bcl-2 and apoptosis in lymph node positive breast carcinoma

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Prediction of Relapse or Survival in Patients with Node-Negative Breast Cancer by DNA Flow Cytometry

1989 • 571 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

1994 • 461 citations

Bcl-2 protein expression and long-term survival in breast cancer.

1994 • 404 citations

Special Article: Chronic Lymphocytic Leukemia—an Accumulative Disease of Immunologically Incompetent Lymphocytes

1967 • 347 citations

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer

1994 • 326 citations

DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens

1988 • 301 citations

Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.

1994 • 280 citations

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer.

1995 • 203 citations

Apoptosis in breast cancer as related to histopathological characteristics and prognosis

1994 • 196 citations

Apoptosis in Toremifene-Induced Growth Inhibition of Human Breast Cancer Cells In Vivo and In Vitro

1993 • 192 citations

Censoring distributions as a measure of follow‐up in survival analysis

1986 • 160 citations

p53 and bcl-2 expression correlates with clinical outcome in a series of node-positive breast cancer patients.

1996 • 157 citations

bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer: a Southwest Oncology Group study.

1997 • 145 citations

bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells [published erratum appears in J Cell Biol 1995 Nov;131(4):following 1121]

1995 • 106 citations

Bcl‐2 expression is associated with lymph node metastasis in human ductal breast carcinoma

1995 • 99 citations

bcl-2 protein in invasive ductal breast carcinomas

1995 • 63 citations

Bcl-2 protein expression in breast cancer in relation to established prognostic factors and other clinicopathological variables

1995 • 52 citations

Expression of BCL-2 in primary breast cancer and its correlation with tumour phenotype

1994 • 50 citations

Expression of bcl-2 gene confers multidrug resistance to chemotherapy- induced cell death

1994 • 16 citations

Immunohistochemistry on Histological Sections from Small (50 mg) Samples of Pulverized Breast Cancer

1993 • 16 citations