Clinical pharmacology and antitumor efficacy of DOXIL (pegylated liposomal doxorubicin)

Risk Factors for Doxorubicin-lnduced Congestive Heart Failure

1979 • 2,308 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

1991 • 1,591 citations

Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

1991 • 1,370 citations

Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes.

1994 • 1,355 citations

Taxol: A Unique Antineoplastic Agent with Significant Activity in Advanced Ovarian Epithelial Neoplasms

1989 • 1,111 citations

Detection of Herpesvirus-Like DNA Sequences in Kaposi's Sarcoma in Patients with and Those without HIV Infection

1995 • 1,093 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Reduction of Doxorubicin Cardiotoxicity by Prolonged Continuous Intravenous Infusion

1982 • 768 citations

Anthracycline-Induced Cardiotoxicity

1996 • 754 citations

Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation.

1997 • 648 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

A Health Status Questionnaire Using 30 Items From The Medical Outcomes Study

1991 • 551 citations

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

1988 • 532 citations

The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs

1975 • 516 citations

Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies.

1995 • 476 citations

Kaposi's sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria. AIDS Clinical Trials Group Oncology Committee.

1989 • 459 citations

Adriamycin chemotherapy—efficacy, safety, and pharmacologic basis of an intermittent single high-dosage schedule

1974 • 393 citations

Clinical Pharmacokinetics of Doxorubicin

1988 • 388 citations

Phase II trial of paclitaxel in patients with progressive ovarian carcinoma after platinum-based chemotherapy: a Gynecologic Oncology Group study.

1994 • 379 citations

Doxorubicin Encapsulated in Liposomes Containing Surface‐Bound Polyethylene Glycol: Pharmacokinetics, Tumor Localization, and Safety in Patients with AIDS‐Related Kaposi's Sarcoma

1996 • 370 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of AIDS-related Kaposi's sarcoma. International Pegylated Liposomal Doxorubicin Study Group.

1998 • 354 citations

Passive tumor targeting of soluble macromolecules and drug conjugates.

1992 • 315 citations

Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice.

1992 • 303 citations

Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: results of a multicenter phase II trial.

1997 • 299 citations

Plasma pharmacokinetics of adriamycin and adriamycinol: implications for the design of in vitro experiments and treatment protocols.

1983 • 288 citations

Paclitaxel for platinum-refractory ovarian cancer: results from the first 1,000 patients registered to National Cancer Institute Treatment Referral Center 9103.

1993 • 275 citations

Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma.

1992 • 275 citations

Phase II study and long-term follow-up of patients treated with taxol for advanced ovarian adenocarcinoma.

1992 • 264 citations

The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi’s sarcoma patients treated with pegylated liposomal doxorubicin

1998 • 239 citations

Techniques for right and left ventricular endomyocardial biopsy

1978 • 235 citations

Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: pharmacokinetic studies in rodents and dogs.

1993 • 232 citations

Doxorubicin encapsulated in sterically stabilized liposomes for the treatment of a brain tumor model: biodistribution and therapeutic efficacy

1995 • 229 citations

Reduced Cardiotoxicity of Doxorubicin Delivered on a Weekly Schedule

1983 • 220 citations

Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function.

1977 • 211 citations

Cardiac ultrastructural changes induced by daunorubicin therapy

1973 • 206 citations

Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma

1989 • 199 citations

Systemic treatment of AIDS-related Kaposi's sarcoma: Results of a randomized trial

1991 • 198 citations

Propagation of a Human Herpesvirus from AIDS-Associated Kaposi's Sarcoma

1997 • 185 citations

Characterization, toxicity and therapeutic efficacy of adrïamycin encapsulated in liposomes

1982 • 176 citations

Efficacy of pegylated-liposomal doxorubicin in the treatment of AIDS-related Kaposi's sarcoma after failure of standard chemotherapy.

1997 • 170 citations

Inhibition of DNA and RNA metabolism by daunorubicin and adriamycin in L1210 mouse leukemia.

1972 • 166 citations

Changing disease patterns in patients with AIDS in a referral centre in the United Kingdom: the changing face of AIDS.

1991 • 166 citations

Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.

1995 • 165 citations

A phase I clinical trial and pharmacokinetic evaluation of liposome-encapsulated doxorubicin.

1990 • 163 citations

Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts

1994 • 160 citations

Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes

1992 • 153 citations

Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen. A prospective randomized evaluation

1990 • 151 citations

Pharmacokinetics, Biodistribution and Therapeutic Efficacy of Doxorubicin Encapsulated in Stealth® Liposomes (Doxil®)

1994 • 148 citations

An assessment of ³¹P MRS as a method of measuring pH in rat tumours

1992 • 146 citations

Pharmacokinetic and imaging studies in patients receiving a formulation of liposome-associated adriamycin

1991 • 139 citations

Initial clinical (phase I) trial of TLC D-99 (doxorubicin encapsulated in liposomes).

