avoidance in cancer

1999 • 371 citations

Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient

1986 • 363 citations

Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice.

1989 • 351 citations

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

1995 • 323 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

BCL-X expression in multiple myeloma: possible indicator of chemoresistance.

1998 • 229 citations

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

1993 • 218 citations

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases.

1997 • 207 citations

Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model.

1994 • 187 citations

Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines

1998 • 145 citations

Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model.

1999 • 136 citations

bcl-2 and apoptosis in lymph node positive breast carcinoma

1998 • 126 citations

Apoptosis: An Overview of the Process and Its Relevance in Disease

1997 • 121 citations

Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide.

2000 • 107 citations

Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice.

1997 • 105 citations

MDA435/LCC6 and MDA435/LCC6MDR1: ascites models of human breast cancer

1996 • 102 citations

Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages

1987 • 87 citations

Liposomal doxorubicin circumvents PSC 833-free drug interactions, resulting in effective therapy of multidrug-resistant solid tumors.

1997 • 79 citations

Ribonucleases H of retroviral and cellular origin

1990 • 72 citations

Identification and Characterization of Second-Generation Antisense Oligonucleotides

1997 • 67 citations

Clinical pharmacology and antitumor efficacy of DOXIL (pegylated liposomal doxorubicin)

1998 • 49 citations

Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance.

1998 • 40 citations