1993 • 137 citations

The Spectrum of Acquired Immunodeficiency Syndrome (AIDS)-associated Malignancies in San Francisco, 1980–1987

1993 • 137 citations

The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation

1980 • 134 citations

Extravasation and transcytosis of liposomes in Kaposi's sarcoma-like dermal lesions of transgenic mice bearing the HIV tat gene.

1993 • 127 citations

Antitumor Activity of Liposome-Encapsulated Doxorubicin in Advanced Breast Cancer: Phase II Study

1990 • 124 citations

Systemic administration of doxorubicin-containing liposomes in cancer patients: a phase I study

1989 • 123 citations

Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes.

1993 • 104 citations

Human Breast Carcinoma: Fibrin Deposits ans Desmoplasia. Inflammatory Cell Type and Distribution. Microvasculature and Infarction<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 104 citations

Tumour uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma

1997 • 104 citations

Efficacy and safety of Stealth liposomal doxorubicin in AIDS-related Kaposi's sarcoma

1996 • 103 citations

Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes

1993 • 98 citations

Population pharmacokinetics and pharmacodynamics of pegylated-liposomal doxorubicin in patients with AIDS-related Kaposi's sarcoma

1997 • 91 citations

Successful imaging of human cancer with indium-111-labeled phospholipid vesicles

1988 • 89 citations

Doxorubicin: Effect of different schedules on toxicity and anti-tumor efficacy

1989 • 88 citations

Cellular and plasma adriamycin concentrations in long-term infusion therapy of leukemia patients

1987 • 82 citations

Separation of liposome-associated doxorubicin from non-liposome-associated doxorubicin in human plasma: Implications for pharmacokinetic studies

1989 • 76 citations

A phase I/II study of intraperitoneally administered doxorubicin entrapped in cardiolipin liposomes in patients with ovarian cancer

1989 • 74 citations

Macrophage infiltrate and prognosis in c-erbB-2-overexpressing breast carcinomas.

1996 • 73 citations

Constant infusion schedule for adriamycin: a phase I-II clinical trial of a 30-day schedule by ambulatory pump delivery system.

1983 • 72 citations

DNA complexing antibiotics: daunomycin, adriamycin and their derivatives.

1975 • 69 citations

Clinical evaluation of long-term, continuous-infusion doxorubicin.

1983 • 54 citations

Weekly doxorubicin in the treatment of patients with AIDS-related Kaposi's sarcoma. AIDS Clinical Trials Group.

1993 • 54 citations

Plasma and cellular Adriamycin concentrations in patients with myeloma treated with ninety-six-hour continuous infusion

1987 • 53 citations

Salvage Chemotherapy for Epithelial Ovarian Carcinoma

1994 • 52 citations

Phase I and pharmacokinetic trial of liposome-encapsulated doxorubicin

1993 • 49 citations

Liposomal doxorubicin for treatment of AIDS-related Kaposi's sarcoma

1993 • 48 citations

Kaposi's sarcoma in acquired immune deficiency syndrome (AIDS).

1986 • 42 citations

Chromatographic Analysis and Pharmacokinetics of Liposome-Encapsulated Doxorubicin in Non-Small-Cell Lung Cancer Patients

1993 • 38 citations

Existence of Lipoprotein Lipase in Human Sarcomas and Carcinomas

1994 • 26 citations

Liposomal doxorubicin in AIDS-related Kaposi's sarcoma: long-term experiences

1994 • 25 citations

A phase I clinical evaluation of liposome-entrapped doxorubicin (Lip-Dox) in patients with primary and metastatic hepatic malignancy

1992 • 24 citations

Endomyocardial Changes in Anthracycline-Treated Patients with and without Irradiation

2015 • 23 citations

Preclinical and Clinical Experience with a Doxorubicin-Liposome Preparation

1990 • 22 citations

Clinical Studies with Liposomal Doxorubicin

1990 • 17 citations

Reduction in doxorubicin toxicity following liposomal delivery

1987 • 15 citations

Ultrasound as a tool to evaluate remission of cutaneous Kaposiʼs sarcoma

1993 • 11 citations

Cardiovascular Procedures/Diagnostic Techniques and Therapeutic Procedures

1987 • 7 citations

[Selective hepatic arterial infusion of liposomes containing antitumor agents].

1985 • 6 citations

[Endoscopic injection of liposomal adriamycin targeting lymph node metastasis of gastric cancer].

1991 • 6 citations